Regulatory Functions of Long Non-coding RNAs and Circular RNAs in the Molecular Pathogenesis of Autism Spectrum Disorder [0.03%]
长非编码RNA和环状RNA在自闭症分子发病机制中的调控功能
Juhyun Song,Young-Kook Kim
Juhyun Song
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic basis. There is increasing evidence that long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) play key roles in ASD pathophysiology. This ...
Diverse Effects of Various Toll-Like Receptor 2 Ligands on Neuronal Activity and Cell Death [0.03%]
各种 Toll 样受体 2 配体对神经元活性和细胞死亡的多种影响
Futa Sato,Satoshi Hachimura
Futa Sato
The role of Toll-like receptor 2 (TLR2) in the central nervous system (CNS) is critical in several conditions including neurological disorders such as pain, and neurodegenerative disorders such as Parkinson's disease. Therefore, understandi...
Ferroptosis in Neonatal Hypoxic-Ischemic Encephalopathy: Mechanisms and the Therapeutic Potential of Vitamin D/VDR Signaling [0.03%]
维生素D/VDR信号在新生儿缺氧缺血性脑病铁死亡中的机制作用及治疗潜力
Yueju Cai,Wei Zhou
Yueju Cai
As a major neonatal brain disorder, hypoxic-ischemic encephalopathy(HIE) presents with elevated risks of long-term disability and neonatal death. Ferroptosis is a distinct mode of regulated cell death marked by excess intracellular iron, ox...
Non-coding RNAs in Parkinson's Disease: Pathogenesis, Exosomes, and Therapeutic Horizons [0.03%]
帕金森病中的非编码RNA：发病机制、外泌体与治疗前景
Niloufar Rezaei,Maryam Zivari,Mansure Kazemi et al.
Niloufar Rezaei et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of α-synuclein. Non-coding RNAs (ncRNAs)-including microRNAs, long non-coding RNAs, and circular RN...
Tau-Mitochondria Interactions in Neurodegeneration: Mechanisms and Therapeutic Potential [0.03%]
tau-线粒体相互作用在神经退行性疾病中的机制和治疗潜力
Yaisa Castillo-Casaña,Clorinda Arias,Roberto Coria
Yaisa Castillo-Casaña
Tau is a microtubule-associated protein encoded by the MAPT gene and is mainly expressed in neurons. Alternative splicing generates preferentially six isoforms differing in N-terminal inserts (0, 1, or 2N) and microtubule-binding repeats (3...
Dual-Omics Mapping of Tinnitus Phenotype Transition in Noise-Exposed Auditory Cortex [0.03%]
噪声暴露下听觉皮层耳鸣表型转换的双组学图谱研究
Zhixin Zhang,Xinmiao Xue,Peng Liu et al.
Zhixin Zhang et al.
Noise-induced hearing loss (NIHL) is a primary contributor to tinnitus, involving mechanisms such as inflammatory damage, central sensitization, and auditory cortex remodeling. However, not all cases of tinnitus are accompanied by NIHL, and...
Exploring Neural Stem Cell Therapies as Innovative Treatments for Glioblastoma [0.03%]
探究神经干细胞疗法作为胶质母细胞瘤的创新治疗方法
Marola Fawzy,Hend M ElTayebi,Amany Samir
Marola Fawzy
Glioblastoma (GB) is among the most aggressive and treatment-resistant brain tumors, largely due to its heterogeneous tumor microenvironment (TME) and the protective nature of the blood-brain barrier (BBB). Recent advances have highlighted ...
Identification of Copper and Iron Metabolism Related Biomarkers in Alzheimer's Disease [0.03%]
阿尔茨海默病中与铜铁代谢相关生物标志物的识别
Dandan Huang,Shasha Huang,Yunhan Gao et al.
Dandan Huang et al.
Alzheimer's disease (AD) is a complex neurodegenerative disorder. Recent studies have demonstrated that the dysregulated metabolism of metal ions, particularly copper and iron imbalance in the brains of AD patients, is closely associated wi...
Comprehensive Molecular Evaluation of Transcription Factor 7-like 2, Long Noncoding RNA (ANRIL), and CYP2C19*17 Gene Variants and Their Association with Predisposition and Progression in Stroke Patients [0.03%]
转录因子7样分子2、长链非编码RNA（ANRIL）及CYP2C19*17基因多态性在脑卒中患者发病与预后中的作用机制研究
Abdullah Hamadi,Rashid Mir,Osama M Al-Amer et al.
Abdullah Hamadi et al.
Stroke is a health problem all over the world. It is a primary cause of disability and ranked number two death cause. In kingdom of Saudi Arabia KSA, the prevalence of stroke in the KSA estimated to be more than 40 per 100 thousand in 2021....
Characterization of Perineuronal Nets in the Paraventricular Nucleus of the Hypothalamus and their Alteration in Neurogenic Hypertension [0.03%]
中枢神经系统压力感受性神经元及其在遗传性高血压大鼠中的重塑效应
Ismary Blanco,Sichu Chen,Erin Yeo et al.
Ismary Blanco et al.
Perineuronal nets (PNNs) are key regulators of neuronal excitability, yet whether they are altered during neurogenic hypertension is unknown. Here, we mapped the developmental trajectory of PNNs in the paraventricular nucleus of the hypotha...