Stage-Dependent Disruptions in Neurogenesis and Neurotrophins' Production Following Prenatal and Postnatal Valproic Acid Exposure: Implications for Autism Spectrum Disorders [0.03%]
妊娠期和产后服用丙戊酸钠对神经发生及神经营养素生成的阶段依赖性干扰及其对于自闭症谱系障碍的意义
Katarine Fereshetyan,Margarita Danielyan,Konstantin Yenkoyan
Katarine Fereshetyan
Autism spectrum disorders (ASD) are neurodevelopmental conditions involving impaired neuronal processes such as connectivity, synaptogenesis, and migration. Prenatal exposure to valproic acid (VPA), an anticonvulsant and mood stabilizer, is...
Chronic Neuroplasticity Changes Following Neurotropic Viral Infection: Mechanisms and Implications [0.03%]
神经趋向性病毒性感染后的慢性神经可塑性变化：机制及意义
Aria Mohabbat,Hossein Bannazadeh Baghi
Aria Mohabbat
The nervous system exhibits remarkable adaptability through neuroplasticity, which allows for structural and functional changes in response to intrinsic and extrinsic stimuli. This dynamic process underpins synaptic formation, elimination, ...
Causal Effect of Blood Cell Perturbation Phenotypes on Multiple Sclerosis via Immune Mediation: A Mendelian Randomization Study [0.03%]
基于免疫介导的血细胞扰动表型对多发性硬化的因果效应研究：孟德尔随机化研究
Jia-Jia Yun,Jin-Qiu Wang,Jia-Hui Wang et al.
Jia-Jia Yun et al.
Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system, characterized by myelin damage caused by immune dysfunction and genetic factors. Nevertheless, the role of peripheral blood and immune cells in the ...
Histone Arginine Methylation Regulates Neuropeptide Y Expression in the Basolateral Amygdala to Promote Reward-Seeking Behaviour [0.03%]
基底外侧杏仁核组蛋白精氨酸甲基化通过调节神经肽Y的表达促进觅奖行为
Sneha Sagarkar,Deepa Rotti,Sahil Raykar et al.
Sneha Sagarkar et al.
The basolateral amygdala (BLA) serves in the evaluation of reward. However, the causal molecular substrates in the BLA necessary for reward seeking behaviour are largely unknown. Reward conditioning induces long-lasting changes in epienzyme...
Neuroprotective Effects of the Nonsteroidal Anti-inflammatory Drug Celecoxib Against Caspase-1-dependent Pyroptosis Partially by Suppressing the HMGB1/TLR4 Pathway [0.03%]
COX-2抑制剂塞来昔布通过抑制HMGB1/TLR4信号通路对抗caspase-1依赖性焦亡的神经保护作用
Yu Sun,Shucai Jiang,Yan Feng et al.
Yu Sun et al.
This study evaluated the protective effects of celecoxib on epilepsy and explore its potential involvement in regulating pyroptosis and the high mobility group box 1 (HMGB1)/Toll-like receptor 4 (TLR4) signaling pathway. Adult male Sprague-...
Short-Chain Fatty Acids as a Therapeutic Strategy in Parkinson's Disease: Implications for Neurodegeneration [0.03%]
短链脂肪酸作为帕金森病的治疗策略：对神经退行性疾病的启示
Abinash Ravi,Suganiya Umapathy,Ieshita Pan
Abinash Ravi
Neurodegeneration involves the progressive deterioration of neuronal structure and function, leading to deficits in cognition, motor skills, and other neurological processes. Parkinson's disease (PD) is notably prevalent among neurodegenera...
Microglia-Derived Extracellular Vesicles Enhance Oligodendrocyte Maturation by Transcriptionally Regulating Mitochondrial Molecular Pathways [0.03%]
小胶质细胞源性外泌体通过转录调节线粒体分子途径促进少突胶质细胞成熟
Stefano Raffaele,Marta Lombardi,Davide Marangon et al.
Stefano Raffaele et al.
Degeneration of myelinating oligodendrocytes and the resulting breakdown of the myelin sheath are key drivers of neurodegeneration and disability across numerous central nervous system pathologies. Thus, a compelling strategy to preserve ne...
A MGMT Enhancer Variant is Associated with Glioma Susceptibility and Progression [0.03%]
MGMT增强子多态性与胶质瘤易感性和进展相关性研究
Shu Zhang,Yiji Chen,Wenshen Xu et al.
Shu Zhang et al.
The O6-methylguanine-DNA methyltransferase (MGMT) plays a significant role in the pathogenesis and progression of glioma. Numerous enhancer variants, including those within the MGMT gene region and adjacent gene regions, have been found to ...
Co-treatment Strategy Supports Neuroprotection by Intersecting p62-Keap1-NRF2 and Autophagy Signaling Pathways in the Cellular Model of Parkinson's Disease [0.03%]
交集p62-Keap1-NRF2和自噬信号通路的联合治疗策略支持帕金森病细胞模型中的神经保护作用
Oliwia Koszła,Przemysław Sołek,Krzysztof Jóźwiak
Oliwia Koszła
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by neuronal loss, attributed largely to oxidative stress and mitochondrial dysfunction. This study explores the synergistic neuroprotective effects of resver...
A Multi-omics Exploration Revealing SLIT2 as a Prime Therapeutic Target for Peripheral Facial Paralysis: Integrating Single-Cell Transcriptomics and Plasma Proteome Data [0.03%]
整合单细胞转录组和血浆蛋白组数据揭示SLIT2是外周性面瘫的关键治疗靶点
Yuchao Liu,Chunli Li,Linli Yao et al.
Yuchao Liu et al.
Peripheral facial paralysis (PFP) is a common neurological disorder characterized by facial-nerve dysfunction. Identifying therapeutic targets and understanding the molecular and cellular mechanisms underlying PFP are crucial for developing...