The microRNA-mediated apoptotic signaling axis in male reproduction: a possible and targetable culprit in male infertility [0.03%]
微小核糖核酸介导的雄性生殖凋亡信号轴：男性不育的可能原因及可调控靶点
Pengxia Yu,Xue Zhao,Dan Zhou et al.
Pengxia Yu et al.
Recently, infertility has emerged as a significant and prevalent public health concern warranting considerable attention. Apoptosis, recognized as programmed cell death, constitutes a crucial process essential for the maintenance of normal ...
Glycolysis regulates palatal mesenchyme proliferation through Pten-Glut1 axis via Pten classical and non-classical pathways [0.03%]
糖酵解通过Pten-Glut1轴及其经典和非经典途径调控腭间充质细胞的增殖
Yijia Wang,Xia Peng,Xiaotong Wang et al.
Yijia Wang et al.
Abnormal embryonic development leads to the formation of cleft palate (CP) which is difficult to be detected by genetic screening and needs sequent treatment from infants to adults. There are no interceptive treatment about CP until now. Ge...
Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer [0.03%]
ZC3H13介导的铁死亡在三阴性乳腺癌阿霉素耐药中的分子机制研究
Li Huang,Lei Han,Shuai Liang et al.
Li Huang et al.
Background: Triple negative breast cancer (TNBC) continues to be the most aggressive subtype of breast cancer that frequently develops resistance to chemotherapy. Doxorubicin (DOX) belongs to the anthracycline chemical cl...
MCM8 promotes NR4A1-mediated E2F1 transcription and facilitates renal cell carcinoma through enhancing aerobic glycolysis [0.03%]
MCM8促进NR4A1介导的E2F1转录并促进肾细胞癌通过增强有氧糖酵解过程
Shaobo Zhang,Haoqi Miao,Tian Han et al.
Shaobo Zhang et al.
Renal cell carcinoma (RCC) is a type of renal malignancy originated from the urinary tubular epithelial system. Despite its high incidence, the molecular mechanisms driving its pathogenesis remain poorly understood, limiting therapeutic adv...
Therapeutic role of hucMSC-sEV-enriched miR-13896 in cisplatin-induced acute kidney injury through M2 macrophage polarization [0.03%]
通过M2巨噬细胞极化，hucMSC-sEV富集的miR-13896在顺铂诱导的急性肾损伤中的治疗作用
Can Jin,Peipei Wu,Wei Wu et al.
Can Jin et al.
Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hucMSC-sEV) have recently garnered attention as a potential therapeutic approach for kidney diseases with anti-inflammatory effects. Infiltrated macrophages pl...
Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage, and regeneration response after cisplatin [0.03%]
时空转录组学分析揭示顺铂对肾脏毒性的不同反应，DNA损伤和再生反应
Lukas S Wijaya,Steven J Kunnen,Panuwat Trairatphisan et al.
Lukas S Wijaya et al.
Nephrotoxicity caused by drug or chemical exposure involves complex mechanisms as well as a temporal integration of injury and repair responses in different nephron segments. Distinct cellular transcriptional programs regulate the time-depe...
Trps1 regulates mouse zygotic genome activation and preimplantation embryo development via the PDE4D/AKT/CREB signaling pathway [0.03%]
Trps1通过PDE4D/AKT/CREB信号通路调控小鼠合子基因组激活及着床前胚胎发育
Xia Jiang,Weiwei Xu,Jiandong Sun et al.
Xia Jiang et al.
Despite zygotic genome activation (ZGA) is crucial for early embryonic development, its regulatory mechanism is still unclear in mammals. In the present study, we demonstrate that TRPS1, a maternal factor, plays an essential role in mouse e...
Therapeutic implications of endoplasmic reticulum stress gene CCL3 in cervical squamous cell carcinoma [0.03%]
内质网应激基因CCL3在宫颈鳞癌治疗中的意义
Yingping Zhu,Wei Xu,Yuanfang He et al.
Yingping Zhu et al.
This study investigated ERS-related gene expressions in CESC, identifying two molecular subtypes, P1 and P2, and constructing a precise prognostic model based on these subtypes. TCGA's whole-genome expression profiles were used to recognize...
Impaired olfactory bulb neurogenesis mediated by Notch1 contributes to olfactory dysfunction in mice chronically exposed to methamphetamine [0.03%]
甲基苯丙胺致嗅球神经发生障碍介导小鼠嗅觉功能障碍
Cihang Gu,Zhuo Wang,Wenyu Luo et al.
Cihang Gu et al.
Methamphetamine (Meth) is a potent central nervous system stimulant with high addictive potential and neurotoxic effects. Chronic use results in significant damage in various brain functions, including cognition, memory, and sensory percept...
Repair mechanisms of bone system tissues based on comprehensive perspective of multi-omics [0.03%]
基于多组学综合视角的骨系统组织修复机制
Honghao Yu,Shize Yang,Tianlong Jiang et al.
Honghao Yu et al.
Bone disorders affect more than half of the adult population worldwide who may have a poor quality of life and physical independence worldwide. Multi-omic techniques are increasingly adopted and applied to determine the molecular mechanisms...