Cerebral Hypoperfusion Causes Behavioral Changes and Impairs the Rod Photoreceptor Pathway in the Retina of Aged Mice [0.03%]
脑低灌注引起行为改变并损害小鼠视网膜rod光感受器通路
Spencer Talmage Barney,Daniela Becerril,Sheelu Monga et al.
Spencer Talmage Barney et al.
Gradual reduction of cerebral blood flow occurs with aging, and it is a major cause of vascular dementia, a group of dementias with a cerebrovascular component. Interestingly, patients who have suffered a vascular insult may develop retinop...
Microglial Autofluorescence in the Brain and Retina is Dynamically Modulated by Systemic Inflammation [0.03%]
全身性炎症动态调节大脑和视网膜的小胶质细胞自发荧光
Mary Slayo,Hasan Ul Banna,Ying Zhi Cheong et al.
Mary Slayo et al.
The retina-an extension of the central nervous system-contains microglia that survey and respond to injury or pathogens. In response to their environmental milieu, these cells accumulate autofluorescent material likely reflective of cellula...
Unravelling Synaptic and Metabolic Mechanisms of Cognitive Resilience in Asymptomatic Alzheimer's Disease Across Two Alzheimer's Disease Cohorts [0.03%]
无症状阿尔茨海默病两种阿尔茨海默病队列中认知坚韧的突触和代谢机制解析
Rümeysa Aksu,Hatice Büşra Lüleci,Tunahan Çakır
Rümeysa Aksu
Asymptomatic Alzheimer's Disease (AsymAD) is a preclinical stage of Alzheimer's Disease (AD) identified by amyloid plaques and neurofibrillary tangles in cognitively normal individuals and offers essential understanding for early diagnosis ...
Chan-Il Choi,Ha Neui Kim,Hyesook Yoon et al.
Chan-Il Choi et al.
Identification of Biomarkers Associated With Copper Metabolism in Ischemic Stroke Through Bulk RNA Sequencing and Mendelian Randomization Analysis [0.03%]
通过RNA测序和孟德尔随机化分析鉴定与缺血性卒中铜代谢相关的生物标志物
Ruizhe Yang,Xin Zhou,Zhiheng Zhao et al.
Ruizhe Yang et al.
Digging Deep into Alzheimer Disease: How Electron Microscopy Helps Elucidating Its Pathogenesis [0.03%]
深入探究阿尔茨海默病：电子显微镜如何帮助阐明其发病机制
Sveva Dallere,Antonio Migheli,Alessandro Vercelli
Sveva Dallere
Alzheimer disease (AD), first described by Alzheimer and Perusini in the early twentieth century, is a devastating neurodegenerative disorder without a definitive cure. Unraveling the subcellular alterations underlying AD is essential to el...
Interactions Between Perioperative Anesthesia Management and Gut Microbiota: Current Research Advances [0.03%]
围术期麻醉管理与肠道菌群的相互作用：目前研究进展
Naiqi Jiang,Lei Wang,Xiaodi Chen et al.
Naiqi Jiang et al.
The gut microbiota (GM), a complex and diverse microbial community residing in the digestive tract, plays a pivotal role in human health and disease. Recent studies have revealed a strong association between the GM and overall health, with ...
Cooperation of Transcription Factor PAX6 with Chromatin-Remodeling Complex BAF During Embryonic Development in Mammals [0.03%]
转录因子PAX6与染色质重塑复合物BAF在哺乳动物胚胎发育中的合作作用
Asya Azieva,Tatyana Vasilyeva,Oksana Maksimenko et al.
Asya Azieva et al.
Entorhinal Cholecystokinin in Alzheimer's Disease: Its Earliest Vulnerability and Rescue Effects Across Different Disease Stages in a Mouse Model [0.03%]
胆囊收缩素在阿尔茨海默病内侧隔核的最早期易损性和不同疾病阶段的小鼠模型中的修复效应
Yixuan Sui,Nan Zhang,Xi Chen et al.
Yixuan Sui et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline. The entorhinal cortex (Ent) is among the earliest affected regions, and its neuropeptide cholecystokinin (CCK) supports neocortical-ass...
Immunometabolism Reframes Alzheimer's Disease: From Systemic Dysmetabolism to Glial Rewiring [0.03%]
免疫代谢重新定义阿尔茨海默病：从全身性代謝異常到神經膠質重聯 Wiring/glial rewiring在這里指的是神经胶质的重新连接或重组，但直译可能不太符合中文表达习惯，此处翻译为“重联”是为了保留原意，如果需要更通俗的表达可以考虑调整。整体上，“Immunometabolism Reframes Alzheimer's Disease: From Systemic Dysmetabolism to Glial Rewiring" 可以理解为“免疫代谢重新定义阿尔茨海默病：从全身性代謝異常到神經膠質重聯”。
Duc-Hiep Bach,Thanh Liem Nguyen
Duc-Hiep Bach
Alzheimer's disease (AD) is increasingly recognized as a disorder of dysregulated immunometabolism at the neurovascular-glia-neuron interface. Systemic metabolic stressors such as insulin resistance, dyslipidaemia, and obesity converge on b...