The Protective Effects of Small-Molecule Compound 0242 Against LPS-Induced Neuroinflammation and in P301S Tau Transgenic Mice [0.03%]
小分子化合物0242对抗LPS诱导的神经炎症及P301STau转基因小鼠模型中的保护作用研究
Xinyuan Suo,Peifeng Wan,Jie Yu et al.
Xinyuan Suo et al.
Neuroinflammation and tau pathology are central drivers of Alzheimer's disease (AD) progression, necessitating multi-target therapeutic strategies. Here, we evaluated the efficacy and mechanisms of 0242, a novel small-molecule derivative op...
Vorinostat Rescues Cognitive Deficits in a Neuroinflammatory Mouse Model: A Study of Sex Differences and the Underlying TLR4/NF-κB Mechanism [0.03%]
伏诺茋逆转小胶质细胞激活诱导的认知缺陷：性别差异及TLR4/NF-κB介导的机制研究
Hao Wu,Juntao Xia,Zhidan Shi et al.
Hao Wu et al.
With the acceleration of global aging, Alzheimer's disease (AD) poses a significant public health challenge, and effective treatments are still lacking. Neuroinflammation, particularly microglia-mediated inflammation, plays a central role i...
MST4 Regulates Microglia Neuroinflammation via Targeting PKM2 Nuclear Translocation in Epilepsy: An In Vivo and In Vitro Study [0.03%]
MST4通过靶向PKM2核转位调节癫痫的小胶质细胞神经炎症：体内和体外研究
Jie Fu,Shaotao Zhang,Yifei Chu et al.
Jie Fu et al.
Microglia-mediated neuroinflammation is closely associated with the pathogenesis of epilepsy. Mammalian sterile-20-like kinase 4 (MST4) has been suggested a regulator of inflammation. However, the effect of MST4 on microglia neuroinflammati...
Correction to: Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis [0.03%]
有关DH-217通过靶向IKKβ/Nrf2/HO-1信号轴缓解脑缺血再灌注损伤的更正通知
Mengya Shen,Yuantie Zheng,Ge Li et al.
Mengya Shen et al.
Published Erratum
Neurochemical research. 2026 Jul 1;51(4):206. DOI:10.1007/s11064-026-04832-5 2026
Microglia-Dependent BDNF Signaling in the Dentate Gyrus Underlies the Antidepressant Effects of Gardiquimod, a Toll-Like Receptor 7 Agonist, in Chronically Stressed Mice [0.03%]
小胶质细胞源性脑源性神经营养因子通路介导了 toll 样受体激动剂 gardiquimod 的抗抑郁样作用
Jing Gu,Jin Hong,Xu Lu et al.
Jing Gu et al.
Accumulating evidence suggests that pharmacological restoration of microglial homeostasis in the hippocampus may be a promising strategy for treating depression. In this study, we evaluated whether gardiquimod (GDQ), a selective Toll-like r...
Cryptotanshinone Targets Ferroptosis in Glioma via the EGFR/ROS Signaling Pathway [0.03%]
cryptotanshinone通过EGFR/ROS信号通路靶向胶质瘤铁死亡的作用机制研究
Jiazheng Hu,Xinxin Liang,Yongshi Liao
Jiazheng Hu
To investigate the regulatory effects of cryptotanshinone (CTS) on the biological behavior of glioma cells and its underlying molecular mechanisms, with a particular focus on the role of the epidermal growth factor receptor/reactive oxygen ...
Combined Puerarin and Magnesium Acetyl Taurate Intervention Mitigates Autism-Like Pathology Through Glutamatergic and MAPK Pathway Regulation [0.03%]
红蓝花黄素与乙酰左旋肉碱镁联合干预通过调节谷氨酸能和MAPK信号通路缓解自闭症病理损伤
Sumedha Gupta,Sidharth Mehan,Abhishek Kumar Gupta et al.
Sumedha Gupta et al.
Autism is a multifactorial neurodevelopmental disorder characterized by social deficits, stereotypical behaviour, and neurotransmitter imbalance. This study evaluated the neuroprotective potential of Puerarin (PUN) and Magnesium Acetyl Taur...
Long-Term Impact of Early-Life Stress on Hippocampal Apoptotic Gene Expression in BALB/c Mice [0.03%]
早期应激对BALB/c小鼠海马凋亡基因长期表达的影响
Aida Nurul Barokah,İhsan Kıvanç Gürsoy,Merve Hilal Dönmez et al.
Aida Nurul Barokah et al.
Early-life stress (ELS), such as maternal separation, has been associated with neuronal apoptosis and impaired hippocampal function in rodent models. This study investigated the long-term effects of two ELS paradigms-unpredictable maternal ...
Minute-Resolution Sampling Reveals Rapid and Stimulus-Specific IL-1β Dynamics During Acute Epileptiform Activity [0.03%]
分钟分辨率采样揭示急性癫痫样活动期间快速而特异的IL-1β动态变化
Salvador M Martínez-Gallegos,Laura Medina-Ceja,Alberto Morales-Villagrán et al.
Salvador M Martínez-Gallegos et al.
Brain inflammation is increasingly recognized as a critical contributor to seizure generation and neuronal hyperexcitability. Among proinflammatory mediators, interleukin-1β (IL-1β) has been implicated in epileptogenesis; however, its acu...
Sex-Specific Hippocampal Phosphoproteomic Features Associated with Stress-Induced Phenotypes in Mice Exposed to Chronic Restraint Stress [0.03%]
慢性束缚应激小鼠压力相关表型的性别特异性海马磷酸化蛋白质组特征分析
Yanchen Liu,Tingting Wang,Wenjing Zhao et al.
Yanchen Liu et al.
Chronic stress significantly contributes to anxiodepression, with marked sex differences in hippocampal dysfunction. This study investigated the interplay between sex and stress phenotype in shaping hippocampal phosphorylation landscapes in...