Rui Yang,Rongping Chen,Ningning Xu et al.
Rui Yang et al.
Background: As a primary contributor to end-stage renal disease, diabetic kidney disease (DKD) is characterized by metabolic and inflammatory disturbances. Emerging evidence highlights the gut microbiota's contribution to...
ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling [0.03%]
ADT通过改变AR/SALL4/SOX2-OCT4干细胞信号增加前列腺癌细胞侵袭性
Changcheng Guo,Aimaitiaji Kadier,Zhijin Zhang et al.
Changcheng Guo et al.
Early studies indicated that the androgen-deprivation-therapy with antiandrogen Enzalutamide (Enz) could increase prostate cancer patients' survival by an average of 4.8 months. Yet Enz might also have some adverse effects via increasing th...
Single-cell spatial proteomics of non-relapse small cell lung cancer identifies tumor microenvironment determinants of survival [0.03%]
单细胞空间蛋白质组学识别非小细胞肺癌预后标志物
Yin Li,Liliang Xia,Hui Wang et al.
Yin Li et al.
Small cell lung cancer (SCLC) is characterized by high malignancy and early propensity for metastasis, and modest response to immunotherapy due to the immunosuppressive microenvironment. Surgical intervention has shown benefits in treating ...
The role of lncRNA HUPCOS in androgen metabolism and follicle growth arrest in polycystic ovary syndrome [0.03%]
长链非编码RNA HUPCOS在多囊卵巢综合征雄激素代谢及卵泡生长阻滞中的作用研究
Jun Xie,Xiao Xu,Yuning Chen et al.
Jun Xie et al.
Background: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and follicular growth arrest. This study investigates the role of a newly identified long non-coding RNA, lncRNA-ZSCAN2-5:15 (HUPCOS), in t...
From neurotoxicity to neuroprotection: Rethinking GABAAR-targeting anesthetics [0.03%]
从神经毒理到神经保护：再思考作用于GABA受体的麻醉药
Yubao Li,Hongliang Yang,Lu Liu et al.
Yubao Li et al.
The brain growth spurt (BGS) represents a pivotal window in neurodevelopment, defined by rapid neurogenesis, heightened synaptogenesis, and the dynamic establishment of neural networks. During this phase, heightened brain plasticity signifi...
GelMA hydrogel-loaded extracellular vesicles derived from keratinocytes promote skin microvasculature regeneration and wound healing in diabetic mice through activation of the PDGF-induced PI3K/AKT pathway [0.03%]
角质细胞源性外泌体凝胶化明胶水凝胶通过活化PDGF-PI3K/AKT通路促进糖尿病小鼠皮肤微血管再生和伤口愈合
Qian Li,Leilei Zhou,Wenqiang Li et al.
Qian Li et al.
Objective: This study explores how extracellular vesicles (EVs) derived from keratinocytes cultured in Gelatin Methacryloyl (GelMA) hydrogels facilitate microvascular regeneration and enhance wound repair in diabetic skin...
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance [0.03%]
胃癌中NFATC2/SERPINE1/JAK3/STAT3信号反馈回路与免疫逃逸和抗PD-1耐药性关系的研究
Zhenyu Yang,Dingwen Zhong,Xi&#x;e Hu et al.
Zhenyu Yang et al.
Objectives: This research investigates how the SERPINE1-associated tumor microenvironment influences anti-PD-1 treatment response in gastric carcinoma (GC). ...
Oral squamous cell carcinoma: Insights into cellular heterogeneity, drug resistance, and evolutionary trajectories [0.03%]
口腔鳞状细胞癌：关于细胞异质性、药物耐受性和进化轨迹的见解
Yang Zhou,Liyin Wang,Minghua Liu et al.
Yang Zhou et al.
Oral squamous cell carcinoma (OSCC) can lead to metastasis and high mortality rates known for its aggressive and invasive properties. Currently, primary treatment options of surgical resection, chemotherapy and radiotherapy have many therap...
Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis [0.03%]
METTL3/STC2在结直肠癌中的调控机制及其介导的药物耐受和转移的功能研究
Qiang Su,Kaiyue Wang,Ruohan Liao et al.
Qiang Su et al.
In recent years, the role of epigenetic modifications, especially N6-methyladenosine (m6A) modifications, in the occurrence and development of cancer has received increasing attention. This study aims to elucidate the role of m6A modificati...
SENP3 alleviates osteoporosis via promoting SIRT3 transcription through the increase of DLX2 stability via SUMO2/3 [0.03%]
SENP3通过增加SUMO2/3依赖的DLX2稳定性促进SIRT3转录从而缓解骨质疏松症
Jie Bu,Xuezheng Xu,Yi Luo et al.
Jie Bu et al.
Background: Recent studies have indicated a close relationship between SENP3 and osteoporosis. However, the detailed molecular mechanism of SENP3 mediating osteoporosis has not been well studied. The goal of this work was...