ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells [0.03%]
ALK5抑制通过调节KLF4介导的糖酵解在BEAS-2B细胞中减少HDM诱导的炎症和氧化损伤
Haixia Wang,Kun Luo,Shasha Li et al.
Haixia Wang et al.
As an important transcription factor, activin receptor-like kinase 5 (ALK5) plays a crucial role in the development of various diseases. However, there have been no reports on whether ALK5 is involved in the pathogenesis of asthma, and furt...
Shionone attenuates endoplasmic reticulum stress-associated ferroptosis in cardiomyocytes by reducing LCN2 and regulating PI3K/Akt signaling [0.03%]
香叶肖竹芸通过降低LCN2和调节PI3K/Akt信号抑制心肌细胞内质网应激相关铁死亡
Chunni Gao,Xingjuan Gao,Jinshuang Li
Chunni Gao
Ischemia/reperfusion-induced myocardial dysfunction remains a clinical problem and is associated to poor outcomes in patients with cardiovascular disorders, such as myocardial infarction. Shionone is a triterpenoid extracted from the herbal...
EMF-induced mesenchymal stem cell migration is mediated by SOCE-dependent calcium influx and modulated by ROCK signaling [0.03%]
由SOCE介导钙内流感应的电磁场诱导的间充质干细胞迁移并由ROCK信号调控
Pin Zhao,Jiayuan Ou,Liming Bai et al.
Pin Zhao et al.
Integrated analysis of RNA-binding proteins in MAFLD: mechanistic insights and diagnostic biomarker potential via alternative splicing [0.03%]
MAFLD中RNA结合蛋白的综合分析：通过可变剪接揭示机制和诊断生物标志物潜力
Panpan Xia,Xiaopeng Li,Jie Peng et al.
Panpan Xia et al.
Metabolic associated fatty liver disease (MAFLD) is a highly prevalent global chronic liver disease. While abnormal expression of RNA-binding proteins (RBPs) has been implicated in MAFLD, their functional roles-particularly in regulating al...
Fisetinidin chloride ameliorates carbon tetrachloride-induced hepatotoxicity in HepaRG cells [0.03%]
菲塞汀氯化物通过改善CCl4致HepaRG细胞肝毒性的效果
Zhen-Bo Wang,Yan-Zhen Zhai,Wei-Qian Deng et al.
Zhen-Bo Wang et al.
Liver diseases poses a significant global health burden. This study investigated the hepatoprotective effects of fisetinidin chloride (FC), a natural flavonoid, against carbon tetrachloride (CCl₄)-induced hepatotoxicity in HepaRG cells, a ...
Astragaloside IV ameliorates cardiomyocyte injury and heart failure through hif/rho/rock pathway regulation: In vitro and in vivo insights [0.03%]
黄芪苷IV通过调节HIF/Rho/Rock通路改善心肌细胞损伤和心力衰竭：体内外研究视角
Gang Li,Min Wang,Qiufen Dong et al.
Gang Li et al.
Heart failure represents the culmination of various cardiovascular diseases, distinguished by a spectrum of complex symptoms. Astragaloside IV (AST-IV) has shown significant cardiac protection in heart failure rats, though the mechanisms ar...
Rab3A attenuated H₂O₂-induced mitochondrial dysfunction and damage in HEI-OC1 cells by stabilizing ITGA3 expression [0.03%]
Rab3A通过稳定ITGA3的表达减轻H2O2诱导的HEI-OC1细胞线粒体功能障碍和损伤
Yanlu Lyu,Daishi Chen,Huihui Liu et al.
Yanlu Lyu et al.
According to reports, Rab3A plays a kay role in various diseases. The regulatory role of Rab3A in hair cell damage and age-related hearing loss has not been explored. HEI-OC-1 cells were treated with hydrogen peroxide (H2O2) to construct a ...
Total favonoids of Desmodium Styracifolium relieve renal ischemia-reperfusion injury by suppressing ferroptosis through P53/SLC7A11/GPX4 signaling pathway : (Running title) TFDS relieved renal ischemia-reperfusion injury [0.03%]
deser素通过抑制P53/SLC7A11/GPX4信号通路介导的铁死亡缓解肾缺血再灌注损伤
Fangchao Yuan,Qiongyao Peng,Qirui Wang et al.
Fangchao Yuan et al.
Renal ischemia/reperfusion injury (RIRI), a common complication of renal transplantation, partial nephrectomy, and transient hypoperfusion, is a major etiological factor of acute kidney injury (AKI) with limited treatment options. Total fla...
Interaction of bile acids with functionally active liver mitochondria: uncoupling activity, detergent effect, and antioxidant action [0.03%]
胆汁酸与功能活跃的肝线粒体相互作用：解偶联活性、去污作用和抗氧化作用
Evgeniya K Pavlova,Victor N Samartsev,Svetlana I Pavlova et al.
Evgeniya K Pavlova et al.
This study investigates the interactions of primary and secondary bile acids (cholic acid (CA), chenodeoxycholic acid (CDCA), ursodeoxycholic acid (UDCA), and lithocholic acid (LCA)) with isolated rat liver mitochondria, focusing on their u...
Fuzheng Huayu recipe inhibits alveolar macrophage M2 polarization and oxidative phosphorylation via METTL3-mediated NDUFA2 m6A modification [0.03%]
扶正化瘀方通过METTL3介导的NDUFA2 m6A修饰抑制肺巨噬细胞M2极化和氧化磷酸化
Yucen Sun,Xinghua Yuan,Weiling Huang et al.
Yucen Sun et al.
Clinical evidence points to the Traditional Chinese Medicine Fuzheng Huayu recipe (FZHYR) as an anti-fibrosis drug. Our previous studies have shown that FZHYR regulates macrophage polarization and the expression of NADH dehydrogenase (ubiqu...