DNMT1 recruits RUNX1 and represses FOXO1 transcription to inhibit anti-inflammatory activity of regulatory T cells and augments sepsis-induced lung injury [0.03%]
DNMT1募集RUNX1并抑制FOXO1转录以抑制调节性T细胞的抗炎活性并加剧脓毒症诱导的肺损伤
Jurong Ding,Benyong Xu,Mingyan Wu et al.
Jurong Ding et al.
Sepsis-induced lung injury (ALI) is a critical condition characterized by excessive immune responses and tissue damage. Previous evidence has underscored an upregulation pattern of DNA methyltransferase 1 (DNMT1) in sepsis. This study revea...
Correction to: LINC00858 promotes colorectal cancer by sponging miR-4766-5p to regulate PAK2 [0.03%]
Correction to: LINC00858通过海绵作用于miR-4766-5p来调节PAK2从而促进结直肠癌
Wei Zhan,Xin Liao,Zhongsheng Chen et al.
Wei Zhan et al.
Published Erratum
Cell biology and toxicology. 2025 Aug 25;41(1):127. DOI:10.1007/s10565-025-10077-9 2025
USP18 promotes ferroptosis in lipopolysaccharide-induced human kidney organoids by stabilizing STING1 [0.03%]
USP18通过稳定STING1促进脂多糖诱导的人类肾脏器官oid的铁死亡
Hao Yang,Lingfei Zhao,Weiwei Kong et al.
Hao Yang et al.
Sepsis-induced acute kidney injury (SI-AKI) is a severe condition with limited therapeutic options, resulting in poor prognosis. Ferroptosis exacerbates the damage caused by SI-AKI, but the mechanisms regulating ferroptosis, especially thos...
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA [0.03%]
NAT10通过对TGFBR1 mRNA进行ac4C修饰介导心肌梗死诱导的心脏纤维化
Jiamin Zhou,Yu Chen,Jinfa Chen et al.
Jiamin Zhou et al.
Cardiac fibrosis is a critical pathological process following myocardial infarction (MI), contributing to adverse cardiac remodeling and dysfunction. This study investigates the role of N-acetyltransferase 10 (NAT10), an RNA acetyltransfera...
METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of m7G- 3' tiRNA MetCAT [0.03%]
METTL1通过增强G3BP1的翻译和m7G-3'tiRNA MetCAT的表达促进镉诱导的应激颗粒形成
Wenyu Hu,Yaomin Liang,Xiaoling Ying et al.
Wenyu Hu et al.
Methyltransferase 1 (METTL1) is currently regarded as a key tRNA m7G writer. Recent studies indicate its potential role in carcinogenesis via increased m7G modification to stabilize tRNA and upregulate tRNA expression. Cadmium-induced stres...
FTO-mediated the destabilization of RASGRF1 mRNA impedes thyroid cancer progression and suppresses macrophage M2 polarization [0.03%]
FTO介导的RASGRF1 mRNA不稳定性抑制甲状腺癌进展并抑制巨噬细胞M2极化
Zongyu Li,Jiancang Ma,Hao Guan et al.
Zongyu Li et al.
Background: The guanine nucleotide exchange factor RASGRF1 actively acts in a broad range of human cancers, including thyroid cancer (THCA). This study defined the activity of RASGRF1 in THCA progression and elucidated th...
CD44-targeted therapy using mP6/Rg3 micelles inhibits oral cancer stem cell proliferation and migration [0.03%]
针对口腔癌干细胞增殖和迁移的CD44靶向mP6/Rg3介导治疗
Sijia Cai,Yuwen Chen,Changyu Chen et al.
Sijia Cai et al.
Background: This study investigates how mP6/Rg3 micelles modulate ABCB1 expression to induce ferroptosis in oral cancer stem cells (CSC) and enhance oral cancer outcomes. ...
Targeting PTK2 by vaccarin alleviates osteoporosis through inhibiting ferroptosis via modulating P53 acetylation/succinylation [0.03%]
黄花草乌梅素通过调节P53乙酰化/琥珀化抑制铁死亡来缓解骨质疏松症：靶向PTK2
Yanna Wang,Changyuan Wang,Ying Gong et al.
Yanna Wang et al.
Osteoporosis (OP) is a systemic skeletal disorder marked by reduced bone density and deterioration of trabecular microstructure. Recent studies have established ferroptosis as a major contributor to osteoporotic bone loss; however, the spec...
Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway [0.03%]
asperosaponin VI通过调节AMPK-SIRT3信号通路缓解骨关节炎的线粒体功能障碍和软骨细胞凋亡
Jie Qiao,Ruibing Feng,Gongxu Yang et al.
Jie Qiao et al.
Objective: To investigate the therapeutic potential of Asperosaponin VI (ASA VI) from Clematis chinensis in mitigating osteoarthritis (OA) progression by modulating the AMPK-SIRT3 pathway, specifically addressing ER stres...
Intersection of ferroptosis and nanomaterials brings benefits to breast cancer [0.03%]
铁死亡与纳米材料的结合在乳腺癌治疗中的应用益处
Jian Gao,Ningye Ma,Sha Ni et al.
Jian Gao et al.
Breast cancer (BC) is the most frequently diagnosed malignancy among women worldwide, with a high incidence and mortality rate. Despite advances in treatment, approximately 10%-15% of patients with BC still face recurrence. Therefore, impro...