The novel sphingosine-1-phosphate receptor modulator KRP-203 prevents myocardial ischemia-reperfusion injury by preserving mitochondrial function through activation of the RISK and SAFE signaling pathways [0.03%]
新型鞘氨醇-1-磷酸受体调节剂KRP-203通过活化RISK和SAFE信号途径保存线粒体功能从而预防心肌缺血再灌注损伤
Nan Wu,Linyuan Wang,Shuang Yu et al.
Nan Wu et al.
KRP-203, a novel agonist of sphingosine-1-phosphate receptors (S1PRs), has shown promise in treating in immune-related diseases by blocking lymphocyte recruitment to inflamed tissues. Although S1PRs are abundantly expressed in cardiomyocyte...
NAD + in fatty liver disease: mechanistic insights and associated targets [0.03%]
脂肪肝病中的NAD+：机制见解和相关靶点
Yaxin Guo,Yuting Wang,Shiran Wu et al.
Yaxin Guo et al.
Fatty liver disease, encompassing metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease (ALD), is frequently linked to high-calorie diets, excessive alcohol consumption, or other metabolic dis...
Hepatocyte nuclear factor 1 in renal lipid metabolism: molecular mechanisms and therapeutic potentials [0.03%]
肝细胞核因子1在肾脂代谢中的作用：分子机制和治疗潜力
Wenhui Zhu,Wenfan Wang,Yayun Wang et al.
Wenhui Zhu et al.
Kidney disease is increasingly linked to dysregulated lipid metabolism, yet the molecular mechanisms driving renal lipotoxicity remain poorly understood. This review elucidates the pivotal role of the hepatic nuclear factor-1 family (HNF-1...
Effects of TA-65 on telomere length, functional outcomes, and inflammation: a systematic review and meta-analysis [0.03%]
TA65对端粒长度、功能结局及炎症影响的系统评价和meta分析
Xiaojuan Su,Cheng Wang,Zhixian Gou et al.
Xiaojuan Su et al.
Background: TA-65®, a telomerase-activating compound derived from Astragalus membranaceus, has garnered interest for its potential to modulate cellular aging. However, its mechanistic efficacy and long-term toxicological...
The Leupaxin/HDAC6/EGR2 axis facilitates breast cancer progression by enhancing macrophage M2 polarization [0.03%]
LEUPAXIN/HDAC6/EGR2轴通过增强M2型巨噬细胞极化促进乳腺癌进展
Shaozhong He,Qun Wang,Jiayi He et al.
Shaozhong He et al.
Macrophage M2 polarization plays a pivotal role in breast cancer development. The present study aimed to investigate the interplay of the Leupaxin (LPXN)/HDAC6/EGR2 axis in breast cancer and its impact on macrophage M2 polarization. Our fin...
Wanchun Zhu,Lihong Fu,Yu Cui et al.
Wanchun Zhu et al.
Liver fibrosis, a common manifestation in numerous hepatic diseases, is critical in the progression from mild injury to cirrhosis and ultimately to hepatocellular carcinoma. To date, there are no effective pharmacological therapies for live...
Repeated ketamine exposure induces psychotic-like behaviors in mice via DRD1-mediated phosphorylation of p-Thr34 DARPP-32 and p-Ser10 histone H3 [0.03%]
反复接触氯胺酮可通过多巴胺D1受体介导的p-Thr34DARPP-32和p-Ser10组蛋白H3磷酸化在小鼠中诱发类似精神的症状
Peng Lv,Jiayu Zhang,Jia-Yi Wei et al.
Peng Lv et al.
Psychotic disorders frequently result from repeated ketamine exposure, yet the underlying mechanisms remain elusive. We propose that repeated exposure to ketamine may induce psychotic-like behaviors via DRD1-mediated nuclear signaling pathw...
SENP3 mediated DeSUMOylation of macrophage derived CCL17 accelerates atherosclerosis via regulation of Treg [0.03%]
SENP3介导的巨噬细胞来源CCL17去SUMO化通过调控Tregs促进动脉粥样硬化形成
Xiliang Zhao,Fenfang Zhang,Jianjun Du et al.
Xiliang Zhao et al.
Background: Atherosclerosis (AS) is a cardiovascular problem, which is featured by the accumulation of lipids in the intimal layer of the arterial wall and inflammatory reaction of immune cells. CCL17 is an inflammatory m...
CBX6 induces CD8+ T cell exhaustion and tumor development in esophageal squamous cell carcinoma through SMARCD1-mediated CCL8 secretion and lactate efflux [0.03%]
CBX6通过SMARCD1介导的CCL8分泌和乳酸流出诱导食管鳞状细胞癌中CD8⁺T细胞衰竭及肿瘤发生
Lihua Wang,Guoqing Liu,Qilan Huang et al.
Lihua Wang et al.
This study investigates the functions of chromobox 6 (CBX6) in esophageal squamous cell carcinoma (ESCC) and delves into its functional mechanisms. The bioinformatics insights suggested that CBX6 was overexpressed in ESCC and linked to dism...
Keerthana Hemadri,Poorvi Subramanian,Sivaroopan Aravindan et al.
Keerthana Hemadri et al.
Lipolysis, a tightly regulated metabolic process, is hijacked by cancer cells to meet their energy and biosynthetic demands under stress. Central to this process is hormone-sensitive lipase (HSL), a key enzyme that orchestrates lipid mobili...