Correction to: The role of NMR in leveraging dynamics and entropy in drug design [0.03%]
校正：关于NMR在药物设计中发挥动力学和熵作用的研究
Abhinav Dubey,Koh Takeuchi,Mikhail Reibarkh et al.
Abhinav Dubey et al.
Unfortunately, in the original publication, Fig. 5 was published incorrectly. The correct version is given below.
Published Erratum
Journal of biomolecular NMR. 2020 Nov;74(10-11):499-500. DOI:10.1007/s10858-020-00342-w 2020
Dynamic 15N{1H} NOE measurements: a tool for studying protein dynamics [0.03%]
动态的15N{1H} NOE测量：研究蛋白质动力学的一种工具
Vladlena Kharchenko,Michal Nowakowski,Mariusz Jaremko et al.
Vladlena Kharchenko et al.
Intramolecular motions in proteins are one of the important factors that determine their biological activity and interactions with molecules of biological importance. Magnetic relaxation of 15N amide nuclei allows one to monitor motions of ...
Sébastien Keiffer,Marta G Carneiro,Johan Hollander et al.
Sébastien Keiffer et al.
No matter the source of compounds, drug discovery campaigns focused directly on the target are entirely dependent on a consistent stream of reliable data that reports on how a putative ligand interacts with the protein of interest. The data...
Raymond S Norton,Wolfgang Jahnke
Raymond S Norton
Parker J Nichols,Alexandra Born,Morkos A Henen et al.
Parker J Nichols et al.
We have previously reported on the measurement of exact NOEs (eNOEs), which yield a wealth of additional information in comparison to conventional NOEs. We have used these eNOEs in a variety of applications, including calculating high-resol...
NMR in integrated biophysical drug discovery for RAS: past, present, and future [0.03%]
RAS综合生物物理药物发现中NMR的应用：过去、现在和未来
Christopher B Marshall,Fenneke KleinJan,Teklab Gebregiworgis et al.
Christopher B Marshall et al.
Mutations in RAS oncogenes occur in ~ 30% of human cancers, with KRAS being the most frequently altered isoform. RAS proteins comprise a conserved GTPase domain and a C-terminal lipid-modified tail that is unique to each isoform. The GTPase...
Sensitive and simplified: a combinatorial acquisition of five distinct 2D constant-time 13C-1H NMR protein correlation spectra [0.03%]
灵敏且简化：五种不同的二维恒定时间13C-1H核磁共振蛋白质相关光谱的组合采集
Yuichi Yoshimura,Frans A A Mulder
Yuichi Yoshimura
A procedure is presented for the substantial simplification of 2D constant-time 13C-1H heteronuclear single-quantum correlation (HSQC) spectra of 13C-enriched proteins. In this approach, a single pulse sequence simultaneously records eight ...
Probing conformational transitions towards mutagenic Watson-Crick-like G·T mismatches using off-resonance sugar carbon R1ρ relaxation dispersion [0.03%]
利用非共振糖碳R1ρ弛豫色散探究向致突变的Watson-Crick-like G·T错配基序的构象转变
Atul Rangadurai,Eric S Szymanski,Isaac Kimsey et al.
Atul Rangadurai et al.
NMR off-resonance R1ρ relaxation dispersion measurements on base carbon and nitrogen nuclei have revealed that wobble G·T/U mismatches in DNA and RNA duplexes exist in dynamic equilibrium with short-lived, low-abundance, and mutagenic Wat...
NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide-dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei [0.03%]
核磁共振片段筛选揭示了伯克霍尔德菌DsbA半胱氨酸-二硫键氧化还原酶催化表面附近的新型小分子结合位点
Stefan Nebl,Wesam S Alwan,Martin L Williams et al.
Stefan Nebl et al.
The presence of suitable cavities or pockets on protein structures is a general criterion for a therapeutic target protein to be classified as 'druggable'. Many disease-related proteins that function solely through protein-protein interacti...
Abhinav Dubey,Koh Takeuchi,Mikhail Reibarkh et al.
Abhinav Dubey et al.
Nuclear magnetic resonance (NMR) spectroscopy has contributed to structure-based drug development (SBDD) in a unique way compared to the other biophysical methods. The potency of a ligand binding to a protein is dictated by the binding free...