Masanori Yamaguchi,Kenji Yamamoto
Masanori Yamaguchi
The human intestinal tract is inhabited by a tremendous number of microorganisms, which are collectively termed "the gut microbiota". The intestinal epithelium is covered with a dense layer of mucus that prevents penetration of the gut micr...
The generation of 5-N-glycolylneuraminic acid as a consequence of high levels of reactive oxygen species [0.03%]
高水平反应氧簇生成5-N-甘油神经氨酸酸的现象研究
Ruifeng Bai,Jingyi Wang,Inka Brockhausen et al.
Ruifeng Bai et al.
The presence of N-glycolylneuraminic acid (Neu5Gc), a non-human sialic acid in cancer patients, is currently attributed to the consumption of red meat. Excess dietary red meat has been considered a risk factor causing chronic inflammation a...
Recognition factors of Dolichos biflorus agglutinin (DBA) and their accommodation sites [0.03%]
刀豆蛋白A的识别分子及其结合部位
Albert M Wu,Anna Dudek,Yung Liang Chen
Albert M Wu
Dolichos biflorus agglutinin (DBA) is one of the well known plant lectins that are widely used in clinical serology to differentiate human blood group A1 and A2 erythrocytes and also applied to glycobiology. However, the knowledge of recogn...
Interactions between polysialic acid and dopamine-lead compounds as revealed by biochemical and in silico docking simulation analyses [0.03%]
多唾液酸与多巴胺-先导化合物的相互作用及生化和分子对接模拟分析揭示了这一点
Kaito Hayakawa,Masaya Hane,Hiroki Hamagami et al.
Kaito Hayakawa et al.
Polysialic acid is an important glyco-epitope in vertebrate brains, while altered expressions of polySia and biosynthetic enzyme have been reported in brain diseases such as schizophrenia and depression. Recently, the binding between polySi...
The vertebrate sialylation machinery: structure-function and molecular evolution of GT-29 sialyltransferases [0.03%]
脊椎动物岩藻糖基化修饰体系：GT-29唾液酸转移酶的结构功能及其分子进化研究
Anne Harduin-Lepers
Anne Harduin-Lepers
Every eukaryotic cell is covered with a thick layer of complex carbohydrates with essential roles in their social life. In Deuterostoma, sialic acids present at the outermost positions of glycans of glycoconjugates are known to be key playe...
Straightforward synthesis of the hexasaccharide repeating unit of the O-specific polysaccharide of Salmonella arizonae O62 [0.03%]
夏氏Arizona O62血清型O特异多糖六糖重复单元的简洁合成法研究
Abhijit Rana,Pradip Shit,Anup Kumar Misra
Abhijit Rana
A straightforward synthesis of the hexasaccharide repeating unit of the O-specific polysaccharide of Salmonella arizonae O62 was achieved in very good yield applying sequential glycosylation strategy. Successful regioselective glycosylation...
Lina Gretenkort,Hauke Thiesler,Herbert Hildebrandt
Lina Gretenkort
Polymeric sialic acid (polysialic acid, polySia) is a remarkable posttranslational modification of only few select proteins. The major, and most prominent polySia protein carrier is the neural cell adhesion molecule NCAM. Here, the key func...
Recently developed glycosphingolipid probes and their dynamic behavior in cell plasma membranes as revealed by single-molecule imaging [0.03%]
recently developed glycosphingolipid探针及其在细胞质膜中的动态行为（基于单分子成像）
Kenichi G N Suzuki,Naoko Komura,Hiromune Ando
Kenichi G N Suzuki
Glycosphingolipids, including gangliosides, are representative lipid raft markers that perform a variety of physiological roles in cell membranes. However, studies aimed at revealing their dynamic behavior in living cells are rare, mostly d...
Advances in protein glycosylation and its role in tissue repair and regeneration [0.03%]
蛋白质糖基化研究进展及其在组织修复和再生中的作用
Zhongyu Yue,Yajie Yu,Boyuan Gao et al.
Zhongyu Yue et al.
After tissue damage, a series of molecular and cellular events are initiated to promote tissue repair and regeneration to restore its original structure and function. These events include inter-cell communication, cell proliferation, cell m...
Analysis of the intramolecular 1,7-lactone of N-acetylneuraminic acid using HPLC-MS: relationship between detection and stability [0.03%]
高效液相色谱质谱分析N-乙酰神经氨酸内酯的研究及检测与稳定性的关系研究
Paolo La Rocca,Ivana Lavota,Marco Piccoli et al.
Paolo La Rocca et al.
A subclass of the sialic acid family consists of intramolecular lactones that may function as key indicators of physiological and pathological states. However, the existence of these compounds in free form is highly improbable, since they a...