Digoxin exerts anticancer activity on human nonsmall cell lung cancer cells by blocking PI3K/Akt pathway [0.03%]
地高辛通过阻断PI3K / Akt通路对人非小细胞肺癌细胞具有抗癌活性
Yingying Wang,Yongqiang Hou,Lanjiao Hou et al.
Yingying Wang et al.
Lung cancer remains the leading cause of cancer mortality because of its metastatic potential and high malignancy. The discovery of new applications for old drugs is a shortcut for cancer therapy. We recently investigated the antitumor effe...
Tissue-based metabolomics reveals metabolic signatures and major metabolic pathways of gastric cancer with help of transcriptomic data from TCGA [0.03%]
基于组织的代谢组学揭示了胃癌的代谢特征和主要代谢途径，并借助TCGA的转录组数据
Yaqin Wang,Wenchao Chen,Kun Li et al.
Yaqin Wang et al.
Purpose: The aim of the present study was to screen differential metabolites of gastric cancer (GC) and identify the key metabolic pathways of GC. Methods...
Glucosinolate biosynthesis: role of MAM synthase and its perspectives [0.03%]
葡萄糖硫苷生物合成：MAM 合成酶的作用及其前景
Bidyadhar Das
Bidyadhar Das
Glucosinolates, synthesized by the glucosinolate biosynthesis pathway, are the secondary metabolites used as a defence mechanism in the Brassicaceae plants, including Arabidopsis thaliana. The first committed step in the pathway, catalysed ...
Identification of potential genes related to breast cancer brain metastasis in breast cancer patients [0.03%]
乳腺癌脑转移相关潜在基因的识别在乳腺癌患者中
Lijian Zhang,Luxuan Wang,Hua Yang et al.
Lijian Zhang et al.
Brain metastases (BMs) usually develop in breast cancer (BC) patients. Thus, the molecular mechanisms of breast cancer brain metastasis (BCBM) are of great importance in designing therapeutic strategies to treat or prevent BCBM. The present...
USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer [0.03%]
USP52通过稳定非小细胞肺癌中的PTEN蛋白来抑制细胞增殖
Maoshu Zhu,Hui Zhang,Fuhua Lu et al.
Maoshu Zhu et al.
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer. Ubiquitination is closely related to the development of lung cancer. However, the biological importance of newly discovered ubiquitin-specific peptidase (USP) 52 ...
Exploring the mechanism of Danggui Buxue Decoction in regulating atherosclerotic disease network based on integrated pharmacological methods [0.03%]
基于整合药理学方法探究当归补血汤调节动脉粥样硬化疾病网络的机制
Hao Xu,Tianqing Zhang,Ling He et al.
Hao Xu et al.
Objective: To explore the mechanism of Danggui Buxue Decoction (DGBXD) in regulating Atherosclerosis (AS) network based on integrated pharmacological methods. ...
Establishment of non-small-cell lung cancer risk prediction model based on prognosis-associated ADME genes [0.03%]
基于与预后相关的ADME基因的非小细胞肺癌风险预测模型的建立
Ke Han,Jukun Wang,Kun Qian et al.
Ke Han et al.
Purpose: ADME genes are those involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs. In the present study, a non-small-cell lung cancer (NSCLC) risk prediction model was established using pro...
Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice [0.03%]
褪黑激素预防经表皮致敏小鼠的过敏性气道炎症
Xudong Liu,Yuchao Zhang,Yaolin Ren et al.
Xudong Liu et al.
Purpose: The pathological process of atopic dermatitis (AD) progressing into other types of allergic diseases such as asthma and allergic rhinitis during the first several years of life is often referred to as the atopic ...
Targeting intra-viral conserved nucleocapsid (N) proteins as novel vaccines against SARS-CoVs [0.03%]
靶向针对冠状病毒内的保守核衣壳(N)蛋白作为SARS冠状病毒的新型疫苗
Min Thura,Joel Xuan En Sng,Koon Hwee Ang et al.
Min Thura et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global pandemic of the Coronavirus disease in late 2019 (COVID-19). Vaccine development efforts have predominantly been aimed at 'Extra-viral' Spike (S) protein as ...
Detection of Campylobacter jejuni and Salmonella typhimurium in chicken using PCR for virulence factor hipO and invA genes (Saudi Arabia) [0.03%]
使用PCR检测鸡体内的空肠弯曲菌和鼠伤寒沙门氏菌的毒力因子基因hipO和invA（沙特阿拉伯）
Khaloud M Alarjani,Manal F Elkhadragy,Abdulrahman H Al-Masoud et al.
Khaloud M Alarjani et al.
Campylobacter jejuni and Salmonella typhimurium are the leading causes of bacterial food contamination in chicken carcasses. Contamination is particularly associated with the slaughtering process. The present study isolated C. jejuni and S....