Dietary eggshell membrane modulates gut microbiota and alleviates AOM/DSS-induced colonic inflammation in mice [0.03%]
蛋壳膜调节肠道菌群并缓解小鼠AOM/DSS诱导的结肠炎
Wenqiang Yin,Sihui Ma,Maki Igarashi et al.
Wenqiang Yin et al.
Persistent intestinal inflammation and gut dysbiosis are key drivers of the progression from inflammatory bowel disease (IBD) to colitis-associated colorectal cancer (CAC). Eggshell membrane (ESM) has shown beneficial effects in alleviating...
Circulating tumor cells and circulating tumor microemboli: role in venous thromboembolism in oncologic patients [0.03%]
循环肿瘤细胞和循环微栓子在肿瘤患者静脉血栓栓塞中的作用
Anna Paula Carreta Ruano,Jacqueline Aparecida Torres,Ludmilla Thomé Domingos Chinen
Anna Paula Carreta Ruano
Venous thromboembolism (VTE) is one of the most frequent and serious complications in cancer patients, contributing significantly to morbidity, mortality, and increased healthcare burden. Circulating tumor cells (CTCs) and circulating tumor...
The human DDX52 protein is a nucleic acid helicase and strand annealase that promotes cell migration [0.03%]
人类DDX52蛋白是一种核酸解旋酶和链退火酶，可促进细胞迁移
Ashley J Parkes,Philipp J Springer,Edward Bolt
Ashley J Parkes
DExD-box (DDX) proteins are essential for RNA metabolism and are targets for treatment of cancers and neurodevelopmental disorders. The biochemical mechanisms of many DDX proteins remain unclear, including human DDX52. DDX52 is essential fo...
Homocysteine thiolactone affects paraoxonase 1 activity via altered paraoxonase 1 distribution on high-density lipoprotein particles [0.03%]
同型半胱氨酸硫内酯通过改变高密度脂蛋白颗粒上卵磷脂胆固醇酰基转移酶的分布来影响卵磷脂胆固醇酰基转移酶的活性
Rina Kawaguchi,Tsunehiro Miyakoshi,Akira Yoshimoto PhD et al.
Rina Kawaguchi et al.
Hyperhomocysteinemia is a risk factor of cardiovascular disease (CVD). High-density lipoprotein (HDL) plays an important role in anti-atherosclerosis, with its anti-atherogenic function attributed to HDL-associated proteins such as apolipop...
Serial measurement of circulating cardiovascular-enriched microRNAs in patients with ischaemic heart disease - a five-year longitudinal study [0.03%]
缺血性心脏病患者心血管特异性循环microRNA五年纵向队列研究
Jayanthi Bellae Papannarao,Sean Coffey,Andrew Gray et al.
Jayanthi Bellae Papannarao et al.
Patients with ischaemic heart disease (IHD) require frequent monitoring, as the transition from stable disease to acute life-threatening events remains largely unpredictable. MicroRNAs (miRNAs), small non-coding RNAs involved in physiologic...
Design, Synthesis, and Anticancer Activity of Novel Isocryptolepine "Aza" Type Acyl Thiourea Derivatives via Combined Experimental and Computational Approach [0.03%]
基于实验和计算相结合方法设计合成新型异隐品碱“Aza”型酰硫脲衍生物及其抗肿瘤活性研究
Ammara Fayyaz,Syeda Abida Ejaz,Atteeque Ahmed et al.
Ammara Fayyaz et al.
To identify novel tyrosinase inhibitors, a series of isocryptolepine "aza" type acyl thiourea analogs (6a-6h) were designed and synthesized using a multistep strategy. Spectroscopic methods including FTIR, UV-vis, 1H NMR, 13C NMR, and EI-MS...
Serum proteomics mirrors the histopathological changes underlying different etiologies of primary mitral valve disease [0.03%]
血清蛋白质组学反映了不同病因原发性二尖瓣疾病病理生理变化
Amaia Garcia-Peña,Jaime Ibarrola,Marina Segur et al.
Amaia Garcia-Peña et al.
Mitral valve disease (MVD) is the most common valvulopathy and a frequent cause of heart failure and death. However, data regarding molecular basis are scarce. We aimed to thoroughly explore and compare the circulating, molecular and histop...
Myocardial stunning: mechanisms, molecular insights, and gaps in knowledge [0.03%]
心肌休克：机制、分子见解和知识空白
Amin Al-Awar,Abdul Waheed Khan,Shafaat Hussain
Amin Al-Awar
Myocardial stunning, characterized by transient post-ischemic contractile dysfunction despite the restoration of coronary blood flow, has been a pivotal subject of cardiovascular research. Initially perceived as a consequence of irreversibl...
miRNAs as potential biomarkers for early detection of prediabetes among obesity: a systematic review [0.03%]
肥胖人群前驱糖尿病早期诊断潜在生物标志物miRNA系统评价
Brenda Wen Keng-Lim,Kelvin Yee Chen-Ng,Jia Yee-Lee et al.
Brenda Wen Keng-Lim et al.
Background: Prediabetes in individuals with obesity is a high-risk state for progression to type 2 diabetes mellitus (T2DM). Circulating microRNAs (miRNAs) have emerged as promising minimally invasive biomarkers for early...