A novel tsRNA signature -tRF-58:76-Tyr-GTA-2-M3 as potential biomarker and therapeutic target for duodenal atresia [0.03%]
一种新的tsRNA签名-tRF-58:76-Tyr-GTA-2-M3作为十二指肠闭锁的潜在生物标志物和治疗靶点
Xinyue Meng,Xiaowei Wei,Hui Gu et al.
Xinyue Meng et al.
Duodenal atresia (DA) is a common neonatal digestive tract obstruction, with unclear prenatal diagnostic specificity and optimal intervention timing. tRNA-derived small RNAs (tsRNAs), stable and enriched in blood, are promising biomarkers f...
METTL3-mediated m⁶A methylation in cardiac diseases: pathogenic roles and therapeutic potential [0.03%]
METTL3介导的心肌m⁶A甲基化在心脏疾病中的致病作用及治疗潜力
Ruida Liu,Xiaojuan Su,Lei Yang et al.
Ruida Liu et al.
Cardiac dysfunction is a leading cause of death each year, putting heavy burdens on the global healthcare system. To improve our understanding of cardiac disease, novel perspectives for exploring their pathogenesis mechanisms are needed, wh...
Neuron-like macrophage differentiation via the APOE-TREM2 axis contributes to chronic pain in nasopharyngeal carcinoma [0.03%]
通过APOE-TREM2轴向神经元样巨噬细胞分化在鼻咽癌慢性痛发病机制中的作用研究
Hongxi Li,Lanqing Zhao,Jinwei Li et al.
Hongxi Li et al.
Chronic pain is a prevalent and debilitating symptom in patients with nasopharyngeal carcinoma (NPC). Fresh insights indicate that tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) may undergo neuron-like different...
IGFBP3 enhances adipose-derived stem cell function in soft tissue injury repair via ITGB1 and ERK pathway activation [0.03%]
胰岛素样生长因子结合蛋白3通过ITGB1和ERK途径激活促进脂肪源性干细胞在软组织损伤修复中的功能
Sirui Tian,Haiyang Yu,Ruoxuan Yang et al.
Sirui Tian et al.
Soft tissue injury (STI) is a prevalent condition that requires effective therapeutic approaches. The focus of this investigation was to elucidate the molecular mechanisms linked to the IGFBP3 protein in adipose-derived stem cells (ADSCs) f...
Activation of CaMKII+ neurons in the paramedian raphe nucleus promotes general anesthesia in male mice [0.03%]
旁中缝核CaMKII+神经元的激活通过促进机体进入全身麻醉状态调控小鼠睡眠
Xuehan Li,Zhixiong Ma,Xueliang Liu et al.
Xuehan Li et al.
General anesthesia (GA) is an essential clinical and surgical adjunct, widely recognized as the result of coordinated networks among numerous brain regions. Anesthetic drugs with different characteristics are associated with distinct networ...
Mitigating chemotherapy-induced granulosa cell damage: role of hUCMSC-EVs in regulating the lncRNA HCP5-miR-20a-5p-YAP1 network [0.03%]
化疗诱导的颗粒细胞损伤的防治：人脐带间充质干细胞外泌体调节lncRNA HCP5–miR-20a-5p–YAP1信号轴的作用
Ying Xie,Xiaoqin Chen,Tong Liang et al.
Ying Xie et al.
The substantial apprehension facing young cancer patients revolves around the onset of chemotherapy-induced premature ovarian failure (POF), primarily linked to damage inflicted upon granulosa cells (GCs). The inquiry delves into the protec...
Lactate-induced macrophage HMGB1 lactylation promotes neutrophil extracellular trap formation in sepsis-associated acute kidney injury [0.03%]
脓毒症相关急性肾损伤中乳酸诱导的巨噬细胞HMGB1乳酰化促进中性粒细胞胞外陷阱形成
Siwei Wei,Zijuan Dai,Lei Wu et al.
Siwei Wei et al.
Background: Neutrophils play a key role in sepsis-associated acute kidney injury (SAKI), a common and life-threatening complication of organ failure. High mobility group box 1 (HMGB1) modulates inflammatory responses and ...
Mechanism of lncRNA gadd7 regulating mitofusin 1 expression by recruiting LSD1 to down-regulate H3K9me3 level, and mediating mitophagy in alveolar type II epithelial cell apoptosis in hyperoxia-induced acute lung injury [0.03%]
长链非编码RNA gadd7通过募集LSD1下调H3K9三甲基化水平介导线粒体自噬在高氧诱导的急性肺损伤中促进Ⅱ型肺泡上皮细胞凋亡的作用机制研究
Guoyue Liu,Guiyang Jia,Yingcong Ren et al.
Guoyue Liu et al.
Objective: Hyperoxic exposure induces acute lung injury (ALI). We analyzed the mechanism of long non-coding RNA (lncRNA) growth-arrested DNA damage-inducible gene 7 (gadd7) regulating mitofusin 1 (MFN1) in Hyperoxia-induc...
Effects of the LINC00641/miR-323a-3p/EIF4G2 axis on behaviors and brain monoamine neurotransmitters in chronic unpredictable mild stress mice [0.03%]
LINC00641/miR-323a-3p/EIF4G2轴对慢性轻度不可预测应激小鼠行为及脑内单胺类神经递质的影响
Ziqiao Lin,Dong Qi,Yongbo Zhang
Ziqiao Lin
Objective: This paper aimed to probe the role of the LINC00641/miR-323a-3p/EIF4G2 axis in regulating behavioral and brain monoamine neurotransmitter levels in a mouse model of depression induced by chronic unpredictable m...
Jiaer Wang,Tao Yuan,Bo Yang et al.
Jiaer Wang et al.
Succinate dehydrogenase (SDH), considered as the linkage between tricarboxylic acid cycle (TCA cycle) and electron transport chain, plays a vital role in adenosine triphosphate (ATP) production and cell physiology. SDH deficiency is a notab...