Enhancing cardiac repair post-myocardial infarction: a study on GATM/Gel hydrogel therapeutics [0.03%]
心肌梗死后心脏修复的增强：GATM /凝胶水凝胶治疗的研究
Te Li,Lijuan Ding,Qiang Wang et al.
Te Li et al.
Background and purpose: Significant advancements in therapeutic approaches are imperative to address the prevalent impact of myocardial infarction (MI) on morbidity and mortality rates worldwide. This study explores the t...
Pan-cancer and multi-omics analysis: NDUFA1 is a potential therapeutic target and prognostic marker for esophageal cancer [0.03%]
泛癌及多组学分析：NDUFA1是治疗食管癌的潜在靶点和预后标志物
Rui Yin,Gai Zhou,Guanqi Liu et al.
Rui Yin et al.
Objectives: The study examined the NDUFA1 expression and its prognostic value in pan-cancer, especially in esophageal cancer (ESCA). Its carcinogenic effect on ESCA was further elucidated. ...
CPT1A mediates succinylation of LDHA at K318 site promoteing metabolic reprogramming in NK/T-cell lymphoma nasal type [0.03%]
CPT1A介导的LDHA K318位点琥珀酰化促进鼻型NK/T细胞淋巴瘤代谢重编程
Hao Tian,Yi Ge,Jianjun Yu et al.
Hao Tian et al.
Carnitine palmitoyltransferase 1A (CPT1A), a succinylating enzyme, is highly expressed in various malignant tumors and promotes tumor progression. Succinylation is a posttranslational modification that has been reported in various diseases,...
Transcriptomic profiles of single-cell autophagy-related genes (ATGs) in lung diseases [0.03%]
肺部疾病中单细胞自噬相关基因（ATGs）的转录组谱型分析
Xuanqi Liu,Linlin Zhang,Liyang Li et al.
Xuanqi Liu et al.
Autophagy related genes (ATGs) play essential roles in maintaining cellular functions, although biological and pathological alterations of ATG phenotypes remain poorly understood. To address this knowledge gap, we utilized the single-cell s...
UHRF1 promotes calcium oxalate-induced renal fibrosis by renal lipid deposition via bridging AMPK dephosphorylation [0.03%]
UHRF1通过肾脂质沉积促进AMPK去磷酸化从而促进草酸钙诱导的肾纤维化
Yushi Sun,Bojun Li,Baofeng Song et al.
Yushi Sun et al.
Background: Nephrolithiasis, a common urinary system disorder, exhibits high morbidity and recurrence rates, correlating with renal dysfunction and the increased risk of chronic kidney disease. Nonetheless, the precise ro...
Esketamine alleviates depressive-like behavior in neuropathic pain mice through the METTL3-GluA1 pathway [0.03%]
通过METTL3-GluA1通路埃斯西泰帕胺改善神经病理性疼痛小鼠的类似抑郁的行为反应
Xiaoming Ji,Zhimin Huang,Chenming Zhou et al.
Xiaoming Ji et al.
Esketamine, a newly developed antidepressant, is the subject of this research which seeks to explore its impact on depressive symptoms in neuropathic pain mice and the potential molecular mechanisms involved. Through transcriptome sequencin...
Comparative characterization of organ-specific phase I and II biotransformation enzyme kinetics in salmonid S9 sub-cellular fractions and cell lines [0.03%]
鲑科鱼类器官特异性相I和相II生物转化酶动力学的比较研究及亚细胞组分和细胞系中的特征
Baptiste P M Martin,Marco E Franco,Kristin Schirmer
Baptiste P M Martin
Advancing in vitro systems to address the effects of chemical pollution requires a thorough characterization of their functionalities, such as their repertoire of biotransformation enzymes. Currently, knowledge regarding the presence, activ...
Comparative Study
Cell biology and toxicology. 2025 Jan 28;41(1):37. DOI:10.1007/s10565-025-09992-8 2025
HSP27/IL-6 axis promotes OSCC chemoresistance, invasion and migration by orchestrating macrophages via a positive feedback loop [0.03%]
HSP27/IL-6轴通过正反馈环调控巨噬细胞促进OSCC的化疗耐药、侵袭和迁移
Ying Qi,Juan Cao,Mingjing Jiang et al.
Ying Qi et al.
Novel strategies to disrupt tumor progression have emerged from studying the interactions between tumor cells and tumor-associated macrophages (TAMs). However, the molecular mechanisms of interactions between tumor cells and TAMs underlying...
Targeting p38γ synergistically enhances sorafenib-induced cytotoxicity in hepatocellular carcinoma [0.03%]
靶向p38γ能够协同增强索拉非尼对肝癌细胞的毒杀效应
Chen Huang,Chenliang Zhang,Jiajin Li et al.
Chen Huang et al.
Sorafenib (Sora) is a first-line treatment for patients with advanced hepatocellular carcinoma (HCC). It can significantly improve the survival rate of patients with advanced HCC, but it is prone to drug resistance during treatment, so the ...
Manganese exposure induces parkinsonism-like symptoms by Serpina3n-TFEB-v/p-ATPase signaling mediated lysosomal dysfunction [0.03%]
锰暴露通过Serpina3n-TFEB-v/p-ATPase信号介导的溶酶体功能障碍诱导类似帕金森症的症状
Huihui Hong,Sicheng Liu,Ting Yang et al.
Huihui Hong et al.
Manganese (Mn) is a neurotoxin that has been etiologically linked to the development of neurodegenerative diseases in the case of overexposure. It is widely accepted that overexposure to Mn leads to manganism, which has clinical symptoms si...