First Evidence of Functional Neuronal Remodeling In Vitro in a Cell Line from an Evolutionarily Ancient Vertebrate (Sturgeon) [0.03%]
濒危鱼类鲟鱼细胞系的体外功能性神经重塑现象研究首次取得证据
Bianka Grunow,Jonna Schulz-Ehlbeck
Bianka Grunow
The targeted differentiation of stem cell-like cells into functional neurons is a central goal in developmental biology and comparative neurobiology. In this study, we report for the first time on the successful neuronal remodeling of cell ...
A Bibliometric Analysis of Publications on Macrophages in Peripheral Nerve Injury [0.03%]
外周神经损伤巨噬细胞文献的 bibliometrix 绘图分析研究进展
Qingyi Huo,Mingyang Li,Yibo Zhao et al.
Qingyi Huo et al.
Peripheral nerve injury (PNI) disrupts nerve function, there has been increasing focus on the role of macrophages in PNI. This study provides a comprehensive analysis of research trends and key topics related to macrophages in the field of ...
Patient-Derived PSEN1 Cerebral Organoids Revealed Parallel Development of Amyloid-β Accumulation and Network Dysfunction [0.03%]
基于患者衍生的PSEN1脑类器官揭示了淀粉样蛋白-β积累和神经网络功能障碍的同时发展
Andrijana Angelovski,Hana Hribkova,Jiri Sedmik et al.
Andrijana Angelovski et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by progressive dementia, brain atrophy, and ultimately death. Using cerebral organoids derived from human-induced pluripotent stem cells (hiPSCs) carrying the familial P...
Monomethyl Fumarate Modulates Iron Metabolism and Mitochondrial Function in Microglia with Implications for Multiple Sclerosis Progression [0.03%]
单甲基富马酸调节微胶质细胞中铁代谢和线粒体功能以及其对多发性硬化病进展的影响
Justus Dann,Katharina Klöster,Ulas Ceylan et al.
Justus Dann et al.
Fumaric acid esters have proven to be effective medications in relapsing-remitting multiple sclerosis with neuroprotective effects. In this study, we investigated the impact of fumaric acid esters on primary murine microglia in vitro compar...
The CRF‑CRFR1 Axis Mediates Prenatal Fear Stress‑Induced Hippocampal Mitochondrial Damage in Offspring via MAM Remodeling and Calcium Overload [0.03%]
CRF-CRFR1轴通过MAM重塑和钙超载介导 prenatal 恐惧应激诱导的后代海马线粒体损伤
Yu-Jie Li,Li-Ping Yang,Yun-Yu Wang et al.
Yu-Jie Li et al.
Mitochondrial dysfunction has been recognized as one of the three hallmark biological features of autism spectrum disorder. This study is intended to investigate the molecular mechanisms underlying prenatal psychological fear stress‑induce...
Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring [0.03%]
等卡路里的单糖饮食可重塑大鼠后代海马背腹成熟及腹侧可塑性
Kacper Witek,Karolina Wydra,Luca Bonfanti et al.
Kacper Witek et al.
Early-life nutrition is increasingly recognized as a key determinant of brain developmental trajectories. Because the dorsal (dHIP) and ventral (vHIP) hippocampus regulate distinct cognitive and emotional functions, understanding how matern...
Causal Relationship Between Circulating Leukocyte Characteristics and Immune Cell Traits With Multiple Sclerosis Risk: A Two-Sample Bidirectional Mendelian Randomisation Study [0.03%]
循环白细胞特征与免疫细胞特性对多发性硬化发病风险因果关系的两样本双向孟德尔随机化研究
Jia-Jia Yun,Ya-Lei Li,Jing-Man Qiu et al.
Jia-Jia Yun et al.
The present study aimed to investigate MR-based evidence for potential causal relationships between circulating leukocytes, immune cell traits, and multiple sclerosis (MS) using a two-sample, bidirectional Mendelian randomisation (MR) appro...
Human iPSC-Derived Spinal Neurons Carrying the ALS FUS (P525L) Mutation Exhibit Lower Response to Inhibitory Neurotransmitters [0.03%]
携带ALS FUS(P525L)突变的人诱导多能干细胞来源的脊髓神经元对抑制性神经递质的反应较低
Tiziano D&#x;Andrea,Maria Cristina Benedetti,Michela Mochi et al.
Tiziano D&#x;Andrea et al.
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disorder characterized by motoneurons degeneration. Functional studies have linked ALS to hyperexcitability and excitotoxicity, but the cause of the disease is unknown, thou...
Anja Suhadolc,Selena Horvat,Janko Kos et al.
Anja Suhadolc et al.
Glial cells, namely microglia, astrocytes, and oligodendrocytes, play crucial roles in maintaining homeostasis in the central nervous system and orchestrating responses to injury, infection, and disease. Among the molecular regulators of gl...
Fingolimod Acutely Facilitates the Activation of TRKB in a BDNF-dependent Manner [0.03%]
芬戈莫德通过依赖脑源性神经营养因子的方式急性促进TRKB活化
Cecilia Anna Brunello,Paula Pastor Muñoz,José Pedro Araujo et al.
Cecilia Anna Brunello et al.
Fingolimod (FNG) is a sphingosine-1-phosphate receptor agonist currently prescribed for the treatment of remitting-relapsing multiple sclerosis. However, an increasing body of evidence indicates that FNG has a variety of other effects on th...