Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway [0.03%]
埃里亚宁通过激活PI3K/Akt途径诱导三阴性乳腺癌细胞凋亡
Yonggang Xu,Rong Fang,Jie Shao et al.
Yonggang Xu et al.
Background: Triple-negative breast cancer (TNBC) is a refractory subtype of breast cancer, 25-30% of which have dysregulation in the PI3K/AKT pathway. The present study investigated the anticancer effect of erianin on TNB...
Gualou Xiebai Banxia decoction ameliorates Poloxamer 407-induced hyperlipidemia [0.03%]
瓜蒌薤白半夏汤对聚氧乙烯硫酸钠所致高脂血症大鼠的影响
Mingzhu Luo,Rong Fan,Xiaoming Wang et al.
Mingzhu Luo et al.
Ethnopharmacological relevance: Gualou Xiebai Banxia (GLXBBX) decoction is a well-known traditional Chinese herbal formula that was first discussed in the Synopsis of the Golden Chamber by Zhang Zhongjing in the Eastern H...
FOXD1 is a prognostic biomarker and correlated with macrophages infiltration in head and neck squamous cell carcinoma [0.03%]
FOXD1是头颈鳞癌预后生物标志物并与巨噬细胞浸润相关
Huazhen Liang,Chunning Zhang,Chaoming Li et al.
Huazhen Liang et al.
Background: Forkhead Box D1 (FOXD1) is differentially expressed in various tumors. However, its role and correlation with immune cell infiltration remains uncertain in head and neck squamous cell carcinoma (HNSC). ...
Identification of m6A methyltransferase-related lncRNA signature for predicting immunotherapy and prognosis in patients with hepatocellular carcinoma [0.03%]
识别与免疫治疗和肝细胞癌患者预后相关的m6A甲基转移酶相关长链非编码RNA特征标志物
Lili Li,Rongrong Xie,Guangrong Lu
Lili Li
N6-methyladenosine (m6A) methyltransferase has been shown to be an oncogene in a variety of cancers. Nevertheless, the relationship between the long non-coding RNAs (lncRNAs) and hepatocellular carcinoma (HCC) remains elusive. We integrated...
RAGE-mediated functional DNA methylated modification contributes to cigarette smoke-induced airway inflammation in mice [0.03%]
RAGE介导的DNA甲基化修饰参与了烟雾吸入诱导的小鼠气道炎症反应
Ping Li,Tao Wang,Mei Chen et al.
Ping Li et al.
Our previous study indicated knockout of receptor for advanced glycation end-products (RAGE) significantly attenuated cigarette smoke (CS)-induced airway inflammation in mice. In the present study, we aim to further detect the mediatory eff...
Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases [0.03%]
基于TCGA和GEO数据库的肺腺癌潜在诊断和预后生物标志物识别
Qiangqiang Zheng,Shihui Min,Qinghua Zhou
Qiangqiang Zheng
Accumulating evidence has demonstrated that gene alterations play a crucial role in LUAD development, progression, and prognosis. The present study aimed to identify the hub genes associated with LUAD. In the present study, we used TCGA dat...
The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis [0.03%]
姜黄提取物和姜黄素补充剂对骨关节炎的疗效和安全性：系统评价和 Meta 分析
Liuting Zeng,Ganpeng Yu,Wensa Hao et al.
Liuting Zeng et al.
Objective: To assess the efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis (OA). Methods: The dat...
Meta-Analysis
Bioscience reports. 2021 Jun 25;41(6):BSR20210817. DOI:10.1042/BSR20210817 2021
The selective alpha7 nicotinic acetylcholine receptor agonist AR-R17779 does not affect ischemia-reperfusion brain injury in mice [0.03%]
选择性α7烟碱型乙酰胆碱受体激动剂AR-R17779对小鼠缺血再灌注脑损伤无影响
Maria E Hammarlund,Vladimer Darsalia,Filip Mjörnstedt et al.
Maria E Hammarlund et al.
Inflammation plays a central role in stroke-induced brain injury. The alpha7 nicotinic acetylcholine receptor (α7nAChR) can modulate immune responses in both the periphery and the brain. The aims of the present study were to investigate α...
High glucose-induced Smad3 linker phosphorylation and CCN2 expression are inhibited by dapagliflozin in a diabetic tubule epithelial cell model [0.03%]
达格列净通过抑制糖尿病肾小管上皮细胞模型中的Smad3连接区磷酸化和CCN2表达发挥抗纤维化作用
Xinlu Pan,Mysore K Phanish,Deborah L Baines et al.
Xinlu Pan et al.
Background: In the kidney glucose is freely filtered by the glomerulus and, mainly, reabsorbed by sodium glucose cotransporter 2 (SGLT2) expressed in the early proximal tubule. Human proximal tubule epithelial cells (PTEC...
Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver-α-cell axis [0.03%]
小鼠GCGR基因有害突变V369M造成异常血浆氨基酸水平提示可能存在肝-α细胞轴
Qiaofeng Liu,Guangyao Lin,Yan Chen et al.
Qiaofeng Liu et al.
Glucagon plays an important role in glucose homeostasis and amino acid metabolism. It regulates plasma amino acid levels which in turn modulate glucagon secretion from the pancreatic α-cell, thereby establishing a liver-α-cell axis descri...