Designing a multi-epitope vaccine against the midgut-specific fibrinogen-related protein 1(FREP1) of Anopheles stephensi to enhance protection against the malaria parasite: a step beyond traditional vaccine development approaches [0.03%]
针对斯蒂芬氏按蚊特异性中肠纤维蛋白相关蛋白1（FREP1）的多表位疟疾疫苗设计：超越传统疫苗开发方法的一大步
Mahima Yadav,Nisha Dahiya,Hitesh Singh et al.
Mahima Yadav et al.
Malaria has been a prominent health burden for decades globally. The complex life cycle of Plasmodium made numerous challenges in finding an effective candidate for developing a potent transmission-blocking vaccine (TBV) against malaria. A ...
Intensification of interfacial enzymatic reactions in oil-water systems using slug flow in adaptive microfluidic channels [0.03%]
采用自适应微流体通道中的分层流强化油水体系界面酶反应
Ruihao Zhu,Maojun Zhao,Xiaoyi Liu et al.
Ruihao Zhu et al.
Lipase is a type of hydrolase that catalyzes reactions at the water-in-oil (O/W) interface and possesses significant applied value across various fields. This study introduces integrated reaction-separation system employing microfluidic slu...
Effects of various physicochemical parameters on the Biofilm formation and Pyocyanin production in Pseudomonas aeruginosa PA14 [0.03%]
各种理化参数对绿脓杆菌PA14生物被膜形成及绿脓素生成的影响
Sautrik Bhattacharya,Aravind Venkatasubramanian,Ananya Chatterjee et al.
Sautrik Bhattacharya et al.
Background: Biofilm formation in Pseudomonas aeruginosa provides protection against multiple stressors and contributes to its pathogenicity. Pyocyanin, a virulence factor regulated by quorum sensing, is crucial for infect...
Identification and characterisation of subtype-specific anti-N-CoR OSGEP protease in acute myeloid leukaemia (AML-M5) cell lineage [0.03%]
急性髓系白血病(M5)细胞亚型中抗-N-CoR OSGEP蛋白酶的鉴定与表征
Sam Annie Jeyachristy,Eshan Rosly Nazem,Ramesh Thevendran et al.
Sam Annie Jeyachristy et al.
Acute myeloid leukemia (AML) is a neoplastic disorder of the myeloid stem cell and is most commonly diagnosed in children and young adults. N-CoR is an essential protein that regulates transcriptional repression in normal myeloid cell devel...
A precisely regulated Streptomyces expression system pTZYp facilitated by the strong promoter stnY and cmt operon [0.03%]
一个由stnY强启动子和cmt操纵子介导的精确调控链霉菌表达系统pTZYp
Kai Zhang,Ao-Yu Wang,Qiang Zhou et al.
Kai Zhang et al.
One of the characteristics of actinomycetes, especially streptomycetes, is the high GC content in their genome, which often leads to the failure of heterologous expression in E. coli, and thus hinders in vitro enzyme activity experiments. T...
Polyhydroxyalkanoate production by Paramecium caudatum isolated from industrial wastewater: a micro eukaryotic host for bioplastic accumulation [0.03%]
一种工业污水来源的草履虫聚羟基烷酸酯生产性能研究：聚羟基烷酸酯合成微生物新宿主探索
Usama Shabbir,Itrat Zahra,Ayesha Liaqat et al.
Usama Shabbir et al.
Paramecium caudatum is a well-known ecotoxicological indicator for monitoring heavy metal pollution, including lead contamination. This study investigates P. caudatum's stress response to lead nitrate through the accumulation of polyhydroxy...
Enhancing HAP3 mediated xylose metabolism and acetic acid metabolism promotes lipid production from lignocellulosic hydrolysate fermented by Candida glycerinogenes [0.03%]
通过HAP3介导的木糖代谢和乙酸盐代谢增强，提高安琪酵母从木质纤维素水解液中产脂性能
Dongqi Jiang,Mengying Wang,Dianfei Wen et al.
Dongqi Jiang et al.
Enhanced Candida glycerinogenes xylose metabolism as well as acetic acid metabolism for lipid production from undetoxified lignocellulosic hydrolysate. The C. glycerinogenes after overexpression of HAP3 increased the xylose assimilation cap...
Improvement in lignin peroxidase oxidative stability via surface display by Bacillus subtilis [0.03%]
芽孢杆菌表面展示提高木质素过氧化物酶的氧化稳定性
Na Shi,De Cheng,Yong Chen et al.
Na Shi et al.
Lignin peroxidase (LiP) is a key enzyme involved in lignin degradation. However, the production of natural LiP is limited by the low enzyme-producing capacity of native fungal hosts and the poor stability of the enzyme, hindering its indust...
Combining biotechnology with sustainability: feasibility of bioenergy sorghum in generating high-value bioproducts [0.03%]
生物技术与可持续性的结合——能源高丹草生产高附加值产品的可行性研究
Trine B Andersen,Elliot Braun,Brianna N I Brown et al.
Trine B Andersen et al.
Biofuels generated through fermentation of plant-derived lignocellulosic biomass are currently not competitive with fossil fuels. Here, a framework is described for the engineering of valuable coproducts to improve the economic feasibility ...
Gene disruption via a transient hypercompact CRISPR-AsCas12f1 system in Kluyveromyces marxianus [0.03%]
基于瞬时超紧凑CRISPR-AsCas12f1系统的克鲁维酵母基因组编辑体系
Kehui Zhang,Dongmei Wang,Shenglin Hu et al.
Kehui Zhang et al.
Kluyveromyces marxianus is an attractive chassis for microbial cell factories due to its rapid growth, thermotolerance, and wide substrate spectrum. However, gene disruption in this organism is challenging primarily due the prevalence of do...