Down-regulating GRP78 reverses pirarubicin resistance of triple negative breast cancer by miR-495-3p mimics and involves the p-AKT/mTOR pathway [0.03%]
miR-495-3p模拟物通过下调GRP78逆转 pirarubicin 对三阴性乳腺癌耐药并涉及活化型 AKT/mTOR 信号通路
Mian Liu,Jiu Yang,Wuwu Lv et al.
Mian Liu et al.
Due to the lack of known therapeutic targets for triple-negative breast cancer (TNBC), chemotherapy is the only available pharmacological treatment. Pirarubicin (tetrahydropyranyl Adriamycin, THP) is the most commonly used anthracycline che...
Hsa_circ_0076931 suppresses malignant biological properties, down-regulates miR-6760-3p through direct binding, and up-regulates CCBE1 in glioma [0.03%]
Hsa_circ_0076931通过直接结合抑制miR-6760-3p在胶质瘤中起抑癌作用并上调CCBE1基因的表达
Yanbin Ke,Shixing Su,Chuanzhi Duan et al.
Yanbin Ke et al.
The function of circular RNAs (circRNAs) in gliomas is as yet unknown. The present study explored role of hsa_circ_0076931 in glioma. circRNA expression profiles were identified via RNA-seq followed by qRT-PCR validation in three pairs of g...
Prognostic value of miR-21 for prostate cancer: a systematic review and meta-analysis [0.03%]
miR-21在预测前列腺癌临床结局中的作用：系统评价和 Meta 分析
M Y Cynthia Stafford,Colin E Willoughby,Colum P Walsh et al.
M Y Cynthia Stafford et al.
Elevated levels of miR-21 expression are associated with many cancers, suggesting it may be a promising clinical biomarker. In prostate cancer (PCa), however, there is still no consensus about the usefulness of miR-21 as an indicator of dis...
Meta-Analysis
Bioscience reports. 2022 Jan 28;42(1):BSR20211972. DOI:10.1042/BSR20211972 2022
Retraction: Paracrine interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration [0.03%]
撤回：旁分泌白细胞介素-8通过Akt途径影响间充质干细胞并促进人脐静脉内皮细胞增殖和迁移
Retraction of Publication
Bioscience reports. 2021 Dec 22;41(12):BSR-2021-0198_RET. DOI:10.1042/BSR-2021-0198_RET 2021
Abnormal transaminase and lipid profiles in coexisting diseases in patients with fatty liver: a population study in Sichuan [0.03%]
四川脂肪肝合并疾病人群的转氨酶及血脂特征分析
Wei Jiang,Chang-Hai Liu,Dongbo Wu et al.
Wei Jiang et al.
Among chronic liver diseases, fatty liver has the highest incidence worldwide. Coexistence of fatty liver and other chronic diseases, such as diabetes, hepatitis B virus (HBV) and Helicobacter pylori (Hp) infection, is common in clinical pr...
Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers [0.03%]
整合分析发现亚甲基四氢叶酸脱氢酶1样作为五种不同人类癌症的独立共有的诊断和预后生物标志物
Nuzhat Sial,Jalil Ur Rehman,Saba Saeed et al.
Nuzhat Sial et al.
Background: Defects in methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) expression have earlier been examined in only a few human cancers. Objecti...
Circular RNAs in stem cells: from basic research to clinical implications [0.03%]
循环RNA在干细胞中的作用：从基础研究到临床意义
Hui-Juan Lu,Juan Li,Guodong Yang et al.
Hui-Juan Lu et al.
Circular RNAs (circRNAs) are a special class of endogenous RNAs with a wide variety of pathophysiological functions via diverse mechanisms, including transcription, microRNA (miRNA) sponge, protein sponge/decoy, and translation. Stem cells ...
CCNB2 is a novel prognostic factor and a potential therapeutic target in low-grade glioma [0.03%]
CCNB2是低级别胶质瘤中的一个新型预后因素和潜在治疗靶点
Dengfeng Wang,Hongjiao Sun,Xiaohui Li et al.
Dengfeng Wang et al.
Background: Cyclin B2 (CCNB2) is an important component of the cyclin pathway and plays a key role in the occurrence and development of cancer. However, the correlation between prognosis of low-grade glioma (LGG), CCNB2, ...
Regucalcin ameliorates doxorubicin-induced cytotoxicity in Cos-7 kidney cells and translocates from the nucleus to the mitochondria [0.03%]
雷洛昔芬通过将核转位至线粒体来改善柔红霉素诱导的非洲绿猴肾上皮细胞毒性
Noor A Mohammed,Israa J Hakeem,Nikolas Hodges et al.
Noor A Mohammed et al.
Doxorubicin (DOX) is a potent anticancer drug, which can have unwanted side-effects such as cardiac and kidney toxicity. A detailed investigation was undertaken of the acute cytotoxic mechanisms of DOX on kidney cells, using Cos-7 cells as ...
Neurotrophic factors combined with stem cells in the treatment of sciatic nerve injury in rats: a meta-analysis [0.03%]
神经生长因子联合干细胞治疗大鼠坐骨神经损伤的 Meta 分析研究
Kuang-Pin Liu,Wei Ma,Chun-Yan Li et al.
Kuang-Pin Liu et al.
Treatment of peripheral nerve regeneration with stem cells (SCs) alone has some limitations. For this reason, we evaluate the efficacy of neurotrophic factors combined with stem cell transplantation in the treatment of sciatic nerve injury ...
Meta-Analysis
Bioscience reports. 2022 Jan 28;42(1):BSR20211399. DOI:10.1042/BSR20211399 2022