POLR3A mutations cause nucleolus abnormalities and aberrant telomerase RNA metabolism in induced pluripotent stem cells from Wiedemann-Rautenstrauch premature aging syndrome patient [0.03%]
POLR3A突变导致Wiedemann-Rautenstrauch早老综合征患者诱导多能干细胞中的核仁异常和端粒酶RNA代谢异常
Evgeniya A Orlova,Vepa K Abdyev,Valeriya Morgunova et al.
Evgeniya A Orlova et al.
Induced pluripotent stem cells (iPSCs) derived from patients with premature aging disorders are widely regarded as a foundation for both the study of fundamental aging mechanisms and preclinical testing of anti-aging therapies. The most wel...
Genetically predicted causal links between gut microbiota and biological aging phenotypes in age-related macular degeneration [0.03%]
遗传预测的肠道微生物组与年龄相关黄斑变性中生物学老化表型的因果关系
Yifan Zhou,Zhenyu Wang,Chen Huang et al.
Yifan Zhou et al.
Current knowledge regarding the role of gut microbiota (GM) dysbiosis and biological aging in the pathogenesis of age-related macular degeneration (AMD) remains limited. This study aims to explore the causal relationships among these factor...
Therapeutic extracellular vesicles as a cornerstone of medicine in the next decade with gerontological focus [0.03%]
治疗性细胞外囊泡作为下一个十年医学基础的抗衰老焦点疗法
Alexander Yu Pulver,Roman E Tokmachev,Natalie A Pulver et al.
Alexander Yu Pulver et al.
Extracellular vesicles present a promising alternative to stem cells in regenerative medicine and gerontology. They offer significant advantages over cell transplantation, demonstrating potential for slowing aging and treating age-related d...
12-ethoxy-Marchantin A, a new macrocyclic bis-bibenzyl from Marchantia polymorpha L., exerts anti-aging activity through activating MAPKs-dependent Nrf2/HO-1 signaling pathways [0.03%]
来自聚煤带地钱的全新大环二双苯乙烯类化合物12-乙氧基马氏素A通过激活MAPKs依赖型Nrf2/HO-1信号通路发挥抗衰老作用
Bingjian Wu,Ge Ge,Jiaxin Xu et al.
Bingjian Wu et al.
Phytochemicals represent emerging anti-aging therapeutic candidates, with Marchantia polymorpha L. (liverwort) gaining significant attention due to its broad-spectrum pharmacological properties. This plant exhibits remarkable wound-healing ...
Chrysin, a glycolytic inhibitor, modulates redox homeostasis during aging via a potent calorie restriction mimetic effect in male wistar rats [0.03%]
染料木素通过强大的模拟限制摄食作用调节雄性Wistar大鼠衰老过程中的氧化还原稳态
Akanksha Singh,Sakshi Jaiswal,Raushan Kumar et al.
Akanksha Singh et al.
Chrysin (5,7-dihydroxyflavone), a natural flavonoid present in honey, propolis, and various medicinal plants, has shown promise as a calorie restriction mimetic (CRM) through its glycolysis-inhibiting action. This inhibition promotes a meta...
Effects of low-intensity pulsed ultrasound on muscle mass and Fndc5 mRNA expression in aged male mice [0.03%]
低强度脉冲超声对老龄雄性小鼠肌肉质量和Fndc5基因表达的影响
Yoshitsugu Kojima
Yoshitsugu Kojima
Sarcopenia, the progressive loss of skeletal muscle mass and function with aging, is a growing public health concern. Conventional treatments such as exercise, pharmacological agents, and nutritional support offer limited efficacy, especial...
Unraveling the mysteries of Hutchinson-Gilford progeria syndrome: a comprehensive review of LMNA gene mutations [0.03%]
解密Hutchinson-Gilford早老症综合征：LMNA基因突变综述性研究
Xiaoqing Zhou,Jun Song
Xiaoqing Zhou
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare and fatal disorder characterized by premature aging, predominantly resulting from mutations in the LMNA gene, which lead to the accumulation of a truncated and aberrant progerin protein....
The impact of physical exercise on genotoxicity in older adults: a systematic review [0.03%]
体力锻炼对老年人遗传毒性的的影响：一项系统性综述
Thiago Guedes Pinto,Daniel Vitor de Souza,Katia De Angelis et al.
Thiago Guedes Pinto et al.
In the context of increasing life expectancy, a higher prevalence of age-related chronic diseases is becoming more common in the health landscape, many of which are closely linked to insufficient physical exercise during lifespan. On the ot...
Multifaceted dynamics of circadian timing system influence aging and longevity [0.03%]
昼夜节律时钟的多面体动力学影响衰老和长寿
Anita Jagota,Zeeshan Akhtar Khan,Sushree Abhidhatri Sharma et al.
Anita Jagota et al.
Circadian time keeping system (CTS) consisting of network of central and peripheral clocks regulates physiological, metabolic, and behavioural processes in alignment with the 24 hour. Desynchrony between central and peripheral clocks contri...
Correction: Realistic expectations for changes to average human lifespan in the near future [0.03%]
纠正：对未来人类平均寿命变化的现实预期
Adiv A Johnson
Adiv A Johnson
Published Erratum
Biogerontology. 2025 Sep 22;26(5):183. DOI:10.1007/s10522-025-10323-x 2025