Gut microbiota metabolites positively impacts chemotherapy effects in colorectal cancer [0.03%]
肠道微生物代谢产物可促进结直肠癌化疗效果
Sara Gomes,Sara Granja,Luana A Osório et al.
Sara Gomes et al.
Colorectal cancer (CRC) remains one of the leading causes of cancer-related deaths worldwide, largely due to late-stage diagnosis and limited efficacy of current therapies. 5-Fluorouracil (5-FU) is the standard chemotherapeutic agent used i...
ZFP36-mediated ZBP1 degradation inhibits microglia pro-inflammatory and NLRP3 inflammasome activation in Alzheimer's disease [0.03%]
ZFP36介导的ZBP1降解抑制小胶质细胞促炎作用和NLRP3炎症小体活化以治疗阿尔茨海默病
Ting Liu,Dan Chen,Fengjie Liu et al.
Ting Liu et al.
Alzheimer's disease (AD) is a heterogeneous disease with limited treatment efficacy. Identifying novel molecular targets and mechanisms is therefore crucial for developing therapeutic strategies. Zinc finger protein 36 (ZFP36) has not been ...
Embryotoxicity and mixture effects of legacy PFAS in a human iPSC-based 3D model [0.03%]
基于人多能干细胞的三维模型中PFAS毒性及联合作用研究
Andreas Frederik Treschow,Elisa Martiny,Claudia Torero Gutierrez et al.
Andreas Frederik Treschow et al.
Humans are continuously exposed to a wide array of exogenous chemicals via dietary intake, environmental sources, and the use of personal care products. This includes per- and polyfluoroalkyl substances (PFAS), a class of highly persistent ...
E3 ubiquitin ligase trim36 targets ddx3x for degradation to reprogram macrophage polarization and ameliorate tubal factor infertility in rats [0.03%]
E3连接酶TRIM36通过泛素化降解DDX3X重编程巨噬细胞极化以改善大鼠输卵管性不孕
Liang Shao,Nansu Wang,Yan Yan et al.
Liang Shao et al.
Objective: Tubal factor infertility (TFI), a major cause of female infertility, lacks effective therapies and is closely associated with macrophage-mediated inflammation. Although DDX3X regulates macrophage polarization, ...
Targeting SPHK1 by 8-HETrE attenuates MASH-Driven fibrosis via restoration of hepatic stellate cell mitochondrial dynamics [0.03%]
靶向SPHK1的8-HETrE通过恢复肝星状细胞线粒体动力学来缓解MASH介导的纤维化
Shuling Chen,Jiayan Li,Kan Xu et al.
Shuling Chen et al.
Metabolic dysfunction-associated steatohepatitis (MASH) drives hepatic stellate cell (HSC) activation and extracellular matrix deposition, leading to liver fibrosis, for which effective treatments remain lacking. Here, we report that 8-hydr...
Nanoplastic toxicity and uptake in kidney cells: differential effects of concentration, particle size, and polymer type [0.03%]
纳米塑料的肾脏细胞毒性和吸收作用：浓度、颗粒大小和聚合物类型的不同效应
Hayden Louis Gillings,Darling M Rojas-Canales,Soon Wei Wong et al.
Hayden Louis Gillings et al.
Nanoplastics (NPs, < 1 µm) are emerging environmental contaminants capable of crossing biological barriers and interacting at the cellular and subcellular level. Despite evidence of microplastics in human kidney tissue and urine, the renal...
SIRT3 attenuates AGEs-induced senescence in human granulosa cells through enhancing mitophagy [0.03%]
SIRT3通过增强线粒体自噬缓解人颗粒细胞 advanced glycation end-products (AGEs)诱导的衰老
Shuhang Li,Mingge Tang,Sihui Zhu et al.
Shuhang Li et al.
Age-related decreases in follicle numbers and oocyte quality are major contributors to the decline in female fertility, which is associated with increased infertility rates. Emerging evidence suggests that targeting granulosa cell senescenc...
BMSC-derived extracellular vesicles affect gluconeogenesis and lipogenesis by releasing 5'-tRF-GlyCCC to improve MAFLD insulin sensitivity [0.03%]
脂肪来源的间充质干细胞衍生的外泌体通过释放5'-tRF-GlyCCC影响糖异生和脂质生成以提高MAFLD胰岛素敏感性
Chenyun Yang,Huiling Chen,Xiaojing Huang et al.
Chenyun Yang et al.
TsRNAs (tRNA-derived small RNAs) also known as tRNA-derived small RNAs, are a relatively new type of non-coding RNAs that have demonstrated promising effect in treating various liver diseases. However, the function of small extracellular ve...
Endothelial progenitor cell derived extracellular vesicles promotes wound healing in diabetic mice via activating mobilization and neovascularization [0.03%]
内皮前体细胞源性外泌体通过激活动员和新生血管化促进糖尿病小鼠伤口愈合
Yan Bao,Zhaoxiang Li,Lingjuan Du et al.
Yan Bao et al.
Diabetic patients face delayed wound healing due to angiogenesis dysfunction. This study aims to investigate the function of endothelial progenitor cell (EPC)-derived extracellular vesicles (EVs) in wound healing of diabetic mice, providing...
Harnessing machine learning-driven multiomics integration: deciphering programmed cell death networks for prognostication and immunotherapy prediction in lung adenocarcinoma [0.03%]
利用机器学习驱动的多组学整合：解码程序性细胞死亡网络以预测肺癌腺癌预后和免疫治疗反应
Wuguang Chang,Bin Luo,Zhesheng Wen et al.
Wuguang Chang et al.
Background: Programmed cell death (PCD) patterns play important roles in lung adenocarcinoma (LUAD) development as well as treatment resistance, and in-depth study of PCD is beneficial for improving the therapeutic paradi...