Adipose-derived CLEC3B promotes osteogenesis through a CLEC3B-IGFBP4-related paracrine axis associated with mitochondrial adaptation in postmenopausal osteoporosis [0.03%]
脂肪来源的CLEC3B通过与线粒体适应相关的CLEC3B-IGFBP4相关旁分泌轴促进绝经后骨质疏松症的成骨作用
Zhihao Xia,Liangliang Wei,Jiajia Ji et al.
Zhihao Xia et al.
Postmenopausal osteoporosis (PMOP) develops within a complex metabolic milieu, but the adipose-derived cues that regulate osteoblast function are not fully defined. Here, plasma ELISA analysis showed preferential elevation of circulating C-...
HP1γ promotes the progression of colorectal cancer through interaction with RBPJ of the Notch signaling pathway [0.03%]
notch信号通路RBPJ的相互作用促进结直肠癌进展
Rui-Bao Zhu,Yi-Jia Xie,Yu-Ting Han et al.
Rui-Bao Zhu et al.
Epigenetic dysregulation plays a pivotal role in cancer progression. Unlike HP1α and HP1β, which localize primarily to heterochromatin, HP1γ predominantly occupies euchromatin, suggesting a direct role in transcriptional regulation. Here...
AMPK orchestrates mitochondrial homeostasis via dynamics and mitophagy to combat hypoxia-induced energetic crisis in keratocytes [0.03%]
AMPK通过线粒体动力学和线粒体自噬调控角膜细胞缺氧诱导的能量危机
Xinlin Yan,Yi Guan,Guozhen Chen et al.
Xinlin Yan et al.
Background: Hypoxia disrupts corneal stromal physiology and alters cellular energy metabolism. This study aimed to elucidate the molecular role of the cellular energy sensor AMP-activated protein kinase (AMPK) in modulati...
GPNMB regulates EGFR mitochondrial translocation via HK2, influencing microglial respiratory chain and metabolic defects to promote polarization and stroke progression [0.03%]
GPNMB通过HK2调节EGFR线粒体易位，影响小胶质细胞呼吸链和代谢缺陷，促进极化和卒中进展
Chang Gao,Qiong Nie,Yongnan Hao et al.
Chang Gao et al.
Background: One of the main reasons of disability and death is stroke in China and other countries, with growing evidence pointing to the role of microglial polarization in its pathogenesis. Epidermal growth factor recept...
IGF2BP3 promotes glycolysis of osteosarcoma stem cells by reading RNA m⁶A to stabilize ENO1 and promote malignant biological behavior of osteosarcoma [0.03%]
IGF2BP3通过阅读RNA的m⁶A来促进骨肉瘤干细胞的糖酵解并稳定ENO1从而促进骨肉瘤恶性生物学行为
Binglun Zhang,Xue Ren,Bo Wang et al.
Binglun Zhang et al.
Osteosarcoma stem cells (OSSCs) play a central role in driving osteosarcoma (OS) progression by promoting migration, proliferation, self-renewal, chemotherapy resistance, and immune evasion. However, the molecular mechanisms that sustain st...
Mechanism of palytoxin-induced ferroptosis in HaCaT cells via targeting TrxR1 [0.03%]
通过靶向TrxR1介导的海洋雪毒诱发HaCaT细胞铁死亡的作用机制研究
Cheng Zhong,Zihan Zhao,Dong Chen et al.
Cheng Zhong et al.
PLTX (Palytoxin) is a fatty-chain polyether marine biotoxin originally produced by benthic dinoflagellates, particularly Ostreopsis ovata and Ostreopsis siamensis. Via the marine food web, PLTX bioaccumulates in numerous organisms such as c...
Effects of ethanol and acetaldehyde on multi-organ genomic mutation landscapes [0.03%]
乙醇和乙醛对多器官基因组突变谱的影响
Bérénice Chavanel,Eva Tibaldi,François Virard et al.
Bérénice Chavanel et al.
Alcohol consumption is a major risk factor for cancer, particularly of the head and neck. Acetaldehyde, the main ethanol metabolite, is linked to oral carcinogenesis, but the mechanisms are not well understood. While some mutational signatu...
Inhibition of YTHDF2-mediated CYLD mRNA degradation promotes neuronal ferroptosis and pain in Parkinson's disease through NOX4 deubiquitination [0.03%]
YTHDF2介导的CYLD mRNA降解抑制通过NOX4去泛素化促进帕金森病神经元铁死亡和疼痛
Fei Wang,Shuwei Bai,Yuanmei Pan et al.
Fei Wang et al.
Background: Parkinson's disease (PD) is featured by progressive neurodegeneration linked to iron-dependent ferroptosis, yet the functions of m6A RNA-binding proteins and deubiquitinating enzymes in this process remain poo...
Single-cell immunoprofiling reveals a dysfunctional-like immune microenvironment and malignant phenotype in aging penile squamous cell carcinoma [0.03%]
单细胞免疫分析揭示阴茎鳞状细胞癌衰老的免疫微环境和恶性表型
Jian Cao,Lin Du,Zailong Qin et al.
Jian Cao et al.
Background: Penile squamous cell carcinoma (PSCC) can affect men of any age, but we know little about the differences between non-old and old patients with PSCC, which severely limits the precise diagnosis and treatment o...
Circular RNA circTrpc6-induced tau phosphorylation contributes to neuronal injury and cognitive decline via miR-485-5p/eIF4E axis in senescence-accelerated mouse prone 8 mice [0.03%]
circTrpc6通过miR-485-5p/eIF4E轴诱导tau磷酸化参与衰老加速系易患8型小鼠的神经元损伤和认知障碍
Jin-Lan Huang,Qiu-Qing Yan,Yan-Bin Guo et al.
Jin-Lan Huang et al.
Tau hyperphosphorylation, a key neuropathological feature in neurodegenerative disorders, is strongly linked to cognitive decline. CircRNAs are recognized to play a crucial regulatory role in numerous human diseases, yet their impacts on ne...