Effect of CFTR modulators Elexacaftor/Tezacaftor/Ivacaftor on lipid metabolism in human bronchial epithelial cells [0.03%]
CFTR调节剂Elexacaftor/Tezacaftor/Ivacaftor对人支气管上皮细胞脂质代谢的影响
Dorina Dobi,Nicoletta Loberto,Laura Mauri et al.
Dorina Dobi et al.
Cystic Fibrosis (CF) is a life-threatening hereditary disease resulting from mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene that encodes a chloride channel essential for ion transport in epithelial cells. M...
SUMOylated GLUT1 inhibited the glycometabolism disorder in chondroctyes during osteoarthritis [0.03%]
SUMO化GLUT1可抑制软骨细胞终板软骨在骨关节炎中的糖代谢紊乱
Liwei Xiong
Liwei Xiong
Reduction of glucose transporter 1 (GLUT1), even deletion, may results in cartilage fibrosis and osteoarthritis. This study aims to investigate the SUMOylation of GLUT1 in osteoarthritis through small ubiquitin-like modifier 1(SUMO1), and e...
MUC1 expression is associated with ST3GAL2 and negatively correlated with the androgen receptor in castration-resistant prostate cancer [0.03%]
ST3GAL2与MUC1表达相关，并且后者的表达与雄激素受体在去势抵抗性前列腺癌中呈负相关
Shotaro Nakanishi,Tetsuji Suda,Kei Tanaka et al.
Shotaro Nakanishi et al.
Stage-specific embryonic antigen-4 (SSEA-4) is a developmentally regulated antigen, while expression level of SSEA-4 and / or its synthase ST3GAL2 is associated with prognosis in various malignancies. We have reported a prominent increase o...
Inhibition of sulfated glycans on the binding of dengue virus envelope protein to heparin [0.03%]
硫酸化糖类对登革病毒包膜蛋白与肝素结合的抑制作用
Jiyuan Yang,Payel Datta,Ke Xia et al.
Jiyuan Yang et al.
Dengue viruses (DENV) are transmitted to humans through mosquito bites and infect millions globally. DENV uses heparan sulfate (HS) for attachment and cell entry by binding the envelope protein to highly sulfated HS on target cells. Therefo...
Processing of N-glycans in the ER and Golgi influences the production of surface sialylated glycoRNA [0.03%]
内质网和高尔基体中N-聚糖的加工影响表面岩藻糖基化甘露糖苷RNA的产生
Yi-Shi Liu,Yu-Long Miao,Yue Dou et al.
Yi-Shi Liu et al.
Glycoconjugates, including glycans on proteins and lipids, have obtained significant attention due to their critical roles in both intracellular and intercellular biological functions and processes. Notably, recent discoveries have revealed...
Correction: Production of Domain 9 from the cation-independent mannose-6-phosphate receptor fused with an Fc domain [0.03%]
纠正：与Fc结构域融合的独立于阳离子的甘露糖-6-磷酸受体的第9结构城的生成
Yu-He Tang,Yi-Shi Liu,Morihisa Fujita
Yu-He Tang
Published Erratum
Glycoconjugate journal. 2024 Nov 4. DOI:10.1007/s10719-024-10170-x 2024
Production of Domain 9 from the cation-independent mannose-6-phosphate receptor fused with an Fc domain [0.03%]
带有Fc结构域的阳离子独立型甘露糖-6-磷酸受体第9结构城的产生
Yu-He Tang,Yi-Shi Liu,Morihisa Fujita
Yu-He Tang
Lysosomal storage diseases (LSDs) are genetic disorders caused by mutations in lysosomal enzymes, lysosomal membrane proteins or genes related to intracellular transport that result in impaired lysosomal function. Currently, the primary tre...
Emerging role of MAPK signaling in glycosphingolipid-associated tumorigenesis [0.03%]
MAPK信号在糖脂相关肿瘤发生中的作用不容小觑
Elora Khamrui,Sounak Banerjee,Dipanwita Das Mukherjee et al.
Elora Khamrui et al.
Glycosphingolipids (GSLs) are a type of amphipathic lipid molecules consisting of hydrophobic ceramide backbone bound to carbohydrate moiety clustered in the cell surface microdomains named 'lipid rafts' and are known to participate in cell...
RACK1 inhibits ferroptosis of cervical cancer by enhancing SLC7A11 core-fucosylation [0.03%]
RACK1通过增强SLC7A11核心岩藻糖基化抑制宫颈癌铁死亡
Anqi Yan,Hao Wu,Wei Jiang
Anqi Yan
Receiver for Activated C Kinase 1 (RACK1) is a highly conserved scaffold protein that can assemble multiple kinases and proteins together to form complexes, thereby regulating signal transduction process and various cellular biological proc...
Site-directed mutagenesis leads to the optimized transglycosylation activity of endo-beta-N-acetylglucosaminidase from Trypanosoma brucei [0.03%]
针对特异突变优化布氏冈比亚斯眠虫内切-β-N-乙酰氨基葡萄糖苷酶的转糖基作用活性
Yi Ding,Zheng-Hui Chen,Juan Cui et al.
Yi Ding et al.
Endo-β-N-acetylglucosaminidases (ENGases) are pivotal enzymes in the degradation and remodeling of glycoproteins, which catalyze the cleavage or formation of β-1,4-glycosidic bond between two N-acetylglucosamine (GlcNAc) residues in N-lin...