Distinct behaviors of adenylate kinase and cytochrome c observed following induction of mitochondrial permeability transition by Ca(2+) in the absence of respiratory substrate [0.03%]
无呼吸底物时Ca(2+)诱发线粒体渗透性转换后腺苷酸激酶和细胞色素c的不同行为
Takenori Yamamoto,Yuya Yoshimura,Akiko Yamada et al.
Takenori Yamamoto et al.
For induction of the mitochondrial permeability transition (PT) by Ca(2+), the addition of a respiratory substrate such as succinate is required. However, earlier studies indicated the possible induction of the mitochondrial PT by Ca(2+) in...
Catalysis by isolated beta-subunits of the ATP Synthase/ATPase from Thermophilic bacillus PS3. Hydrolysis of pyrophosphate [0.03%]
热栖四联球菌PS3的ATP合酶/ATP酶β亚基单独催化的催化作用：焦磷酸水解
Concepción José-Nuñez,Alfredo Torres-Larios,Leticia Ramírez-Silva et al.
Concepción José-Nuñez et al.
Although the capacity of isolated beta-subunits of the ATP synthase/ATPase to perform catalysis has been extensively studied, the results have not conclusively shown that the subunits are catalytically active. Since soluble F(1) of mitochon...
Effect of monovalent ion adsorption on the electric charge of phosphatidylcholine - decylamine liposomal membranes [0.03%]
单价离子吸附对磷脂酰胆碱-癸胺类脂质体膜电荷的影响
Joanna Kotyńska,Izabela Dobrzyńska,Zbigniew Artur Figaszewski
Joanna Kotyńska
We examined the effect of adsorbed monovalent ions on the surface charge of phosphatidylcholine (PC) - decylamine (DA) liposomal membranes. Surface charge density values were determined from electrophoretic mobility measurements of lipid ve...
Increased vulnerability of brain to estrogen withdrawal-induced mitochondrial dysfunction with aging [0.03%]
雌激素减少诱发的脑线粒体功能障碍随着衰老而增加其脆弱性
Chun Shi,Jie Xu
Chun Shi
In the present study, to determine whether aging could increase the vulnerability of the brain to estrogen withdrawal-induced mitochondrial dysfunction, we measured the cytochrome c oxidase (COX) activity and mitochondrial adenosine triphos...
Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA [0.03%]
3-溴吡喃甲酸诱导的肝癌细胞ROS介导的线粒体凋调亡机制研究
Ji Su Kim,Keun Jae Ahn,Jeong-Ah Kim et al.
Ji Su Kim et al.
Hexokinase type II (HK II) is the key enzyme for maintaining increased glycolysis in cancer cells where it is overexpressed. 3-bromopyruvate (3-BrPA), an inhibitor of HK II, induces cell death in cancer cells. To elucidate the molecular mec...
Mitochondrial generation of reactive oxygen species is enhanced at the Q(o) site of the complex III in the myocardium of Trypanosoma cruzi-infected mice: beneficial effects of an antioxidant [0.03%]
抗氧化剂通过线粒体复合物Ⅲ的细胞色素b560降低感染克氏锥虫小鼠心肌中活性氧水平
Jian-Jun Wen,Nisha Jain Garg
Jian-Jun Wen
In this study, we have characterized the cellular source and mechanism for the enhanced generation of reactive oxygen species (ROS) in the myocardium during Trypanosoma cruzi infection. Cardiac mitochondria of infected mice, as compared to ...
The yeast mitochondrial citrate transport protein: identification of the Lysine residues responsible for inhibition mediated by Pyridoxal 5'-phosphate [0.03%]
丙酮酸脱氢酶抑制机制的研究及维生素B6的结构要求
Sreevidya Remani,Jiakang Sun,Rusudan Kotaria et al.
Sreevidya Remani et al.
The present investigation identifies the molecular basis for the well-documented inhibition of the mitochondrial inner membrane citrate transport protein (CTP) function by the lysine-selective reagent pyridoxal 5'-phosphate. Kinetic analysi...
Relationship between oxidative stress and mitochondrial function in the post-conditioned heart [0.03%]
心肌后处理与氧化应激及线粒体功能之间的关系研究进展
Francisco Correa,Noemí García,Cinthya Robles et al.
Francisco Correa et al.
The pathways activated by post-conditioning may converge on the mitochondria, in particular on the mitochondrial permeability transition pore. We sought to characterize the inhibition status of the mitochondrial permeability transition earl...
W D Frasch
W D Frasch
The Mg2+ dependent asymmetry of the F(1)-ATPase catalytic sites leads to the differences in affinity for nucleotides and is an essential component of the binding-change mechanism. Changes in metal ligands during the catalytic cycle responsi...
Inhibitory Mg-ADP-fluoroaluminate complexes bound to catalytic sites of F(1)-ATPases: are they ground-state or transition-state analogs? [0.03%]
F1-ATP酶催化部位的抑制性Mg-ADP-氟铝酸盐复合物：是稳态类似物还是过渡态类似物？
W S Allison,H Ren,C Dou
W S Allison
Schemes are proposed for coupling sequential opening and closing the three catalytic sites of F(1) to rotation of the gamma subunit during ATP synthesis and hydrolysis catalyzed by the F(o)F(1)-ATP synthase. A prominent feature of the propo...