Zijia Li,Yiwei Gu,Hui Gu et al.
Zijia Li et al.
Gastric cancer (GC) remains a major global health burden, and resistance to conventional therapies continues to limit durable clinical benefit. Increasing evidence identifies the N6-methyladenosine (m6A)-circular RNAs (circRNAs) axis as a c...
Unveiling a novel macrophage-driven mechanism for obeticholic acid-induced liver injury in cholestatic: targeting NLRP12Arg185 fuels Relb-TNFSF14-mediated ductular reaction [0.03%]
胆汁淤积时，新型的奥贝胆酸诱导的肝损伤的巨噬细胞驱动机制：靶向NLRP12Arg185介导Relb-TNFSF14激活的末导管反应
Jie Wang,Zihang Yuan,Haoran Zhang et al.
Jie Wang et al.
For individuals with Primary Biliary Cholangitis (PBC) who are either intolerant or nonresponsive to ursodeoxycholic acid (UDCA), obeticholic acid (OCA) is authorized as a therapeutic treatment. Nevertheless, its clinical application has be...
Meis1-driven suppression of MIF/CD74 signaling promotes M2 macrophage polarization and protects against inflammatory damage in experimental acute lung injury [0.03%]
Meis1通过抑制MIF/CD74信号促进M2型巨噬细胞极化并抵御实验性急性肺损伤中的炎症损伤
Gui Na Wang,Si Liu,Wei Xu
Gui Na Wang
Acute lung injury (ALI) is marked by dysregulated inflammatory responses, disruption of the alveolar-capillary barrier, and defective tissue repair, in which macrophages function both as drivers of tissue damage and facilitators of resoluti...
RNA m6A modification is a driver and therapeutic target in gastric cancer [0.03%]
胃癌中RNA m6A修饰是一种驱动因子和治疗靶点
Qingjuan Chen,Hongzhao Lu,Dezhi Li et al.
Qingjuan Chen et al.
N6-methyladenosine (m6A), the most abundant modification in eukaryotic RNAs, plays a critical role in regulating RNA stability, expression, and translation. Key m6A regulators are up- or down-regulated in human gastric cancer tissues, by He...
Xinxing Zhou,Zhongli Ge,Liu Tang et al.
Xinxing Zhou et al.
Gut microbiota (GM) serves several functions in host, including immunological modulation, maintaining intestinal epithelial cell barrier and defending against pathogen invasion. Previous research has demonstrated that GM could regulate dist...
Gomisin B promotes RSL3-induced ferroptosis in neuroblastoma by inhibiting the ESR1/USP7/SREBF1 axis [0.03%]
gomisin B通过抑制ESR1/USP7/SREBF1轴促进神经母细胞瘤中RSL3诱导的铁死亡
Mengyao Dong,Ting Gao,Yongtao Xu et al.
Mengyao Dong et al.
Background: Gomisin B was reported to alleviate neuroblastoma (NB) progression, and the promotion of ferroptosis also inhibited NB. This study aimed to investigate the mechanism by which Gomisin B regulates ESR1 to affect...
FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation [0.03%]
FBXO39敲低通过抑制KDM5A泛素化和调节H3K4me3去甲基化促进雄性不育及生精细胞铁死亡发生发展
Tao Li,Kun Wang,Yuxiang Chen et al.
Tao Li et al.
The global decline in male fertility highlights the need to understand the mechanisms of spermatogenesis. Mitochondrial dysfunction and ferroptosis have emerged as key contributors to spermatogenic impairment, although the molecular basis o...
Polystyrene Nanoplastics induced placental toxicology by activating Keap1-mediated ferroptosis via METTL3-dependent m6A methylation [0.03%]
聚苯乙烯纳米塑料通过METTL3依赖的m6A甲基化介导的Keap1途径激活诱导胎盘铁死亡毒性
Yujiao Chen,Yifan Liu,Meng Zhang et al.
Yujiao Chen et al.
Polystyrene nanoplastics (PS-NPs) exposure can induce placental toxicity, but the molecular mechanism of PS-NP-induced placental toxicity is poorly understood. We selected PS-NPs (80 nm) as a model of plastic particles and treated the human...
Lactate Dehydrogenase B delactylation promotes gastric cancer metastasis via enhancing glutathione-mediated resistance to ferroptosis [0.03%]
丙酮酸脱氢酶B去乳酸化通过增强谷胱甘肽介导的铁死亡抵抗促进胃癌转移
Xun Xiao,Yan Yang,Yunchao Yang et al.
Xun Xiao et al.
Purpose: To elucidate the role of protein lactylation in gastric adenocarcinoma progression, focusing on lactate dehydrogenase B (LDHB) delactylation at K58 and its effects on metastasis, glutathione (GSH) metabolism, and...
Chronic cadmium exposure promotes TRPM7-dependent acquisition of a myofibroblast-like phenotype in pancreatic stellate cells [0.03%]
慢性镉暴露通过TRPM7促进胰腺星状细胞获得肌成纤维母细胞样表型
Mathilde Fourgeaud,Julie Auwercx,Alexis Lalot et al.
Mathilde Fourgeaud et al.
Cadmium (Cd) is a metallic pollutant which has been classified as a possible pancreatic carcinogen. Cd uses similar ion channels than divalent cations to accumulate into the cells. These include the Transient Receptor Potential Cation Chann...