ZMIZ1 lactylation induces tamoxifen resistance in breast cancer through increasing transcriptional activity of Nanog to impact cell stemness and cholesterol uptake [0.03%]
ZMIZ1 琥珀酰化通过增加 Nanog 的转录活性诱导乳腺癌细胞耐药性并影响干细胞特性及胆固醇摄取
Yue Liu,Jingyu Chen,Li Ma et al.
Yue Liu et al.
Tamoxifen is a critical drug for the treatment of oestrogen receptor (ER)-positive breast cancer (BC), which represents the majority of BC subtypes. However, many BC tumours that initially respond eventually develop acquired Tamoxifen resis...
The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1 [0.03%]
SDF-1α/MTDH轴通过促进SREBP1核转位来抑制铁死亡并促进抗VEGF耐药性脉络膜新生血管形成
Rong Zou,Xi Zhang,Xiaochan Dai et al.
Rong Zou et al.
Age-related macular degeneration (AMD) has been well recognized as the first ranked blinding ocular fundus diseases among older individuals, particularly in developed regions, owing to its progressive nature and high prevalence in aging pop...
Epi-nutrients for cancer prevention: Molecular mechanisms and emerging insights [0.03%]
癌症预防的营养素：分子机制和新兴观点
Saad Bakrim,Nasreddine El Omari,Ouadie Mohamed El Yaagoubi et al.
Saad Bakrim et al.
The burgeoning field of epigenetics holds considerable potential in cancer prevention and management, as it targets mechanisms essential to regulating gene expression without altering DNA sequences. Epigenetic processes like DNA methylation...
Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers [0.03%]
用于妇科肿瘤药物输送和组织工程的混合水凝胶设计的新进展：在生物医学应用中的创新
Hua Chang,Heng Wei,Yue Qi et al.
Hua Chang et al.
Hybrid hydrogels have emerged as multifunctional biomaterials for targeted drug delivery and tissue engineering in gynecologic oncology. In this review, we summarize recent advances in the design of hybrid hydrogels that combine polymer net...
Single-nucleus rna sequencing identifies universal camk1d upregulation and dysregulated c-ltmr subtypes as key drivers of paclitaxel-induced neuropathy [0.03%]
单核RNA测序揭示CaMK1D上调和紫杉醇诱导的外周神经病变中失调的感觉神经元亚型
Wuping Sun,Rongzhen Li,Xinyi Zhang et al.
Wuping Sun et al.
Neuropathic pain triggered by chemotherapy poses a significant clinical challenge. Investigating cell type-specific alterations through single-cell transcriptome analysis holds promise in understanding symptom development and pathogenesis. ...
cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction [0.03%]
cGAS-STING通路具有治疗脓毒症相关器官功能障碍的潜力
Tao Yu,Joshua S Fleishman,Hongquan Wang et al.
Tao Yu et al.
Sepsis is clinically defined as a life-threatening syndrome characterized by dysregulated host responses to infection, culminating in progressive multi-organ dysfunction. The pathogenesis of sepsis-associated organ dysfunction (SAOD) -manif...
KMT2D/ZNF460-induced COL9A1-mediated extracellular matrix stiffness maintains the cancer stem cell pool to promote colorectal cancer progression [0.03%]
KMT2D/ZNF460通过诱导COL9A1介导的细胞外基质刚性维持癌症干细胞池促进结直肠癌进展
Chengxin Song,Jingmin Xue,Wenjie Song et al.
Chengxin Song et al.
Collagen is a central component of the extracellular matrix (ECM) in tissues, and ECM can promote tumor cell immune evasion. Our research aimed to expound the biological function of the collagen alpha-1(IX) chain (COL9A1) in colorectal canc...
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through m6A-dependent binding [0.03%]
YTHDF1通过m６A依赖性结合促进p53翻译并在急性脑缺血/再灌注期间诱导铁死亡
Xinyu Chang,Bingwu Li,Wanxu Huang et al.
Xinyu Chang et al.
The rapid escalation of oxidative and nitrosative stress during ischemia/reperfusion (I/R) triggers neuronal damage, leading to severe neurological deficits and long-term disability. N6-methyladenosine (m6A), a highly abundant RNA modificat...
TEAD4-mediated upregulation of LPAR3 augments hepatic stellate cell activation in portal hypertension [0.03%]
TEAD4介导的LPAR3上调促进门脉高压性肝星状细胞活化
Ruizhao Qi,Zhengyao Chang,Wenlei Zhao et al.
Ruizhao Qi et al.
Based on bioinformatics insights, this study investigates the functions of lysophosphatidic acid receptor 3 (LPAR3) and TEA domain transcription factor 4 (TEAD4) in hepatic stellate cell (HSC) activation and portal hypertension (PHT) progre...
NGR-modified curcumin nanovesicles reverse immunotherapy resistance in triple-negative breast cancer via TLR9 and mTOR pathway modulation [0.03%]
NGR修饰的姜黄素纳米囊泡通过TLR9和mTOR途径调节逆转三阴性乳腺癌的免疫疗法耐药性
Shuo Wang,Xiaoou Wang,Xinyu Zheng et al.
Shuo Wang et al.
Curcumin (Cur), a natural bioactive compound extracted from Curcuma longa, has garnered extensive interest due to its modulation of inflammation, antioxidant, and anti-tumor properties. However, its therapeutic translation remains constrain...