m6A-mediated silencing of RNF41 by METTL3/YTHDC1 disrupts autophagy to drive intervertebral disc degeneration [0.03%]
METTL3/YTHDC1介导的RNF41 m6A甲基化沉默通过破坏自噬促进椎间盘退变
Bo Yao,Li Wan,Jia Deng et al.
Bo Yao et al.
Background: Intervertebral disc (IVD) degeneration (IDD) represents a predominant origin of low back pain and disability, yet current therapeutic interventions remain suboptimal. Emerging evidence highlights autophagy act...
Correction to: Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development [0.03%]
Correction to： Celastrol通过调节IRS1表达改善卵巢早衰和促进卵泡发育
Yao Jiang,Yonghua Shi,Meng Lv et al.
Yao Jiang et al.
Published Erratum
Cell biology and toxicology. 2025 Nov 3;41(1):148. DOI:10.1007/s10565-025-10107-6 2025
HypoxamiRs in pancreatic cancer: master regulators of the hypoxic tumor microenvironment [0.03%]
胰腺癌中的缺氧miRNA：缺氧性肿瘤微环境的调控因子
Pooria Salehi-Sangani,Amir Hosein Maharati,Bahareh Payami et al.
Pooria Salehi-Sangani et al.
Pancreatic cancer (PC) is characterized by aggressive progression, chemoresistance, and immune evasion, largely driven by its hypoxic tumor microenvironment (TME). The extensive desmoplastic reaction in PC, characterized by dense stromal fi...
Strand-specific functions of miR-301a-3p and -5p drive opposing roles in pancreatic cancer via ferroptosis and pyroptosis [0.03%]
miR-301a-3p和-5p的链特异性功能通过铁死亡和焦亡在胰腺癌中发挥相反作用
Yuhang Chen,Suoyi Dai,Wenxun Cai et al.
Yuhang Chen et al.
Pancreatic ductal adenocarcinoma is among the most lethal malignancies, underscoring the urgent need for a deepened molecular insights and targeted strategies. While microRNAs (miRNAs) are known to regulate key oncogenic pathways in PDAC, m...
Ferroptosis: molecular mechanisms, pathophysiology, and role in pediatric pulmonary diseases [0.03%]
铁死亡的分子机制、病理生理学及其在儿童肺部疾病中的作用
Junjie Ning,Lina Qiao
Junjie Ning
Ferroptosis is a distinct form of programmed cell death characterized by iron-dependent oxidative stress and the accumulation of intracellular reactive oxygen species. This process involves multiple structural alterations, such as rupture o...
ATG5-dependent autophagy in Sertoli cells protects against cadmium-disrupted blood-testis barrier via perturbing CXCL2/CXCR2 axis [0.03%]
ATG5依赖的Sertoli细胞自噬通过干扰CXCL2/CXCR2轴保护镉破坏的血睾屏障
Hao Li,Yi-Fan Hu,Xin-Run Wang et al.
Hao Li et al.
The blood-testis barrier (BTB), a unique structure established through intercellular connections of Sertoli cells, establishes a protective microenvironment for spermatogenesis and male fertility. Cadmium (Cd), known for its toxicity, is ub...
SerpinB1a induces hepatopulmonary syndrome by promoting CTSG/AMPK/mTOR pathway-mediated mitophagy [0.03%]
SERPINB1A通过促进CTSG/AMPK/mTOR通路介导的线粒体自噬诱导肝肺综合征
Liang Li,Jianzhong Li,Wendeng Li et al.
Liang Li et al.
Mitophagy, as an important mechanism for selective removal of damaged mitochondria in cells, plays a crucial role in upholding cellular homeostasis. Mounting evidence suggests that autophagy is associated with lung disease. However, the pot...
ETV4 promotes ovarian cancer growth by regulating mitochondrial function through Mfn2 ubiquitination mediated by the E3 ubiquitin ligase MARCH9 [0.03%]
ETV4通过E3泛素连接酶MARCH9介导的线粒体动力蛋白Mfn2泛素化调节线粒体功能促进卵巢癌生长
Ying Wang,Zhan Wang,Juan Chen et al.
Ying Wang et al.
Background: Mitochondrial dysfunction affects the development of ovarian cancer (OC). ETV4 is involved in mitochondrial fusion. The regulatory pathways of ETV4 in OC cells have not been further investigated. In this study...
PARP1 contributes to intimal hyperplasia by regulating METTL3-mediated m6A methylation of TRAIL [0.03%]
PARP1通过调控METTL3介导的TRAILm6A甲基化参与内膜增生
Shaodong Li,Fengxiang Pang,Wenhai Guo et al.
Shaodong Li et al.
Poly (ADP-ribose) polymerase 1 (PARP1) promotes vascular intimal hyperplasia (IH) while contributing to N6-methyladenosine (m6A) methylation regulatory processes. The present study focuses on whether the PARP1 inhibitor PJ34 can improve vas...
Ginsenoside Rh2 targets SIRT1-mediated deacetylation to modulate ERα/AR balance and overcome endocrine therapy resistance in prostate cancer using 3D organoid models [0.03%]
Ginsenoside Rh2通过靶向SIRT1介导的去乙酰化作用来调节ERα/AR平衡并克服前列腺癌内分泌治疗耐药性的研究（使用三维类器官模型）
Xinan Chen,Wei Luo,Yueying Ren et al.
Xinan Chen et al.
Resistance to endocrine therapy remains a major challenge in treating prostate cancer (PCa), highlighting the need for alternative therapeutic approaches. In this study, we investigated the potential of Ginsenoside Rh2 to counteract such re...