Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR [0.03%]
固体核磁共振研究人类线粒体膜蛋白VDAC2在脂质双层中的结构特征
Matthew T Eddy,Tsyr-Yan Yu,Gerhard Wagner et al.
Matthew T Eddy et al.
The second isoform of the human voltage dependent anion channel (VDAC2) is a mitochondrial porin that translocates calcium and other metabolites across the outer mitochondrial membrane. VDAC2 has been implicated in cardioprotection and play...
Importance of time-ordered non-uniform sampling of multi-dimensional NMR spectra of Aβ1-42 peptide under aggregating conditions [0.03%]
Aβ1-42肽聚集过程中多维核磁共振谱时间顺序非等间距采样重要性研究
Jinfa Ying,C Ashley Barnes,John M Louis et al.
Jinfa Ying et al.
Although the order of the time steps in which the non-uniform sampling (NUS) schedule is implemented when acquiring multi-dimensional NMR spectra is of limited importance when sample conditions remain unchanged over the course of the experi...
Assigning NMR spectra of RNA, peptides and small organic molecules using molecular network visualization software [0.03%]
基于分子网络可视化软件的RNA、多肽及小分子有机物核磁共振谱图分配研究
Jan Marchant,Michael F Summers,Bruce A Johnson
Jan Marchant
NMR assignment typically involves analysis of peaks across multiple NMR spectra. Chemical shifts of peaks are measured before being assigned to atoms using a variety of methods. These approaches quickly become complicated by overlap, ambigu...
Anne C Conibear,K Johan Rosengren,Christian F W Becker et al.
Anne C Conibear et al.
Most eukaryotic proteins are modified during and/or after translation, regulating their structure, function and localisation. The role of posttranslational modifications (PTMs) in both normal cellular processes and in diseases is already we...
Rob Kaptein,Gerhard Wagner
Rob Kaptein
NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins [0.03%]
利用核磁共振研究固有无序蛋白中的溶剂接触及瞬时结构
Christoph Hartlmüller,Emil Spreitzer,Christoph Göbl et al.
Christoph Hartlmüller et al.
In order to understand the conformational behavior of intrinsically disordered proteins (IDPs) and their biological interaction networks, the detection of residual structure and long-range interactions is required. However, the large number...
Reaching the sparse-sampling limit for reconstructing a single peak in a 2D NMR spectrum using iterated maps [0.03%]
迭代映射法重建二维核磁共振谱中单峰值的稀疏采样极限
Robert L Blum,Jared Rovny,J Patrick Loria et al.
Robert L Blum et al.
Many of the ubiquitous experiments of biomolecular NMR, including [Formula: see text], [Formula: see text], and CEST, involve acquiring repeated 2D spectra under slightly different conditions. Such experiments are amenable to acceleration u...
Using Deep Neural Networks to Reconstruct Non-uniformly Sampled NMR Spectra [0.03%]
基于深度神经网络的非均匀采样核磁共振谱重构技术
D Flemming Hansen
D Flemming Hansen
Non-uniform and sparse sampling of multi-dimensional NMR spectra has over the last decade become an important tool to allow for fast acquisition of multi-dimensional NMR spectra with high resolution. The success of non-uniform sampling NMR ...
CombLabel: rational design of optimized sequence-specific combinatorial labeling schemes. Application to backbone assignment of membrane proteins with low stability [0.03%]
结合标签：优化序列特异性组合标记方案的理性设计。应用于不稳定膜蛋白质质谱背骨赋值
M Yu Myshkin,M A Dubinnyi,D S Kulbatskii et al.
M Yu Myshkin et al.
Assignment of backbone resonances is a necessary initial step in every protein NMR investigation. Standard assignment procedure is based on the set of 3D triple-resonance (1H-13C-15N) spectra and requires at least several days of experiment...
Accelerating 2D NMR relaxation dispersion experiments using iterated maps [0.03%]
利用迭代映射加速二维NMR弛豫分散实验
Jared Rovny,Robert L Blum,J Patrick Loria et al.
Jared Rovny et al.
NMR relaxation dispersion experiments play a central role in exploring molecular motion over an important range of timescales, and are an example of a broader class of multidimensional NMR experiments that probe important biomolecules. Howe...