Multiple sevoflurane exposures in early development lead to long-term vascular abnormalities in the hippocampus [0.03%]
发育早期多次暴露于异氟醚可导致海马血管长期异常
Yu Matsumoto,Kazue Hashimoto-Torii,Masaaki Torii
Yu Matsumoto
Children who undergo multiple exposures to anesthesia for surgeries and procedures are at increased risk of developing neurocognitive impairments. Growing evidence suggests that anesthesia-induced neurotoxicity and acute damage to neural ce...
The HDAC1 inhibitor attenuates renal ischemia-reperfusion injury via dual epigenetic modulation of p53 and macrophage NF-κB pathways [0.03%]
HDAC1抑制剂通过表观遗传学调节p53和巨噬细胞NF-κB通路双机制缓解肾脏缺血再灌注损伤
Qian-Qian Zhang,Chen-Zhen Yu,Fei-Hong Yu et al.
Qian-Qian Zhang et al.
Background: The renal regenerative capacity hinges on tubular epithelial cell (TEC) plasticity, while Macrophage activation and their crosstalk with tubular cells further drive ischemia-reperfusion injury (IRI) progressio...
The role of e3 ubiquitin ligases and deubiquitinating enzymes in hepatocellular carcinoma [0.03%]
E3泛素连接酶和去泛素化酶在肝细胞癌中的作用
Lei Wang,Hongyan Zhang,Yue Hu et al.
Lei Wang et al.
Ubiquitination, a key post-translational modification, is responsible for regulating protein stability, activity, subcellular localization, and interactions via the ubiquitin-proteasome system (UPS). The UPS plays a role in non-lysosomal pr...
Troxerutin suppresses the stemness of hepatocellular carcinoma via the Syk/FOXO3 feedback loop [0.03%]
芸香苷通过Syk/FOXO3反馈回路抑制肝癌干细胞特性
Shan Liu,Yuan Lin,Huan Xia et al.
Shan Liu et al.
Hepatocellular carcinoma (HCC) remains one of the deadliest malignancies worldwide due to its high rates of recurrence and metastasis. This underscores the urgent need to develop innovative drugs and treatment strategies to improve patient ...
Roles of gut and oral microbiota in methamphetamine-induced multi-organ toxicity [0.03%]
肠道和口腔菌群在甲基苯丙胺诱导的多器官毒性中的作用
Jiebin Rong,Jingshen Zhuang,Jialong Xu et al.
Jiebin Rong et al.
Methamphetamine (METH) is an illicit stimulant that is in widespread use worldwide. Repeated intake of METH can lead to addiction and multiple-organ damage, which has become a globalized problem. However, the mechanism of METH toxicity rema...
SPSB3-mediated K48- and K63- linked ubiquitination and degradation of TUFM promote apoptosis induced by myocardial ischemia/reperfusion injury [0.03%]
PSDB3介导的TUFMK48-和K63-多聚泛素化及其降解促进心肌缺血再灌注损伤诱导的细胞凋亡
Yuyao Yin,Yaofeng Xie,Xiao Wang et al.
Yuyao Yin et al.
Hypoxia, caused by various factors, significantly threatens human health by damaging the heart and cardiomyocytes. Revascularization strategies can sometimes precipitate adverse clinical outcomes due to myocardial ischemia/reperfusion (I/R)...
Subthalamic CaMKIIα-expressing neurons facilitate recovery from propofol anesthesia via the STN-ventral pallidum pathway [0.03%]
钙调神经磷酸酶 α 表达的亚thalamic 核元通过丘脑底核-腹侧被盖体通路促进异丙酚麻醉复苏
Shangqin Bai,Yiqiu Chen,Yu Li et al.
Shangqin Bai et al.
Propofol is extensively used in clinical anesthesia, yet its mechanisms of action remain incompletely understood. CaMKIIα-expressing neurons in the subthalamic nucleus (STN) have been associated with arousal-related pain perception and imp...
DNAJB4/HLJ1 protects against acetaminophen-induced liver injury by attenuating ER stress via HSP70 [0.03%]
DNAJB4/HLJ1通过HSP70抑制内质网应激从而保护肝脏免受对乙酰氨基酚引起的肝损伤
Chih-Yun Lu,Tsung-Hsuan Hsieh,Min-Hui Chien et al.
Chih-Yun Lu et al.
Drug-induced liver injury (DILI) remains a leading cause of acute liver failure; however, current clinical strategies lack reliable biomarkers, predictors of susceptibility, and effective therapeutic interventions. Among these etiologies, a...
METTL14 modulates the autophagy-pyroptosis pathway in fibroblasts by modifying BECN1 through m6A methylation to promote wound healing in DFUs and SYD treatment [0.03%]
METTL14通过m6A甲基化修饰BECN1调节成纤维细胞的自噬-焦亡途径促进DFU和SYD伤口愈合
Zhaowei Wang,Zongqiang Wei,Qinyao Yu et al.
Zhaowei Wang et al.
Background: Diabetic foot ulcers (DFUs) are prevalent complication in diabetes. METTL14 serves as a key regulator of both autophagy and pyroptosis, both essential for the healing of DFUs. Simiao Yong'an Decoction (SYD) ha...
TCF12-mediated transcriptional activation of CCDC34 is involved in the positive feedback of tumor-associated macrophages and EMT to promote LUSC [0.03%]
TCF12介导的CCDC34转录激活参与肿瘤相关巨噬细胞和上皮间质转化促进肺鳞癌正反馈回路
Jieli Yu,Qinyuan Zhan
Jieli Yu
The positive feedback loop between epithelial-mesenchymal transition (EMT) and M2-like tumor-associated macrophages (TAM-M2) contributes to tumor growth and metastasis. This research aims to investigate the regulatory mechanism of CCDC34 in...