Protein Tyrosine Phosphatase SHP2 Controls Interleukin-8 Expression in Breast Cancer Cells [0.03%]
蛋白酪氨酸磷酸酶SHP2调控乳腺癌细胞中的IL-8表达
Romain J Amante,Priska Auf der Maur,Veronica Richina et al.
Romain J Amante et al.
Treatment of metastasis remains a clinical challenge and the majority of breast cancer-related deaths are the result of drug-resistant metastases. The protein tyrosine phosphatase SHP2 encoded by the proto-oncogene PTPN11 promotes breast ca...
In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts [0.03%]
利用细胞系和患者来源的异种移植在体内模拟人类乳腺癌
Eric P Souto,Lacey E Dobrolecki,Hugo Villanueva et al.
Eric P Souto et al.
Historically, human breast cancer has been modeled largely in vitro using long-established cell lines primarily in two-dimensional culture, but also in three-dimensional cultures of varying cellular and molecular complexities. A subset of c...
Sodium Acetate and Sodium Butyrate Differentially Upregulate Antimicrobial Component Production in Mammary Glands of Lactating Goats [0.03%]
乙酸钠和丁酸钠差异性诱导泌乳山羊乳腺抗菌成分合成
Yusaku Tsugami,Naoki Suzuki,Takahiro Nii et al.
Yusaku Tsugami et al.
Short-chain fatty acids activate antimicrobial component production in the intestine. However, their effects on mammary glands remain unclear. We investigated the effects of acetate and butyrate on antimicrobial component production in mamm...
Adverse Effects of High Temperature On Mammary Alveolar Development In Vitro [0.03%]
高温对乳泡发育的不利影响（体外）
Haruka Wakasa,Yusaku Tsugami,Taku Koyama et al.
Haruka Wakasa et al.
In the mammary glands during pregnancy, the alveolar buds are first branched from the mammary ducts after which they form the alveolar luminal structure for milk production postparturition. Body temperature could increase for several reason...
Ductal Carcinoma in Situ: Molecular Changes Accompanying Disease Progression [0.03%]
导管原位癌的分子改变及其伴随疾病的进展
Gemma M Wilson,Phuong Dinh,Nirmala Pathmanathan et al.
Gemma M Wilson et al.
Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive ductal carcinoma (IDC), whereby if left untreated, approximately 12% of patients develop invasive disease. The current standard of care is surgical removal of the lesio...
CCND1 Amplification in Breast Cancer -associations With Proliferation, Histopathological Grade, Molecular Subtype and Prognosis [0.03%]
乳腺癌中CCND1拷贝数增加与增殖、组织病理学分级、分子亚型和预后之间的关系
Marit Valla,Elise Klæstad,Borgny Ytterhus et al.
Marit Valla et al.
CCND1 is located on 11q13. Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype. In this study of CCND1 in primary BCs and corresponding axillary l...
Circ_0008500 Knockdown Improves Radiosensitivity and Inhibits Tumorigenesis in Breast Cancer Through the miR-758-3p/PFN2 Axis [0.03%]
circ_0008500通过miR-758-3p/PFN2轴提高乳腺癌放射敏感性并抑制肿瘤发生
Deyou Kong,Dongxing Shen,Zhikun Liu et al.
Deyou Kong et al.
Breast cancer is one of the most common malignancies worldwide. Circular RNAs (CircRNAs) were revealed to be implicated in the development of breast cancer. In this research, we aimed to investigate the role and underlying mechanism of circ...
Chronic Leptin Treatment Induces Epithelial-Mesenchymal Transition in MCF10A Mammary Epithelial Cells [0.03%]
慢性瘦素处理诱导MCF10A乳腺上皮细胞上皮间质转化
Juan Carlos Juárez-Cruz,Michal Okoniewski,Mónica Ramírez et al.
Juan Carlos Juárez-Cruz et al.
Leptin is a cytokine-like hormone that functions as a link between obesity and breast cancer (BC). Leptin treatment induces Epithelial to Mesenchymal Transition (EMT) in BC cell lines. In non-tumoral breast epithelial MCF10A cells, acute le...
Correction to: Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492 [0.03%]
乳腺上皮干细胞系D492中过表达peroxidasin增强其基础表型并抑制支化形态发生（ correction ）
Anna Karen Sigurdardottir,Arna Steinunn Jonasdottir,Arni Asbjarnarson et al.
Anna Karen Sigurdardottir et al.
Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer [0.03%]
从非编码RNA角度解码胰岛素样生长因子信号通路：迈向乳腺癌精准肿瘤学的一步
Yousra Ahmed ZeinElAbdeen,Amna AbdAlSeed,Rana A Youness
Yousra Ahmed ZeinElAbdeen
Breast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the exact molecular pathogenesis of such multifaceted disease. This high...