Toxicogenomic Characterization of Perfluorooctanoic Acid-Associated Bladder Carcinogenesis [0.03%]
全氟辛酸相关膀胱致癌的毒基因组学特征分析
Yang Liu,Aifa Tang,Han Wang
Yang Liu
Objective: This study aims to bridge toxicological target prediction and bladder cancer transcriptomics by systematically identifying molecular signatures and pathways that converge between PFOA-associated toxicological e...
Brain organoids in environmental neurotoxicology: applications, mechanisms, and future perspectives [0.03%]
脑类器官在环境神经毒理学中的应用、机制及未来展望
Jiawen Liu,Yanling Xie,Meihui Zhu et al.
Jiawen Liu et al.
The advent of human induced pluripotent stem cell (hiPSC)-derived brain organoids represents a significant advance in environmental neurotoxicology, propelling the discipline toward human-relevant, mechanistic, and predictive in vitro parad...
Linc-ROR orchestrates autophagy suppression and marks gastric cancer via the miR-145-5p/CARMIL1 axis [0.03%]
长链非编码RNA Linc-ROR通过miR-145-5p/CARMIL1轴调控自噬抑制并作为胃癌标志物
Juan Ding,Rongshu Cui,Yunyan Teng et al.
Juan Ding et al.
Long non-coding RNAs (lncRNAs) have been considered the main regulators of cancer progression through their regulation of diverse cellular processes. Autophagy, which exerts context-dependent dual effects on gastric cancer (GC), remains con...
Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction [0.03%]
靶向ADAMTS1/HDAC6缓解心肌梗死后心脏纤维化中的TGF-β1/SMAD2相关心脏纤维化
Qiao Jin,Chun Chen,Pengcui Wu et al.
Qiao Jin et al.
Background: A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) is involved in the occurrence and development of myocardial fibrosis. Here, we sought to explore the specific regulatory mechanism of ...
Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle [0.03%]
镍纳米颗粒暴露下GC-1小鼠精原细胞中过载线粒体应激驱动的生殖损伤
Lu Kong,Geyu Liang,Yán Wāng
Lu Kong
Nickel nanoparticles (Ni NPs) are widely used in industrial and commercial sectors, raising concerns about their potential occupational and environmental toxicity. Male infertility has increased significantly in recent decades, with environ...
Inhibition of acalabrutinib metabolism by finerenone and its molecular docking studies [0.03%]
芬雷诺ン对阿卡拉布替尼代谢的抑制及其分子对接研究
Peiqi Wang,Haoxin Fu,Jun Wu et al.
Peiqi Wang et al.
Acalabrutinib is a frontline agent for chronic lymphocytic leukemia (CLL). The objective of this experiment was to screen 21 cardiovascular drugs with a focus on elucidating the metabolic inhibition of acalabrutinib by finerenone in vitro a...
Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells [0.03%]
单细胞RNA测序揭示败血症的转录异质性及SNHG5/miR-324-5p/CDK16轴在T细胞中表达下调
Jinxin Zhang,Heliang Fu,Shanshou Liu et al.
Jinxin Zhang et al.
Objective and design: T lymphopenia is a common phenomenon in the sepsis patients, closely related with secondary infection and patients death, whereas its mechanism is still largely unelucidated. Hence, it is urgent to s...
Zhangrong Xia,Xinmei Su,Lvsha Xie et al.
Zhangrong Xia et al.
Ferroptosis is a novel form of programmed cell death that is distinct from apoptosis, necrosis, and autophagy (macroautophagy). It is characterized by alterations in intracellular iron levels and lipid peroxidation. Considering its close as...
Mycotoxins, gut microbiota alterations and liver disease in animals: A scoping review [0.03%]
动物中的霉菌毒素、肠道微生物群变化和肝病：系统综述
Álvaro Lázaro,Massimo Frangiamone,Marcelo de Las Heras et al.
Álvaro Lázaro et al.
Mycotoxins are fungal secondary metabolites widely detected in up to eighty percent of frequently consumed foods, strongly associated with toxicological mechanisms. Evidence indicates that hepatic pathophysiology entails gut microbiota dysb...
Sublethal heat stress synergizes with the tumor microenvironment to drive recurrence of hepatocellular carcinoma after thermal ablation: mechanisms, molecular predictors, and targeted interventions [0.03%]
亚致死热应激与肿瘤微环境协同驱动热消融后肝细胞癌复发：机制、分子预测指标及靶向干预措施
Boran Li,Xiaoxi Bai,Liou Zhang
Boran Li
Although thermal ablation has emerged as a minimally invasive and effective local treatment for hepatocellular carcinoma (HCC), its high postoperative recurrence rate remains a major clinical challenge. Sublethal heat stress can induce resi...