Safety evaluation and optimization of high-efficiency expression of 5hsCT in Saccharomyces cerevisiae [0.03%]
酿酒酵母高效表达5hsCT的安全性评价与优化研究
Yakun Zhang,Wenlu Jia,Wenli Qiu et al.
Yakun Zhang et al.
To evaluate the oral safety of the industrial strain Saccharomyces cerevisiae YS-5hsCT (S. cerevisiae YS-5hsCT) expressing human/salmon chimeric calcitonin (5hsCT) and optimize its fermentation conditions, providing scientific basis for ind...
Discovery of novel compound IGYZT01060 for inhibition of IRAK-4 enzyme for the treatment of sepsis [0.03%]
新型抗IRAK-4酶抑制剂IGYZT01060用于治疗脓毒症
Deepali Shrivastava,Lavleen K Gupta,Adinarayana Reddy Yerrapureddy et al.
Deepali Shrivastava et al.
Purpose: This study aimed at the discovery of a novel chemical entity, IGYZT01060 for inhibiting IRAK-4 (Interleukin-1 receptor-associated kinase 4) and testing its ability to inhibit the IRAK-4 enzyme, that is crucial in...
Identification of antifungal metabolites from a soil-derived Streptomyces strain active against Fusarium graminearum using genome mining [0.03%]
利用基因组挖掘鉴定一种土壤链霉菌菌株的抗真菌代谢物该代谢物对禾谷镰刀菌活性较高
Xingyu Liu,Lubna Rahman,Yang Zhang et al.
Xingyu Liu et al.
Microbes derived from soil environments are well-recognized as prolific producers of bioactive secondary metabolites, making significant contributions to the advancement of antibiotic research. In this study, we isolated a soil-derived Stre...
Expression of nisin in Scenedesmus acutus and evaluation of its antimicrobial activity [0.03%]
Nutraceut素尼斯汀在斜生栅藻中的表达及其抑菌活性评价icus and cosmetic properties of chitosan nanoparticles loaded with resveratrol from Polygonum cuspidatum roots
Julieta Ponce-Alonso,Luzmila Martínez-González,Ángel Gabriel Alpuche-Solís et al.
Julieta Ponce-Alonso et al.
Objectives: The study aimed to express a synthetic nisin gene in the nucleus of the green microalga Scenedesmus acutus UTEX 72 and evaluate its antimicrobial activity in vitro against Staphylococcus aureus (ATCC 29213), E...
Carrier immobilization and auto-exposition favoring reuse of silyletherase SilE-R from Brassica sp. with high activity and enantiospecificity [0.03%]
固载与自显露增强蔊菜硅醚酶SilE-R的重复使用及其高活性及对映体特异性
Lisa Pick,Anna L Schumacher,Elif Öztel et al.
Lisa Pick et al.
Objectives: Investigation of immobilization methods promoting the use of silyletherases from Brassica sp. for the efficient and enantiospecific hydrolysis of silyl-protected hydroxyl functions. ...
Heterologous expression of flavohemoglobin in Rhodotorula toruloides led to improved lipid production [0.03%]
异源表达类黄素血红蛋白可提高圆红冬孢酵母脂质产量
Shouping Lai,Liting Lyu,Aabid Manzoor Shah et al.
Shouping Lai et al.
The red yeast Rhodotorula toruloides emerged as a prominent host for microbial lipid production. It has been known that oxygen supply is a limiting factor for de novo lipid biosynthesis especially under high cell-density culture conditions....
Balamurugan Shanmugaraj,Kavin Ravi,Kishore Baladevan
Balamurugan Shanmugaraj
Orphan diseases comprise a range of disorders that individually affect a small percentage of people, but collectively impact millions of people worldwide. Patients with this disorder often face significant challenges in diagnosis, treatment...
Improvement of transglutaminase production by controlling the morphology of Streptomyces mobaraensis HVCP-Sm1 with microparticle-enhanced cultivation [0.03%]
采用微粒增效培养控制HVCP-Sm1产气节杆菌形态以提高谷氨酰胺转胺酶产量
Ting-Ting Chang,Lu-Yao Bian,Chong Zhang
Ting-Ting Chang
Objective: Transglutaminase (TGase) is widely utilized in food, textile, and medical applications due to its superior capacity to facilitate protein cross-linking. The mechanisms driving high TGase production in Streptomy...
Enhancing terpenoid production in Saccharomyces cerevisiae via cell morphology engineering [0.03%]
通过细胞形态工程增强酿酒酵母中倍半萜的生产
Ke Bi,Siqi Zuo,Jiazhang Lian et al.
Ke Bi et al.
There is a growing interest in establishing yeast as a cell factory for terpenoid production. Given the hydrophobicity of many terpenoids, expanding the intracellular storage pool is an effective strategy to improve titers. In this study, t...
Recent advances in microbial and bioelectrochemical strategies for degradation of per- and polyfluoroalkyl substances: mechanisms, limitations, and research opportunities [0.03%]
近期微生物和生物电化学策略降解全氟和多氟化合物的研究进展：机制、局限性及研究机遇
Haoran Yang,Jia Liu
Haoran Yang
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants characterized by strong carbon-fluorine bonds, making them resistant to conventional degradation methods. Their widespread detection in soil, water, and livi...