Brinda Vallat,Benjamin Webb,John Westbrook et al.
Brinda Vallat et al.
Limitations in the applicability, accuracy, and precision of individual structure characterization methods can sometimes be overcome via an integrative modeling approach that relies on information from all available sources, including all a...
Brittney A Klein,Brian D Sykes
Brittney A Klein
Insights into the structure and dynamics of large biological systems has been greatly improved by two concurrent NMR approaches: the application of transverse relaxation-optimized spectroscopy (TROSY) techniques in multi-dimensional NMR, es...
A unified structural model of the mammalian translocator protein (TSPO) [0.03%]
哺乳动物转运定位蛋白(TSPO)的统一结构模型
Yan Xia,Kaitlyn Ledwitch,Georg Kuenze et al.
Yan Xia et al.
The translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), is a membrane protein located on the outer mitochondrial membrane. Experimentally-derived structures of mouse TSPO (mTSPO) and its homologs f...
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations [0.03%]
结合核磁共振与分子动力学模拟研究水合及抑制剂与HIV-1蛋白酶相互作用及其耐药突变的调节效应
Rieko Ishima,Nese Kurt Yilmaz,Celia A Schiffer
Rieko Ishima
Over the last two decades, both the sensitivity of NMR and the time scale of molecular dynamics (MD) simulation have increased tremendously and have advanced the field of protein dynamics. HIV-1 protease has been extensively studied using t...
I-PINE web server: an integrative probabilistic NMR assignment system for proteins [0.03%]
I-PINE网络服务器：蛋白质综合概率NMR assignments系统
Woonghee Lee,Arash Bahrami,Hesam T Dashti et al.
Woonghee Lee et al.
Various methods for understanding the structural and dynamic properties of proteins rely on the analysis of their NMR chemical shifts. These methods require the initial assignment of NMR signals to particular atoms in the sequence of the pr...
Solution structure of the N-terminal domain of the Staphylococcus aureus hibernation promoting factor [0.03%]
金黄色葡萄球菌休眠促进因子N末端结构域溶液结构
Konstantin S Usachev,Shamil Z Validov,Iskander Sh Khusainov et al.
Konstantin S Usachev et al.
Staphylococcus aureus hibernation promoting factor (SaHPF) is a 22,2 kDa protein which plays a crucial role in 100S Staphylococcus aureus ribosome formation during stress. SaHPF consists of N-terminal domain (NTD) that prevents proteins syn...
Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches [0.03%]
互补方法解析第二型分泌系统假菌毛的动态变化
Benjamin Bardiaux,Florence Cordier,Sébastien Brier et al.
Benjamin Bardiaux et al.
Secretion pili, bacterial fibers responsible for transporting proteins to the extracellular milieu in some secretion systems, are very strong structures but at the same time highly flexible. Their flexibility and helical symmetry make struc...
Accurate measurement of dipole/dipole transverse cross-correlated relaxation [Formula: see text] in methylenes and primary amines of uniformly [Formula: see text]-labeled proteins [0.03%]
均匀13C标记的蛋白质亚甲基和一级胺中的偶极/偶极横向交叉弛豫[公式见正文中英文原文][_formula: 看见正文中英文原文]的精确测量
Dmitry M Lesovoy,Maxim A Dubinnyi,Svetlana B Nolde et al.
Dmitry M Lesovoy et al.
Side chains possess a broader conformational space (compared to the backbone) and are directly affected by intra- and intermolecular interactions, hence their dynamics and the corresponding NMR relaxation data are more sensitive and informa...
NMRlib: user-friendly pulse sequence tools for Bruker NMR spectrometers [0.03%]
NMRlib：Bruker核磁共振谱仪的用户友好型脉冲序列工具
Adrien Favier,Bernhard Brutscher
Adrien Favier
We present NMRlib, a suite of jython-based tools designed for Bruker spectrometers (TopSpin versions 3.2-4.0) that allow easy setup, management, and exchange of NMR experiments. A NMR experiment can be set up and executed in a few clicks by...
Validation of protein backbone structures calculated from NMR angular restraints using Rosetta [0.03%]
通过Rosetta使用NMR角度限制验证计算的蛋白质主链结构
Joel Lapin,Alexander A Nevzorov
Joel Lapin
Multidimensional solid-state NMR spectra of oriented membrane proteins can be used to infer the backbone torsion angles and hence the overall protein fold by measuring dipolar couplings and chemical shift anisotropies, which depend on the o...