Genetic profiling of human cell lines used as in vitro model to study cardiovascular pathophysiology and pharmacotoxicology [0.03%]
人细胞系的基因分型：用于心血管病理生理学和药理毒理学研究的体外模型
Elise Jeannesson,Gérard Siest,Mohamed Zaiou et al.
Elise Jeannesson et al.
Background: Cell lines are widely used to monitor drug pharmacokinetics and pharmacodynamics and to investigate a number of biochemical mechanisms. However, little is known about the genetic profile of these in vitro mode...
Short-term vitamin A supplementation at therapeutic doses induces a pro-oxidative state in the hepatic environment and facilitates calcium-ion-induced oxidative stress in rat liver mitochondria independently from permeability transition pore formation : detrimental effects of vitamin A supplementation on rat liver redox and bioenergetic states homeostas [0.03%]
短期内以治疗剂量摄取维生素A会在肝脏环境中诱发促氧化状态，并且会独立于渗透性转换孔的形成而促进钙离子诱导的氧化应激：维生素A补充对大鼠肝氧化-还原和生物能量稳态的不利影响
Marcos Roberto de Oliveira,Max William Soares Oliveira,Rodrigo Lorenzi et al.
Marcos Roberto de Oliveira et al.
There is a growing body of evidence showing that vitamin A induces toxic effects in several experimental models and in human beings. In the present work, we have investigated the effects of short-term vitamin A supplementation on the adult ...
Transdentinal diffusion and cytotoxicity of self-etching adhesive systems [0.03%]
自酸蚀粘结系统的牙本质渗透及细胞毒性研究
Célia Regina Moreira Lanza,Carlos Alberto de Souza Costa,Maysa Furlan et al.
Célia Regina Moreira Lanza et al.
Objective: To evaluated the transdentinal diffusion and subsequent cytotoxicity of self-etching adhesives on odontoblast-like cells. Materials and methods...
V Matranga,Y Yokota
V Matranga
Studies on the effects of a variety of exogenous and anthropogenic environmental factors, including endocrine disruptors, heavy metals, UV light, high temperature, and others, on marine organisms have been presented at the 2nd Bilateral Sem...
Toxicity of phospholipases A2 D49 (6-1 and 6-2) and K49 (Bj-VII) from Bothrops jararacussu venom [0.03%]
巴氏尊蛇毒中的磷脂酶A2D49（6-1和6-2）和K49（Bj-VII）的毒性作用研究
V L Bonfim,D D de Carvalho,L A Ponce-Soto et al.
V L Bonfim et al.
Purified phospholipase A2 (PLA2) enzymes from Bothrops jararacussu snake venom were examined to evaluate NIH 3T3 and COS7 fibroblast cytotoxicity, as well as muscle myotoxic and inflammatory activities. Separation of fractions Bj-VII (from ...
Environmental sensing and response genes in cnidaria: the chemical defensome in the sea anemone Nematostella vectensis [0.03%]
刺胞动物中的环境感应和响应基因：海葵Nematostella vectensis中的化学防御系统
J V Goldstone
J V Goldstone
The starlet sea anemone Nematostella vectensis has been recently established as a new model system for the study of the evolution of developmental processes, as cnidaria occupy a key evolutionary position at the base of the bilateria. Cnida...
Transcriptome profiling in crustaceans as a tool for ecotoxicogenomics: Daphnia magna DNA microarray [0.03%]
水生无脊椎动物毒理组学的转录谱分析：Daphnia magna DNA芯片研究
Hajime Watanabe,Kaoru Kobayashi,Yasuhiko Kato et al.
Hajime Watanabe et al.
Chemicals released into the environment have the potential to affect various species and it is important to evaluate such chemical effect on ecosystems, including aquatic organisms. Among aquatic organisms, Daphnia magna has been used exten...
Correlation between scaffold in vivo biocompatibility and in vitro cell compatibility using mesenchymal and mononuclear cell cultures [0.03%]
采用间充质干细胞和单个核细胞培养评估支架材料的体内相容性和体外细胞相容性的相关性研究
Y K Seo,H H Yoon,Y S Park et al.
Y K Seo et al.
The aim of this study was to compare the cell compatibility of silk and polyglycolic acid (PGA) scaffolds cultured in vitro with mesenchymal stem cells (MSCs) and peripheral blood mononuclear cells (PBMCs) to their biocompatibility in vivo ...
Role of impaired DNA repair in genotoxic susceptibility of patients with head and neck cancer [0.03%]
头颈癌患者中DNA修复缺陷所致的遗传毒性的易感性
Pawel Rusin,Jurek Olszewski,Alina Morawiec-Bajda et al.
Pawel Rusin et al.
DNA repair is critical for genotoxic susceptibility and cancer development. Forty-seven patients with head and neck squamous cell carcinoma (HNSCC) and 38 healthy controls were enrolled in this study. Among the patients, 16 subjects had met...
Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat [0.03%]
汉诺威韦斯特大鼠四氯化碳致肝纤维化尿蛋白组分的鉴定及动态分析
Rosemary Smyth,Catherine S Lane,Rukhsana Ashiq et al.
Rosemary Smyth et al.
Proteomic techniques such as two-dimensional gel electrophoresis (2-DGE) and mass spectrometry have become important tools for the identification of novel biomarkers of toxicity and disease. Ideally, such biomarkers need to be sensitive and...