Lipotoxicity, lipid peroxidation and ferroptosis: a dilemma in cancer therapy [0.03%]
脂毒性和脂质过氧化以及铁死亡：癌症治疗中的两难困境
Chuhan Ma,Huixin Hu,Hao Liu et al.
Chuhan Ma et al.
The vulnerability of tumor cells to lipid peroxidation, driven by redox imbalance and lipid overabundance within the tumor microenvironment (TME), has become a focal point for novel antitumor strategies. Ferroptosis, a form of regulated cel...
Ubiquitin-specific peptidase 10 attenuates bleomycin-induced pulmonary fibrosis via modulating autophagy depending on sirtuin 6-mediated AKT/mTOR [0.03%]
泛素特异性肽酶10通过依赖SIRT6介导的AKT / mTOR调节自噬来缓解博莱霉素诱导的肺纤维化
Shitao Mao,Na Yu,Wei Wang et al.
Shitao Mao et al.
Idiopathic pulmonary fibrosis (IPF), characterized by fibroblast activation and collagen deposition, is a progressive lung disease that lacks effective interventions. Ubiquitin-specific peptidase 10 (USP10) acts as a multifunctional player ...
Machine learning-based identification of cuproptosis-related lncRNA biomarkers in diffuse large B-cell lymphoma [0.03%]
基于机器学习的弥漫性大B细胞淋巴瘤中铜死亡相关长链非编码RNA生物标志物识别
Wenhao Ouyang,Zijia Lai,Hong Huang et al.
Wenhao Ouyang et al.
Multiple machine learning techniques were employed to identify key long non-coding RNA (lncRNA) biomarkers associated with cuproptosis in Diffuse Large B-Cell Lymphoma (DLBCL). Data from the TCGA and GEO databases facilitated the identifica...
Npc1 gene mutation impairs multilineage differentiation potential of hepatic telocytes in murine models [0.03%]
Npc1基因突变损害小鼠模型肝.tel细胞的多线分化潜能
Jichao Yang,Yuqiao Chang,Liang Qiao et al.
Jichao Yang et al.
Objective: To investigate the effect of the Npc1 gene on the biological activity of Telocytes (TCs) in the liver and to provide theoretical support for further research on the biological activity of TCs. ...
Effect of the MIAT/microRNA 130a-3p/Pdgfra axis on retinal microglia activation in mice with chronic retinal hypoperfusion injury [0.03%]
MIAT/miR-130a-3p/PDGFRα轴对慢性视网膜低灌注损伤小胶质细胞活化的影响
Qingqing Sun,Lei Zhang,Guanghua Zhou et al.
Qingqing Sun et al.
This paper aimed to address the function of the MIAT/miR-130a-3p/Pdgfra axis in retinal microglia activation in chronic retinal hypoperfusion injury (CRHI) mice. CRHI mouse models were constructed through bilateral common carotid artery occ...
Based exploration of the diagnostic value of oxidative stress-related key genes in chronic obstructive pulmonary disease [0.03%]
基于氧化应激相关关键基因的慢性阻塞性肺疾病的诊断价值研究
Shenglan Wang,MingFeng Zhong,Xiaoli Deng et al.
Shenglan Wang et al.
Chronic obstructive pulmonary disease (COPD) ranks as the third most common contributor to global mortality. Oxidative stress has been recognized as a critical driver of multiple interacting mechanisms in COPD development. This research inv...
Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia [0.03%]
子痫前期的蜕膜circ-Hdac4/miR-30c/RBPJ轴失调影响胎盘功能
Yan Su,Jing Long,Jiani Diao et al.
Yan Su et al.
Embryo implantation relies on complex mother-fetus interactions. Abnormal decidualization can cause various pregnancy complications such as placental abnormalities, preeclampsia, and fetal growth restriction. circRNAs play a key role in var...
Targeting B4GALT3 in BMSCs-EVs for Therapeutic Control of HCC via NF-κB pathway inhibition [0.03%]
靶向调控BMSCs-EV中B4GALT3对NF-κB信号通路抑制及肝癌治疗作用
Juncheng Guo,Kaiqiong Wang,Qigang Sun et al.
Juncheng Guo et al.
Examining the communications in the tumor microenvironment (TME) specific to hepatocellular carcinoma (HCC), this exploration looks into the role played by beta-1,4-Galactosyltransferase III (B4GALT3) in bone marrow mesenchymal stromal cell...
Laura Vilardo,Ingrid Cifola,Marta Nardella et al.
Laura Vilardo et al.
Lamin A/C is a nuclear type V intermediate filament protein part of the meshwork structure underlying the inner nuclear membrane (nuclear lamina), which plays numerous roles, including maintenance of nuclear shape, heterochromatin organizat...
Early endolysosomal dysfunction is a contributing factor to gadolinium-based contrast agent mouse renal proximal tubule epithelial cell injury [0.03%]
早期溶酶体功能障碍是钆基对比剂损伤小鼠肾脏近曲管上皮细胞的促成因素
Joshua DeAguero,Tamara Howard,G Patricia Escobar et al.
Joshua DeAguero et al.
The prevalence of contrast-enhanced magnetic resonance imaging (MRI) examinations and the absence of safer alternatives to gadolinium-based contrast agents (GBCAs) make the associated adverse effects of GBCAs much more concerning. Safety co...