Characterization of Perineuronal Nets in the Paraventricular Nucleus of the Hypothalamus and their Alteration in Neurogenic Hypertension [0.03%]
中枢神经系统压力感受性神经元及其在遗传性高血压大鼠中的重塑效应
Ismary Blanco,Sichu Chen,Erin Yeo et al.
Ismary Blanco et al.
Perineuronal nets (PNNs) are key regulators of neuronal excitability, yet whether they are altered during neurogenic hypertension is unknown. Here, we mapped the developmental trajectory of PNNs in the paraventricular nucleus of the hypotha...
Systematic Analysis of SH-SY5Y Differentiation Protocols and Neuronal Subtype Abundance [0.03%]
SH-SY5Y细胞分化诱导神经元类型的系统分析
Marina Prisacar,Svenja Esser,Maximilian Hausherr et al.
Marina Prisacar et al.
The SH-SY5Y cell line is a triple-cloned subline of SK-N-SH cells originally isolated in the early 1970s from a bone marrow biopsy of a four-year-old female patient suffering from neuroblastoma. Since then, this cell line has been used as o...
Fc-Modified IVIG with Enhanced Blood-Brain Barrier Penetration Ameliorates Cognitive Deficits and Neuropathology in A53T α-Synuclein Transgenic Mice [0.03%]
具有增强的血脑屏障渗透性的Fc改造IVIG可改善A53Tα-突触核蛋白转基因小鼠的认知障碍和神经病理学
Jie Zhu,Ya-Ru Huang,Mei-Qi Wang et al.
Jie Zhu et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by degeneration of nigrostriatal dopaminergic neurons together with α-synuclein (α-syn) aggregation, neuroinflammation, and oxidative stress. Although intravenous...
LPS-Induced Neuroinflammation Disrupts Brain-Derived Neurotrophic Factor and Kinase Pathways in Alzheimer's Disease Cell Models [0.03%]
LPS诱导的神经炎症会破坏阿尔茨海默病细胞模型中的神经营养因子和激酶途径
Behrouz Shademan,Hadi Yousefi,Rahim Sharafkhani et al.
Behrouz Shademan et al.
Alzheimer's disease (AD) leads to a progressive loss of cognitive abilities and memory. A critical factor now recognized as driving AD pathology is neuroinflammation-inflammation occurring in the nervous system, which contributes to neurona...
Research on the Application of Mesenchymal Stem Cells for Addressing Mitochondrial Damage in Neurodegenerative Diseases [0.03%]
间充质干细胞修复神经退行性疾病线粒体损伤的研究进展
Li Zhang,Ying Ge,Jingjing Wu et al.
Li Zhang et al.
Neurodegenerative diseases (NDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) pose serious threats to human health, and their pathogenesis is closely related to mitochondrial damage. Mitochondrial dysfunction includes abnor...
Systematic Review on Neurotoxic Implications of Lead-Induced Gene Expression Alterations in the Etiology of Alzheimer's Disease [0.03%]
系统综述：铅诱导的基因表达改变对阿尔茨海默病神经毒性的意义在病因学中的作用
Aluru Parithathvi,P Harshitha,Kamalesh Dattaram Mumbrekar et al.
Aluru Parithathvi et al.
Lead (Pb) is a hazardous heavy metal frequently used because it is readily available and inexpensive. Due to contaminated soil, dust, and items like paints and batteries, lead exposure is still an issue of concern in many nations. There is ...
Microcargos with Megaeffects: A Literature Review of Immunomodulatory, Diagnostic, Prognostic, and Therapeutic Dimensions of Exosomal MicroRNAs in Glioblastoma Multiforme [0.03%]
微小载体与巨大效应：胶质母细胞瘤免疫调节、诊断、预后和治疗维度的外泌体microRNA文献回顾
Amirhossein Kamroo,Arash Esmaeili,Kiana Tahan et al.
Amirhossein Kamroo et al.
Glioblastoma multiforme (GBM) is a complex and aggressive central nervous system (CNS) tumor that has a poor prognosis, and restricted therapeutic options are available despite the increasing research conducted. Moreover, the cells in our b...
Extracellular Matrix (ECM)-Regulated Molecular Switches: Tissue Inhibitors of Metalloproteinases in Synaptic Formation and Neuropathic Diseases [0.03%]
extracellular matrix（细胞外基质）调控的分子开关：金属蛋白酶组织抑制剂在突触形成及神经性疾病中的作用
Shuchang Qi,Siyao Wang,Yishan Tan et al.
Shuchang Qi et al.
Synaptic formation, the cornerstone of neurological function, underpins complex behaviors and cognitive processes, with structural/functional aberrations implicated in neurodevelopmental disorders and neurodegenerative pathologies. Synaptog...
Identification of Key Ferroptosis-Related Genes as Potential Diagnostic Biomarkers for Ischemic Stroke: Evidences from Integrated Bioinformatics Analysis and Experiments [0.03%]
整合生物信息学分析和实验识别缺血性卒中铁死亡相关关键基因作为潜在诊断标志物的证据
Nan Tang,Yin Shen
Nan Tang
Ferroptosis, an iron-dependent form of regulated cell death, has been linked to the occurrence and progression of ischemic stroke (IS). This study aims to uncover the key ferroptosis-related genes in IS and their correlations with immunoinf...
In Utero Electroporation Uncovers an Early-Differentiating Subset of Dentate Gyrus Progenitors [0.03%]
孕期电穿孔法发现齿状 gyrus 前体细胞的早期分化亚群
Hiroshi M Shinohara,Tokiharu Takahashi
Hiroshi M Shinohara
The dentate gyrus of the hippocampus develops through complex cellular migrations and differentiations, which have been primarily characterized using genetic lineage tracing approaches. Through systematic application of in utero electropora...