Mechanism of uptake and toxicity of a BCMA antibody drug conjugate with a MMAF payload by nonantigen expressing cells [0.03%]
不表达抗原的细胞摄取和BCMA抗体偶联药物（载荷为MMAF）毒性的机制研究
Carla Newman,Chloe Taylor,Gurpreet Sohanpal et al.
Carla Newman et al.
Belantamab mafodotin, an antibody-drug conjugate (ADC), has shown strong efficacy in multiple myeloma. It comprises a humanized anti-B-cell maturation antigen (BCMA) IgG1 monoclonal antibody conjugated to the microtubule inhibitor monomethy...
ZRANB1 depletion inhibits neuroblastoma progression by destabilizing MYCN through EZH2-mediated deubiquitination [0.03%]
ZRANB1通过EZH2介导的去泛素化稳定MYCN促进神经母细胞瘤进展
Zhichao Wang,Long Cheng,Guanghui Li et al.
Zhichao Wang et al.
Background: Neuroblastoma (NB) is a common malignant solid tumor in children, notably aggressive in cases with MYCN amplification. Unraveling the mechanisms behind NB progression is crucial for developing targeted therapi...
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke [0.03%]
多组学分析和实验验证揭示IRF7-CXCL10轴是缺血性卒中微胶质细胞程序性坏死的主要调节因子
Yongxing Lai,Peiqiang Lin,Kexin Zhang et al.
Yongxing Lai et al.
Background: Microglia-driven neuroinflammation serves as a critical factor in secondary injury following ischemic stroke, yet the primary regulators governing detrimental microglial phenotypes remain unclear. As a key com...
Aixin Wang,Xinyu Ye,Yumeng Zhao et al.
Aixin Wang et al.
Mitochondria, as key organelles in eukaryotic cells, regulate cellular energy homeostasis and functional integrity through dynamic processes, including fission, fusion, autophagy, and transport, underpinned by precise molecular mechanisms. ...
The PRKN/METTL3/CLDN2 axis promotes colorectal cancer development through epigenetic mechanisms [0.03%]
PRKN/METTL3/CLDN2轴通过表观遗传机制促进结直肠癌发生发展
Hongtao Ren,Mincong Wang,Xiulong Ma et al.
Hongtao Ren et al.
Background: Dysregulation of N6-methyladenosine (m6A) RNA methylation plays a crucial role in colorectal cancer (CRC) development. Despite the established oncogenic role of methyltransferase-like 3 (METTL3) in CRC, the me...
N-nitrosodimethylamine induces cytochrome P450 activation but not epithelial remodeling in well-differentiated human airway epithelial cells [0.03%]
N-亚硝基二甲胺诱导了人呼吸道上皮细胞中细胞色素P450的活化，但并未导致上皮重塑在分化良好的人类呼吸道上皮细胞中
Faria Khan,Megan E Solan,Hyo Jin Kim et al.
Faria Khan et al.
N-nitrosodimethylamine (NDMA) is a volatile environmental contaminant formed from diverse precursor chemicals widely present in byproducts of industrial processes, personal care products, and pharmaceuticals. Therefore, NDMA is frequently d...
ALKBH5/IGF2BP1-mediated m6A demethylation of TRIM37 promotes pancreatic cancer tumorigenesis and glycolysis by mediating RBMX degradation [0.03%]
通过介导RBMX降解促进胰腺癌发生和糖酵化的ALKBH5 / IGF2BP1介导的TRIM37去甲基化
Cheng Yan,Xuan Li,Ying Zhao et al.
Cheng Yan et al.
Background: The upregulation of the ubiquitin ligase TRIM37 is associated with an adverse prognosis in pancreatic ductal adenocarcinoma (PDAC). This study investigates the mechanism and oncogenic consequence of TRIM37 upr...
NFE2L2 suppresses microglia-mediated neuroinflammation to preserve neuronal dendritic architecture from cadmium-induced damage [0.03%]
NFE2L2通过抑制小胶质细胞介导的神经炎症来保护镉诱导损伤中的神经元树突结构
Siyao Li,Xue Wang,Xiaolong Ma et al.
Siyao Li et al.
Cadmium (Cd), a widespread environmental toxic metal, is linked to central nervous system dysfunction and neuronal structural damage, yet its mechanisms remain unclear. This study combined network toxicology with experimental validation to ...
Regulation of m6A modifications in Th2-driven allergic responses: impact on responses and therapeutic potential [0.03%]
过敏性免疫反应中m6A修饰的调控及其功能和治疗潜能研究
Meng Wang,Yunxiu Wang,Zhiwei Cao et al.
Meng Wang et al.
Th2-driven allergic responses are characterized by allergic reactions and immune dysregulation with complex pathogenesis that warrants urgent in-depth study. The predominant posttranscriptional modification observed in eukaryotic messenger ...
Macrophage exosomal ADAM10 mediates alveolar epithelial apoptosis induced by wood smoke PM2.5 [0.03%]
木烟PM2.5通过巨噬细胞外泌体ADAM10介导肺泡上皮细胞凋亡
Na Zhan,Yufeng Wang,Ru Liang et al.
Na Zhan et al.
Wood smoke (WS)-derived PM2.5 is a major environmental risk factor for emphysema, but the role of macrophage-derived exosomes remains unclear. Here, we show that chronic WS exposure in rats induces emphysematous lesions accompanied by marke...