Protective role of ginger nanoparticles against hepatocellular carcinoma through regulation of DNA methylation and miRNA-34a-mediated apoptosis [0.03%]
姜黄纳米颗粒通过调节DNA甲基化和miRNA-34a介导的细胞凋亡来预防肝细胞癌的作用
Noha Nabil Mohamed,Samy Ali Hussein,Yakout Abdelfatah El-Senosi et al.
Noha Nabil Mohamed et al.
Background: Hepatocellular carcinoma (HCC) is a common, aggressive, and potentially fatal malignancy. Ginger possesses a wide range of beneficial biological effects on different body organs. The present study investigated...
Neutrophil extracellular traps in osteoporosis: mechanistic links to bone remodeling imbalance and therapeutic perspectives [0.03%]
中性粒细胞胞外陷阱与骨代谢失衡的关联及在治疗中的应用前景：机制联系及治疗学观点
Jun Yuan,Fengjiang Li,Jingwen Chen et al.
Jun Yuan et al.
Background: Osteoporosis (OP) is increasingly recognized as a disorder driven not only by endocrine and metabolic abnormalities but also by chronic low-grade inflammation and aging-related immune dysregulation. Neutrophil...
Estrogen replacement restores renal function and water homeostasis in ovariectomized rats: role of AQP2 and oxidative stress [0.03%]
雌激素替代恢复卵巢切除大鼠肾功能和水代谢：AQP2和氧化应激的作用
Yara A Ali,Amal M El-Nahla,Adel Abdel Hameed Siam et al.
Yara A Ali et al.
Background: Estrogen deficiency is associated with renal dysfunction, oxidative stress, and impaired water homeostasis. This study evaluated the renoprotective effects of estradiol benzoate (EB) on renal function, oxidati...
Ebastine mitigates cisplatin-induced pulmonary injury associated with alterations in the miR-101/PI3K/mTOR/ULK1 signaling axis [0.03%]
埃巴司丁通过调控miR-101/PI3K/mTOR/ULK1信号轴改变减轻顺铂诱导的肺损伤
Nayef A Aldabaan,Basel A Abdel-Wahab,Ehab A M El-Shoura et al.
Nayef A Aldabaan et al.
Background: Ebastine (EBT), a second-generation antihistamine, exhibits notable antioxidant and anti-inflammatory effects. EBT may serve as a promising therapeutic candidate for limiting drug-induced lung injury. This stu...
Synergistic inhibitory effects of combined liposomal formulations of caffeic acid phenethyl ester and vitamin D on melanoma cell proliferation [0.03%]
咖啡酸苯乙酯和维生素D联合脂质体配方对黑色素瘤细胞增殖的协同抑制作用
Azita Bahrami,Leila Zolghadr,Alireza Farasat et al.
Azita Bahrami et al.
Background: caffeic acid phenethyl ester (CAPE) and vitamin D inhibit melanoma growth through various anti-tumor mechanisms. The study investigated the impact of a 1:1 molar ratio of CAPE/vitamin D, both in free and lipos...
Antibiofilm and antivirulence effects of cinnamaldehyde on Acinetobacter baumannii [0.03%]
肉桂醛对醋酸钙不动杆菌生物被膜和毒力的影响
Thahiya Naushad,Sajna Salim,Shiburaj Sugathan et al.
Thahiya Naushad et al.
Background: Acinetobacter baumannii is a multidrug-resistant pathogen known for its robust biofilm formation, leading to persistent infections and treatment failure. Traditional antibiotics often struggle to penetrate the...
Neupogen/MSCs conditioned media inhibit HEp-2 laryngeal cancer cells proliferation by down regulating miRNA 21expression and ROS production [0.03%]
粒细胞集落刺激因子和间充质干细胞条件培养基通过下调miRNA 21表达及减少ROS的产生抑制HEp-2喉癌细胞增殖
Abeer Mostafa,Heba M Amr,Naglaa F Abozeid et al.
Abeer Mostafa et al.
Background: The process of cancer progression is maintained through a feedback loop whereby reactive oxygen species (ROS) induce inflammatory cytokines, which activate STAT3 and result in miRNA-21 upregulation. miRNA-21 e...
Advancing engineered nanoparticles for enhanced efficacy in cancer immunotherapy: optimizing nanoparticles for cancer immunotherapy [0.03%]
用于癌症免疫治疗的工程纳米颗粒的研发及功效增强：优化纳米颗粒以用于癌症免疫治疗
Mukta Basu,Elizabeth Mahapatra,Deepika Rai et al.
Mukta Basu et al.
Recent evidence on resistance to immune checkpoint inhibitors (ICIs) has necessitated the exploration of alternative cancer therapies with increased treatment responsiveness among patients, especially for solid tumors. Phototherapy with red...
Mechanism of sinomenine-induced apoptosis of human liver cancer cells via GRP78 membrane translocation [0.03%]
白屈菜红碱诱导人肝癌细胞凋亡的GRP78易位机制研究
Miao Yu,Yingjie Liu,Ying Xu et al.
Miao Yu et al.
Background: Sinomenine (SIN), the main active ingredient of Sinomenium acutum (Thunb.) Rehd. et Wils. Rhizomes, exhibits sensitive pharmacological activity against liver cancer. To elucidate the underlying mechanism, in v...
Advances in biomarkers for differential diagnosis of autoimmune and autoinflammatory inner ear disorders [0.03%]
自身免疫性和自身炎症性内耳疾病鉴别诊断生物标志物的研究进展
Shabnam Eskandarzadeh,Roghaye Faraji Akhijahani,Masoud Lahouty
Shabnam Eskandarzadeh
Autoimmune inner ear disease (AIED) represents a rare yet potentially reversible cause of sensorineural hearing loss, characterized by immune-mediated damage to cochlear and vestibular structures. Unlike autoimmunity, which is driven by ada...