Uncovering Proteomic and Biochemical Alterations in Plasma from Lesch-Nyhan Disease Patients [0.03%]
揭示Lesch-Nyhan病患者血浆蛋白质组和生化改变
Sundas Javed,Daniela Braconi,Haidara Nadwa et al.
Sundas Javed et al.
Lesch-Nyhan disease (LND) is an ultra-rare X-linked inborn error of metabolism caused by complete or partial deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT), a key enzyme in the purine salvage pathway. This defect leads ...
Research Progress of Lipid Metabolism-Mediated Neuroinflammation in Alzheimer's Disease [0.03%]
阿尔茨海默病中脂质代谢介导的神经炎症的研究进展
Yuzhen Shen,Xiaoran Wang,Xinyu Liu et al.
Yuzhen Shen et al.
Alzheimer's disease (AD) is a neurodegenerative disease closely associated with age. The main clinical manifestations include cognitive impairment, including visuospatial ability, memory, language, and behavioral disorders. These manifestat...
Advances in Bionic Therapies for Targeting Neural Circuit Reconstruction and Integration for Spinal Cord Injury [0.03%]
脊髓损伤靶向神经环路重建与整合仿生治疗学进展
Tao Li,Zhi-Hong Zhao,Hai-Bin Tang et al.
Tao Li et al.
Spinal cord injury (SCI) is one of the most common critical illnesses, which can cause neurological deficits and disabilities of motor, sensory and autonomic nervous system in mild cases, and lead to paralysis or even death following severe...
Wei Li,Xianning Wang,Jiannan Liu et al.
Wei Li et al.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Extracellular senile plaques composed of amyloid-β (Aβ) peptides, intracellular neurofibrillary tangles (NFTs) containing the hyperphosphorylated tau protein, excessi...
Integrated Bioinformatics Analysis of Differentially Expressed RNA-Binding Proteins in Human Gliomas [0.03%]
人类胶质瘤差异表达RNA结合蛋白的综合生物信息学分析
Shafiul Haque,Darin Mansor Mathkor,Ashjan Saeed Babegi et al.
Shafiul Haque et al.
Gliomas are complex and among the most lethal central nervous system (CNS) disorders. While they are notoriously heterogeneous, evidences suggest critical involvement of intricate interactions between RNA-binding proteins (RBPs) and their d...
Peripheral Parasympathetic Networks in Pain: A Systems-Level Review of Mechanisms and Modulations [0.03%]
外周副交感神经网络在疼痛中的作用：机制和调节的系统综述
Ruihan Yang,Shilin Jia,Yuanyuan Li et al.
Ruihan Yang et al.
The parasympathetic nervous system (PNS), a division of the autonomic nervous system, maintains physiological homeostasis within the body. The PNS seems to influence the processing of nociceptive information. A growing body of research indi...
Interaction Between Microglial Lipid Droplet Metabolism and Immune Polarisation After Stroke: Mechanisms and Therapeutic Prospects [0.03%]
中风后小胶质细胞脂滴代谢与免疫极化相互作用：机制和治疗前景
Junchi Yang,Dongyan Wang,Xu Dong et al.
Junchi Yang et al.
The interaction between lipid droplet (LD) metabolism and immune polarisation of microglia after stroke plays a key role in the regulation of neuroinflammation and tissue repair. This review analysed the molecular mechanism, spatiotemporal ...
HIV-1 Tat Protein Exposure Alters the Morphological Characteristics and Gene Expression in the Primary Mouse Cortex Endothelial Cells and Human Brain Microvascular Endothelial Cells [0.03%]
HIV-1 Tat蛋白改变小鼠皮层内皮细胞和人脑微血管内皮细胞的形态特征及基因表达模式
Lili Quan,Ichiro Manabe,Rieko Muramatsu et al.
Lili Quan et al.
HIV-1-associated neurocognitive disorders (HAND) are highly prevalent in the era of combination of antiretroviral therapies. Recent studies suggest that damage of blood-brain barrier (BBB) may serve as an early biomarker of cognitive dysfun...
Proteomic Analysis of Mouse Cerebral Cortex Following Experimental Ischemic Stroke: Identifying Novel Biomarkers of Damage and Repair [0.03%]
缺血性卒中后小鼠大脑皮质的蛋白质组分析：发现损伤和修复的新生物标志物
Dominik Hamer,Ana Butorac,Daniela Petrinec et al.
Dominik Hamer et al.
Stroke remains a major global health challenge due to its high mortality and significant socioeconomic burden. Despite advances in clinical management, effective diagnostic tools and therapeutic strategies remain limited. This study aimed t...
Comprehensive and In-Depth Molecular and Pathway Studies of the Hippocampus in Alzheimer's Disease [0.03%]
阿尔茨海默病海马的全面深入分子及途径研究
Farnaz Tayani Pour,Fatemeh Saadatpour,Ali Salari
Farnaz Tayani Pour
Alzheimer's disease (AD) still lacks a conclusive treatment, largely due to an incomplete understanding of the molecular mechanisms involved. To enhance our knowledge of AD pathogenesis and identify potential therapeutic targets, this study...