PRMT5 Aggravates Parkinson's Disease Progression Through the Inhibition of Neuronal Autophagy Through DKK1 [0.03%]
脯氨酸残酰胺甲基转移酶5通过DKK1抑制神经元自噬从而加剧帕金森病进展
Houjun Zhou,Hao Fan,Hui Bian et al.
Houjun Zhou et al.
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and severely affects the physical and mental health of patients. The protein arginine methyltransferase 5 (PRMT5) has been shown to be associated with ne...
The Role of Insular Cortex and Prefrontal Cortex in the Pathogenesis of Fibromyalgia: Biochemical and Electrophysiological Rodent Study [0.03%]
岛叶皮质和前额叶皮质在纤维肌痛发病机制中的作用：生化及电生理学的啮齿动物研究
Ahmed F Abouelnaga,Abdelaziz M Hussein,Marwa Abass et al.
Ahmed F Abouelnaga et al.
Neuroimaging implicates the medial prefrontal cortex (mPFC) and insula in fibromyalgia (FM), but synaptic and network mechanisms are unclear. To verify mPFC hypersynapticity in a reserpine-induced FM model and test whether anterior insular ...
Saracatinib Promotes Hippocampal Myelin Regeneration and Oligodendrocyte Precursor Cell Maturation by Inhibiting the NOTCH1 Signaling Pathway in Epileptic Mice [0.03%]
萨拉奇替尼通过抑制NOTCH1信号通路促进癫痫小鼠海马髓鞘再生及少突前体细胞分化成熟
Xinming Luo,Wenyue Wu,Baiqi Yu et al.
Xinming Luo et al.
Genistein Exerts Neuroprotective Effects in an Ouabain-Induced Model of Bipolar Disorder: Behavioral and Molecular Insights [0.03%]
金雀异黄素在箭毒碱诱导的双相情感障碍大鼠模型中的神经保护作用：行为学和分子机制研究
Mariam T Arafat,Heba R Ghaiad,Eman M Elbaz
Mariam T Arafat
Bipolar disorder (BD) is a chronic and prevalent psychiatric disease that has been considered a leading cause of disability among psychiatric conditions. Taking into account that there is yet no satisfactory disease-modifying treatment, we ...
Targeting Liquid-Liquid Phase Separation and Autophagy in Alzheimer's Disease: Insights into Molecular Mechanisms and Therapeutic Potential [0.03%]
针对阿尔茨海默病的液-液相分离和自噬的研究：分子机制及治疗潜力的新见解
Xiaopeng Li,Yan Liu,Hong Hu et al.
Xiaopeng Li et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, marked by cognitive decline and memory loss. Its multifactorial etiology involves genetic, environmental, and cellular factors, with key...
Molecular Mechanisms Underlying Chronic High-Dose Ketamine-Induced Apoptosis in the Hippocampus: A Narrative Review [0.03%]
氯胺酮致海马细胞凋亡的分子机制：叙述性综述
Ali Ahmad Azadbakht,Habibeh Mashayekhi-Sardoo,Yousef Baghcheghi
Ali Ahmad Azadbakht
6-Shogaol Alleviates Post-Cardiopulmonary Resuscitation Brain Injury in Rats by Regulating the miRNA-26a-5p/DAPK1 [0.03%]
姜酚通过调节miRNA-26a-5p/DAPK1信号通路缓解大鼠心肺复苏后脑损伤
Ouyang Rao,Jie Hu,Ning Zhu et al.
Ouyang Rao et al.
This study aims to investigate the neuroprotective effect of 6-shogaol (6-SH) in rats after cardiopulmonary resuscitation (CPR), and to explore the molecular mechanism by which it regulates the miRNA-26a-5p/DAPK1 to inhibit excessive autoph...
Ciwujianoside C Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing Ferroptosis via NNAT-Mediated Inhibition of NF-κB Signaling [0.03%]
NNAT介导的NF-κB信号抑制通过抑制铁死亡减轻Ciwujianoside C对脑缺血再灌注损伤的影响
Weichuan Dai,Yingxian Chen,Wenhua Cai et al.
Weichuan Dai et al.
Cerebral ischemia-reperfusion injury (CIRI) involves oxidative stress, inflammation, and regulated cell death, among which ferroptosis has emerged as a key contributor. However, therapeutic strategies targeting ferroptosis remain limited. T...
Mechanisms of Intermittent Theta-Burst Stimulation Upregulates TFEB and Restores Autophagy to Play a Neuroprotective Role in the Acute Phase After Cerebral Ischemia Reperfusion [0.03%]
间歇θ爆发刺激通过上调TFEB恢复自噬在脑缺血再灌注急性期的神经保护机制研究
Xing-Yu Zhang,Yi-Ning Zhao,Li-Hong Gui et al.
Xing-Yu Zhang et al.
Repetitive transcranial magnetism (rTMS) exerts neuroprotective function in the cerebral ischemia/reperfusion (I/R) injury during the early stage. Intermittent theta-burst stimulation (iTBS), a more time-efficient modality of rTMS, improves...
PAK1 Is Involved in Epileptogenesis by Regulating the Synaptic Plasticity of Hippocampal Neurons Through LIMK [0.03%]
PAK1通过LIMK调节海马神经元的突触可塑性以参与癫痫生成
Fang Lei,Ting Luo,Ling Chen et al.
Fang Lei et al.
PAK1, a key regulator of cytoskeletal remodeling, is associated with synaptic plasticity, but its role in epilepsy remains unclear. This study investigated whether PAK1 contributes to epileptogenesis by modulating hippocampal synaptic plast...