Sodium fluoride promotes myopia progression via the activation of the ferroptosis pathway by PIEZO1 and pharmacological targeting PIEZO1 represents an innovative approach for myopia treatment [0.03%]
钠氟化物通过PIEZO1激活铁死亡途径促进近视进展，药理靶向PIEZO1代表了治疗近视的创新方法
Bo Liu,Xueting Yao,Qinying Huang et al.
Bo Liu et al.
Sodium fluoride-induced ocular damage constitutes a significant public health concern globally; however, the precise molecular mechanisms underlying this issue remain obscure. This study aims to investigate the effects of sodium fluoride on...
Insights into emerging mechanisms of ferroptosis: new regulators for cancer therapeutics [0.03%]
铁死亡新兴机制的见解：癌症治疗的新调节因子
Si-Yi Xu,Shuang-Shuang Yin,Lei Wang et al.
Si-Yi Xu et al.
Ferroptosis is an iron-dependent form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides, which has been implicated in the pathogenesis of various diseases, and therapeutic agents targeting ferroptos...
Myeloid cells are involved in tumor immunity, metastasis and metabolism in tumor microenvironment [0.03%]
髓系细胞参与肿瘤免疫，转移和肿瘤微环境中的代谢过程
Chenbo Zhang,Ying Song,Huanming Yang et al.
Chenbo Zhang et al.
Bone marrow-derived cells in the tumor microenvironment, including macrophages, neutrophils, dendritic cells, myeloid-derived suppressor cells, eosinophils and basophils, participate in the generation, development, invasion and metastasis o...
Olfactory mucosal mesenchymal stem cell-derived exosome Lnc A2M-AS1 ameliorates oxidative stress by regulating TP53INP1-mediated mitochondrial autophagy through interacting with IGF2BP1 in Parkinson's diseases [0.03%]
嗅粘膜间充质干细胞衍生的外泌体Lnc A2M-AS1通过与IGF2BP1相互作用调节TP53INP1介导的线粒体自噬来改善帕金森病中的氧化应激
Jiangshan Zhang,Chuang Wang,Guoshuai Yang et al.
Jiangshan Zhang et al.
Background: Exosome Lnc A2M-AS1 from olfactory mucosa mesenchymal stem cells (OM-MSCs) can ameliorate oxidative stress by improving mitophagy in cardiomuscular cells; however, it remains unclear whether this effect exists...
CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer [0.03%]
CUL1-r连接异戊二烯化促进p27的K29链接泛素化，以实现索拉非尼抗性肝癌中的自噬降解
Haitao Xu,Shaoyue Zheng,Qiuqi Zhang et al.
Haitao Xu et al.
Sorafenib has demonstrated great efficacy in liver cancer, however, its application as first-line treatment has been hampered due to the emerging drug resistance. This study is aimed to investigate the mechanism underlying acquired sorafeni...
Hairui Yu,Dong Wei,Weiqian Liao et al.
Hairui Yu et al.
The progression of coronary artery disease atherosclerosis (CAD) is closely associated with cardiomyocyte apoptosis and inflammatory responses. This study focused on investigating the impact of BRCA1 in exosomes (Exo) derived from M1 macrop...
Transcriptomic changes in oxidative stress, immunity, and cancer pathways caused by cannabis vapor on alveolar epithelial cells [0.03%]
大麻蒸汽对肺泡上皮细胞引起的氧化应激、免疫和癌症通路的转录组变化
Emily T Wilson,Percival Graham,David H Eidelman et al.
Emily T Wilson et al.
As legalization of cannabis increases worldwide, vaping cannabis is gaining popularity due to the belief that it is less harmful than smoking cannabis. However, the safety of cannabis vaping remains untested. To address this, we developed a...
Targeted nanoparticle delivery system for tumor-associated macrophage reprogramming to enhance TNBC therapy [0.03%]
用于重编程肿瘤相关巨噬细胞以增强TNBC疗法的靶向纳米颗粒递送系统
Xiaoshen Dong,Xiaoou Wang,Xinyu Zheng et al.
Xiaoshen Dong et al.
Triple-negative breast cancer (TNBC) poses as a daunting and intricate manifestation of breast cancer, highlighted by few treatment options and a poor outlook. The crucial element in fostering tumor growth and immune resistance is the polar...
Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway [0.03%]
穿心莲内酯通过FKBP1A介导的NOTCH1/AKT通路减轻内质网应激从而改善脓毒症诱导的急性肝损伤
Jiaqi He,Zepeng Huang,Rui Zou
Jiaqi He
Andrographolide (AP) has been shown to possess anti-inflammatory activities. In this study, the impact of AP in sepsis-induced acute liver injury (ALI) and the molecules involved were dissected. FKBP1A was predicted to be the sole target pr...
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65 [0.03%]
中性粒细胞衍生的肝素结合蛋白通过促进TRIM21和P65的泛素化增加急性肺损伤中的内皮通透性
Jian Zhang,Yong Cao,Wenqi Shu et al.
Jian Zhang et al.
Acute lung injury (ALI), which poses a significant public health threat, is commonly caused by sepsis. ALI is associated with permeability and glycolysis changes in pulmonary microvascular endothelial cells. Our study demonstrates that hepa...