EZH2/DUSP1/Akt signaling axis mediates the inhibitory effect of crebanine on hepatocellular carcinoma progression [0.03%]
CREBAIN通过EZH2/DUSP1/Akt信号轴抑制肝癌进展
Jinxia Qi,Zhikai Wen,Yanju Ren et al.
Jinxia Qi et al.
Hepatocellular carcinoma (HCC) is characterized by a subtle onset, rapid development, and high malignancy. Traditional treatments have struggled to cure patients with advanced HCC. Crebanine is an isoquinoline aporphine alkaloid extracted f...
Integrative multi-omics, machine learning, and experimental validation reveal that TPM1 suppresses M2 macrophage polarization and enhances chemosensitivity in acute myeloid leukemia [0.03%]
整合多组学、机器学习和实验验证揭示TPM1在急性髓系白血病中可抑制M2型巨噬细胞极化并增强化疗敏感性
Yue Li,Baosheng Wei,Liuping Hu et al.
Yue Li et al.
Background: Acute myeloid leukemia (AML) remains a therapeutic challenge due to chemoresistance and immunosuppression. This study aimed to discover novel regulatory mechanisms in AML pathogenesis. ...
Integrated lipidome and miRNome analyses reveal sex-based differences in circulating extracellular vesicles of alcohol use disorder patients [0.03%]
整合脂质组和miRNome分析揭示酒精使用障碍患者的性别差异性循环细胞外囊泡特性
Carla Perpiñá-Clérigues,Susana Mellado,Cristina Galiana-Roselló et al.
Carla Perpiñá-Clérigues et al.
Integrated multi-omics and extracellular vesicle (EV) analysis are emerging as powerful, complementary strategies for biomarker discovery. These approaches offer promising tools to enhance early detection, diagnosis, and treatment of alcoho...
ALKBH5-mediated m6A demethylation of PRMT6 inhibits neuronal apoptosis and ferroptosis in Alzheimer's disease via reducing transcription of ACSL4 [0.03%]
ALKBH5通过降低ACSL4转录抑制阿尔茨海默病中的神经元凋亡和铁死亡的机制研究
Jingwei Cao,Haining Wang,Baichao Han et al.
Jingwei Cao et al.
Background: Protein arginine methyltransferase 6 (PRMT6) is confirmed to regulate Alzheimer's disease (AD) process. Acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis is involved in regulating AD ...
SIRT5-mediated HSDL2 desuccinylation promotes diabetic-associated cognitive dysfunction via disrupting mitochondrial TRAP1 [0.03%]
SIRT5介导的HSDL2脱琥珀酰化通过破坏线粒体TRAP1促进糖尿病相关的认知功能障碍
Yinmeng Qu,Renjie Liu,Xuan Chen et al.
Yinmeng Qu et al.
Diabetic-associated cognitive dysfunction (DACD) is a severe complication of diabetes characterized by mitochondrial failure in hippocampal neurons, yet its precise molecular drivers remain poorly understood. Here, hydroxysteroid dehydrogen...
Decoding shared pathogenic networks of oxidative stress in neuropsychiatric disorders to prioritize multi-target therapeutics from natural products [0.03%]
解析神经精神疾病中氧化应激的共同致病网络以优先选择天然产物中的多靶标药物
Xuan Xu,Zhu Ni,Yan-Bin Wang et al.
Xuan Xu et al.
Background: Neurodegenerative and psychiatric disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and schizophrenia (SZ), are characterized by progressive neuronal loss and ...
ARF6 promotes the nuclear translocation of β-catenin to facilitate AFP deficiency-mediated metastasis in CTNNB1S33Y-mutant hepatocellular carcinoma [0.03%]
ARF6促进CTNNB1S33Y突变肝癌中AFP缺乏介导的转移所需的β-catenin核转位
Ruitian Zhang,Longxuan Dong,Junyi Yang et al.
Ruitian Zhang et al.
The mortality rate associated with hepatocellular carcinoma (HCC) remains alarmingly high, positioning it as a primary lethal cancer worldwide, primarily driven by its high degree of malignancy, recurrence, and metastasis. The high heteroge...
Mechanisms of TRIM21-mediated RUNX2 degradation via chaperone-mediated autophagy in periodontitis [0.03%]
TRIM21通过分子伴侣介导的自噬降解RUNX2在牙周炎中的机制研究
Yi Zhao,Yuyu Ge,Qiaoli Zhai et al.
Yi Zhao et al.
The osteogenic capability of periodontal ligament cells in periodontitis is impaired partly due to decreased RUNX2 expression. Mass spectrometry identified TRIM21 as a protein that interacts with RUNX2 and facilitates its degradation. Pharm...
Improving hepatic metabolic function with 3D iPSC-derived human hepatocytes [0.03%]
使用三维诱导多能干细胞衍生的人肝细胞改善肝脏代谢功能
Victoria Pozo Garcia,Mostafa Kiamehr,Robin Versteegden et al.
Victoria Pozo Garcia et al.
Human induced pluripotent stem cells (iPSCs) have the potential to significantly advance drug discovery and clinical applications, particularly in personalized medicine. Synthetic biocompatible materials improve the reproducibility and effi...
Protein phosphatase 2A/Hedgehog pathway governs efferocytosis of pulmonary macrophages and participates in nanoplastics-induced mouse lung injury [0.03%]
蛋白磷酸酶2A/ Hedgehog信号通路调控肺巨噬细胞的促凋亡作用并参与纳米塑料致小鼠肺损伤
Jiaxin Zhang,Yuwei Zhang,Lixian Wen et al.
Jiaxin Zhang et al.
Although inhalation of nanoplastics (NPs) is widely recognized as a trigger of pulmonary injury, the mechanisms underlying lung damage induced by orally ingested NPs remain largely uncharacterized. Computational toxicology profiling predict...