Flavia L Martins,Caio A M Tavares,Pamella A Malagrino et al.
Flavia L Martins et al.
The angiotensin-converting enzyme (ACE)/Angiotensin II (Ang II) and angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) (Ang-(1-7)) pathways are coexpressed in most tissues. The balance between these pathways determines, at least in pa...
Effect of rs4646994 polymorphism of angiotensin-converting enzyme on the risk of nonischemic cardiomyopathy [0.03%]
血管紧张素转换酶rs4646994多态性对非缺血性心肌病发病风险的影响
Jinsheng Shen,Xuesong Qian,Xiaofei Mei et al.
Jinsheng Shen et al.
Background: Angiotensin-converting enzyme (ACE) gene polymorphisms have recently been shown to be associated with risk of developing left ventricular hypertrophy (LVH). However, the results were controversial. We aimed to...
Meta-Analysis
Bioscience reports. 2021 Dec 22;41(12):BSR20211617. DOI:10.1042/BSR20211617 2021
Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP [0.03%]
利用GPI锚生物合成基因PIGP对人类细胞系中的靶向敲入事件进行流式细胞仪定量分析
Md Lutfur Rahman,Toshinori Hyodo,Muhammad Nazmul Hasan et al.
Md Lutfur Rahman et al.
Targeted knock-in supported by the CRISPR/Cas systems enables the insertion, deletion, and substitution of genome sequences exactly as designed. Although this technology is considered to have wide range of applications in life sciences, one...
Real-time kinetic studies of Mycobacterium tuberculosis LexA-DNA interaction [0.03%]
结核分枝杆菌LexA-DNA相互作用的实时动力学研究
Chitral Chatterjee,Soneya Majumdar,Sachin Deshpande et al.
Chitral Chatterjee et al.
Transcriptional repressor, LexA, regulates the "SOS" response, an indispensable bacterial DNA damage repair machinery. Compared to its E.coli ortholog, LexA from Mycobacterium tuberculosis (Mtb) possesses a unique N-terminal extension of ad...
Exosomal miR-150 partially attenuated acute lung injury by mediating microvascular endothelial cells and MAPK pathway [0.03%]
外泌体miR-150通过介导微血管内皮细胞和MAPK通路部分减轻急性肺损伤
Jiaxin Xu,Dan Xu,Zhizhong Yu et al.
Jiaxin Xu et al.
Background: Acute lung injury (ALI) is a respiratory disease with high morbidity and mortality rates. Currently, there is no effective treatment to complement mechanical ventilation. Exosomes and microRNAs (miRNAs) are pr...
Detection of subtype-specific breast cancer surface protein biomarkers via a novel transcriptomics approach [0.03%]
通过新型转录组学方法检测特定亚型的乳腺癌表面蛋白生物标志物
Daniele Mercatelli,Francesco Formaggio,Marco Caprini et al.
Daniele Mercatelli et al.
Background: Cell-surface proteins have been widely used as diagnostic and prognostic markers in cancer research and as targets for the development of anticancer agents. So far, very few attempts have been made to characte...
High-dose dexamethasone injection disordered metabolism and multiple protein kinases expression in the mouse kidney [0.03%]
大剂量地塞米松注射引起小鼠肾脏代谢紊乱及多种蛋白激酶表达异常的研究
Zaikuan Zhang,Yingchun Ran,Lei Xu et al.
Zaikuan Zhang et al.
Glucocorticoids (GCs) have been widely used in clinical treatment as anti-inflammatory, anti-shock and immunosuppressive medicines. However, the effect of excessive GCs on immune response and metabolism of kidney remains unclear. Here, we p...
Olga Villamar-Cruz,Marco A Loza-Mejía,Luis E Arias-Romero et al.
Olga Villamar-Cruz et al.
Protein tyrosine phosphorylation is one of the major post-translational modifications in eukaryotic cells and represents a critical regulatory mechanism of a wide variety of signaling pathways. Aberrant protein tyrosine phosphorylation has ...
Ferroptosis-related gene signature correlates with the tumor immune features and predicts the prognosis of glioma patients [0.03%]
与铁死亡相关基因特征相关的肿瘤免疫特性及对胶质瘤患者预后的预测
Yan Hu,Zewei Tu,Kunjian Lei et al.
Yan Hu et al.
Background: Glioma is a malignant intracranial tumor and the most fatal cancer. The role of ferroptosis in the clinical progression of gliomas is unclear. ...