Computational prediction of analog compounds of the membrane protein MCHR1 antagonists ALB-127158 and KRX-104130 [0.03%]
计算预测膜蛋白MCHR1拮抗剂ALB-127158和KRX-104130的类似物化合物
Emrah Sariyer,Ayşegül Saral Sariyer
Emrah Sariyer
Obesity, which is already pervasive throughout the world, endangers public health by raising the prevalence of metabolic disorders and making their treatment more difficult. The development of drugs to treat obesity is a focus of effort. Me...
USP10 suppresses ABCG2-induced malignant characteristics of doxorubicin-resistant thyroid cancer by inhibiting PI3K/AKT pathway [0.03%]
USP10通过抑制PI3K/AKT信号通路抑制ABCG2诱导的多柔比星耐药性甲状腺癌恶性表型
Jianwei Sun,Qian Xiang,Ding Ding et al.
Jianwei Sun et al.
Doxorubicin (DOX) is the most extensively used drug in the chemotherapy of thyroid cancer (TC). However, the existence of DOX resistance is not conducive to TC treatment. Here, we investigated the role of USP10 in DOX-resistant TC and explo...
In vitro evaluation of 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole derivatives against replicative and infective stages of Trypanosoma cruzi [0.03%]
体外评价2-(1h-吡唑-1-基)-1,3,4-噻二唑衍生物对克氏锥虫增殖期和感染期的抑制作用
Ana Flávia Martins Faria,Caroline de Souza Ferreira Pereira,Guilherme Pegas Teixeira et al.
Ana Flávia Martins Faria et al.
Current treatment of Chagas disease (CD) is based on two substances, nifurtimox (NT) and benzonidazole (BZ), both considered unsatisfactory mainly due to their low activities and high toxicity profile. One of the main challenges faced in CD...
Transcriptomics profiling reveal the heterogeneity of white and brown adipocyte [0.03%]
转录组分析揭示白色和棕色脂肪细胞的异质性
Zhongxiao Zhang,Liling Xu,Ling Zhang et al.
Zhongxiao Zhang et al.
The marker genes associated with white adipocytes and brown adipocytes have been previously identified; however, these markers have not been updated in several years, and the differentiation process of preadipocytes remains relatively fixed...
DMPP attenuates lipopolysaccharide-induced lung injury by inhibiting glycocalyx degradation through activation of the cholinergic anti-inflammatory pathway [0.03%]
DMPP通过激活胆碱能抗炎途径抑制糖萼降解从而缓解脂多糖致肺损伤
Feng Qi,Chengwei Duan,Tianpeng Chen et al.
Feng Qi et al.
The study aimed to investigate the therapeutic potential of 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), an agonist of nicotinic acetylcholine receptor (nAChR), in treating acute lung injury (ALI) induced by lipopolysaccharide (LPS). A ...
NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma [0.03%]
NRF2转录调节HJURP抑制口腔鳞状细胞癌铁死亡并参与其发生发展中的作用机制研究
Meixia Zhang,Zhonghou Wang,Guang Yang et al.
Meixia Zhang et al.
Oral squamous cell carcinoma (OSCC) is a common head and neck malignancy with increasing mortality and high recurrence. In this work, we aim to explore the functional role of NFE2 like bZIP transcription factor 1 (NFE2L1) in OSCC progressio...
Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI [0.03%]
Hsa_circ_0052611 和 mir-767-5p 通过调节SCAI指导BRCA细胞的瓦尔堡效应、迁移和侵袭
Xin Wang,Zongwen Liu,Alan Chu et al.
Xin Wang et al.
Noncoding RNAs are key regulators in the Warburg Effect, an emerging hallmark of cancer. We intended to investigate the role and mechanism of circular RNA hsa_circ_0052611 (circ_0052611) and microRNA (miR)-767-5p in breast cancer (BRCA) hal...
Mir-25-3p in extracellular vesicles from fibroblast-like synoviocytes alleviates pyroptosis of chondrocytes in knee osteoarthritis [0.03%]
滑膜成纤维细胞来源的细胞外囊泡中的mir-25-3p通过抑制软骨细胞焦亡来缓解膝骨关节炎
Jianhang Wang,Tao Sun
Jianhang Wang
Knee osteoarthritis (KOA) is defined as a joint disease that occurs mostly among elderly people. Fibroblast-like synoviocytes-derived extracellular vesicles (FLS-EVs) have impacts on the treatment of OA. This study elucidated the mechanism ...
Propionic and valproic acids have an impact on bacteria viability, proton flux and ATPase activity [0.03%]
丙酸和戊二酸对细菌活力、质子通量及ATP酶活性的影响
Heghine Gevorgyan,Tamara Abaghyan,Margarita Mirumyan et al.
Heghine Gevorgyan et al.
Short-chain fatty acids like propionic (PPA) and valproic acids (VP) can alter gut microbiota, which is suggested to play a role in development of autism spectrum disorders (ASD). In this study we investigated the role of various concentrat...
Bidirectional negative feedback actions of DNMT3A and miR-145 in regulating autophagy in cardiac fibroblasts and affecting myocardial fibrosis [0.03%]
DNMT3A与miR-145在心脏成纤维细胞自噬调控中的双向负反馈作用及对心肌纤维化的影响
Shucan Xu,Yonglin Zhang,Guangzhi Zhou et al.
Shucan Xu et al.
Epigenetic regulation has crucial implications for myocardial fibrosis. It has been reported that autophagy, regulated by miR-145, is implicated in the proliferation and fibrosis of cardiac fibroblasts (CFs). However, how it works during th...