EGR1/miR-4306/MAT2A axis aggravates pyroptosis and extracellular matrix degradation of nucleus pulposus cells in intervertebral disc degeneration [0.03%]
EGR1/miR-4306/MAT2A轴加重椎间盘退变髓核细胞焦亡和细胞外基质降解
Sujun Qiu,Wenning Xu,Cheng Yu et al.
Sujun Qiu et al.
Background: Intervertebral disc degeneration (IVDD) acts as the prerequisite and pathological basis for a series of spinal degenerative diseases, and it remains one of the most harmful and difficult-to-treat conditions in...
NAA20-mediated ACF1 lactylation drives neuroblastoma progression through enhancing GCLM-dependent glutathione synthesis [0.03%]
NAA20介导的ACF1乳酸化通过增强GCLM依赖性的谷胱甘肽合成驱动神经母细胞瘤的发展进展
Bingqiang Han,Min Xu,Qi Wang et al.
Bingqiang Han et al.
Neuroblastoma (NBL) is a pediatric malignancy with poor prognosis in high-risk cases. This study explores the function of albumin conformation factor 1 (ACF1) in NBL progression and delves into the underpinning mechanism. Exome and transcri...
METTL7B-stabilized lncRNA-MIR22HG to drive p53-mediated neuronal apoptosis via the ubiquitinating JARID2 in cerebral ischemia/reperfusion injury [0.03%]
METTL7B稳定化的lncRNA-MIR22HG通过泛素化JARID2驱动p53介导的神经元凋亡在脑缺血再灌注损伤中的作用
Hao Zhang,Meng Li,Yilin Wu et al.
Hao Zhang et al.
Ischemic stroke (IS) constitutes a leading driver of mortality and morbidity worldwide, with neuronal apoptosis representing a key pathological process. Accordingly, our objective was to delve into the implications of a novel signaling axis...
LncRNA-Gm5532 deficiency alleviates bone resorption by inhibiting mitochondrial respiration through iASPP/NRF2 [0.03%]
长链非编码RNA-Gm5532通过iASPP/NRF2抑制线粒体呼吸从而缓解骨吸收缺陷
Jian Zhang,Xingtao Zhang,Lingyan Zhang et al.
Jian Zhang et al.
Osteoporosis, characterized by excessive osteoclast activity and bone resorption, is closely linked to mitochondrial respiration. The long non-coding RNA Gm5532 (Gm5532) has been implicated in osteoclast differentiation, but its role in mit...
HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity [0.03%]
HUWE1通过调节线粒体自噬保护多巴胺能神经元免受6-HOCA和MPP+诱导的神经毒性损伤
Chanhaeng Lee,Dong Yeol Kim,Sang-Min Kim et al.
Chanhaeng Lee et al.
Parkinson's disease (PD) is characterized by dopaminergic neuronal loss, often associated with mitochondrial dysfunction and impaired mitophagy. Here, we investigated the role of HUWE1, an E3 ubiquitin ligase, in regulating mitophagy and ne...
Ferritinophagy: molecular mechanisms and its crosstalk with ferroptosis in chronic respiratory diseases [0.03%]
铁死亡与肺部疾病中铁蛋白的作用及分子机制
Junjie Ning,Limei Wen,Lina Qiao
Junjie Ning
Ferritinophagy, a selective autophagic process mediated by nuclear receptor coactivator 4 (NCOA4), plays a central role in maintaining cellular iron homeostasis by degrading ferritin and releasing stored iron. Under physiological conditions...
Synovial macrophage rhoa protects against osteoarthritis by suppressing YAP/IL-17C mediated chondrocyte senescence [0.03%]
滑膜巨噬细胞rhoa通过抑制YAP/IL-17C介导的软骨细胞衰老保护关节免于发生骨关节炎
Yizhou Xu,Shuyi Xu,Jiayi Li et al.
Yizhou Xu et al.
Objective: The GTPase RhoA is known as a regulator involved in cartilage degeneration and subchondral bone remodeling related to osteoarthritis (OA). However, its specific role in synovial macrophages, the key immune cell...
Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation [0.03%]
重复暴露于氯胺酮可通过多巴胺受体DRD1介导的Akt/Gsk-3β磷酸化抑制诱导小鼠产生类似焦虑的行为和神经元凋亡
Jia-Yi Wei,Peng Lv,Jiayu Zhang et al.
Jia-Yi Wei et al.
Repeated exposure to ketamine leads to mental behavioral disorders and cognitive deficits in mice. As a neurotransmitter receptor, dopamine receptor 1 (DRD1) is involved in mental regulation and memory formation. However, the role of DRD1 i...
Machine learning-guided Nano-QSAR modeling predicts HepaRG cell membrane toxicity of engineered nanoparticles with mechanistic insights [0.03%]
机器学习指导的Nano-QSAR模型预测工程纳米颗粒的HepaRG细胞膜毒性及作用机制
Xinyu Hao,Ting Ren,Shuo Chen et al.
Xinyu Hao et al.
Engineered nanoparticles (ENPs), defined as nanoscale materials with at least one dimension between 1 and 100 nm, exhibit multifunctional and tunable physicochemical properties, that are at the center of several innovative fields. However, ...
Acute myeloid leukemia (AML)-derived bone mesenchymal stem cell exosomal METTL14 promotes AML cell growth and glycolysis by HOXA3/WNT7B axis [0.03%]
急性髓系白血病（AML）源性骨髓间充质干细胞外泌体METTL14通过HOXA3/WNT7B轴促进AML细胞增殖和糖酵解
Wanying Liu,Xi Ming,Jiaying Wu et al.
Wanying Liu et al.
Acute myeloid leukemia (AML)-derived bone mesenchymal stem cell (MSC) exosomes have been confirmed to have a positive effect on AML progression. This study aim to reveal the underlying molecular mechanism by which AML-MSC-derived exosomes p...