Redox status of apolipoprotein E in cerebrospinal fluid: A mechanistically informative biomarker for central nervous system disorders [0.03%]
脑脊液中载脂蛋白E的氧化还原状态：中枢神经系统疾病的机制性生物标志物
Yui Uematsu,Wakana Iinuma,Riho Shimizu et al.
Yui Uematsu et al.
Apolipoprotein (apo) E is the major cholesterol carrier in the central nervous system (CNS); however, the clinical relevance of its cysteine-thiol redox status in cerebrospinal fluid (CSF) remains unclear. We investigated whether CSF apoE r...
Patients-derived AMOTL1 mutations lead to defective cell migration and tissue development [0.03%]
AMOTL1基因突变导致细胞迁移和组织发育缺陷
Jiaqian Luo,Ruxin Jin,Fang Geng et al.
Jiaqian Luo et al.
Angiomotin-like 1 (AMOTL1), by regulating cell-cell junctions, cell polarity, and cell migration, plays a critical role in organogenesis and development. Recently, multiple studies have identified two hotspot mutations in AMOTL1, Arg157 (R1...
Wanderley de Souza,Ana Paula Gadelha,Marlene Benchimol
Wanderley de Souza
The cytoskeleton is a key component of eukaryotic cells, including protists. It is composed of microtubules, microfilaments, and intermediate filaments. Here, we review the available information on the cytoskeleton of several relevant patho...
Rational Design Framework for Fluorescent Biosensors from Periplasmic Binding Proteins [0.03%]
基于周质结合蛋白的荧光生物传感器理性设计框架
Martín González-Andrade,Abril Gijsbers,Alejandro Sosa-Peinado et al.
Martín González-Andrade et al.
Periplasmic binding proteins (PBPs) are attractive scaffolds for fluorescent biosensors because they undergo large ligand-induced conformational changes and exhibit high specificity. Despite their potential, generalizable design strategies ...
Jun Qian,Zaozhi Song,Zhuoli Wei et al.
Jun Qian et al.
Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma [0.03%]
多聚r(C)结合蛋白(PCBP)1的表达受泛素E3连接酶UBE4A在甲状腺癌中的调控
Ming-Peng Zhang,Zaozhi Song,Wei-San Zhang et al.
Ming-Peng Zhang et al.
Tubulogenesis of bovine uterine glands by epidermal growth factor and collagen Ⅰ in 3D culture systems [0.03%]
表皮生长因子和Ⅰ型胶原蛋白诱导牛子宫内膜上皮细胞三维培养中子宫腺管形成的作用
Yosuke Sugino,Rei Ichikawa,Shuichi Matsuyama et al.
Yosuke Sugino et al.
Uterine glands are endometrial exocrine epithelia that support early embryo development. Their secretions are particularly essential for conceptus elongation in cattle. Uterine glands develop from the luminal epithelium and elongate into th...
G3BP1 is a SWI/SNF-bound regulator of transcription that modulates activation of STATs [0.03%]
G3BP1是SWI/SNF结合的转录调节因子，可调控STAT激活作用
Natalia Papadopoulos,Niki Sarri,Johan Lennartsson et al.
Natalia Papadopoulos et al.
RAS GTPase-activating protein-binding protein 1 (G3BP1) is a component of the RAS signaling pathway and a phosphorylation-dependent RNA/DNA endoribonuclease that links signal transduction and RNA metabolism. We identified G3BP1 as a nuclear...
Renal function dynamics in COVID-19: exploring biomarker interactions with D-dimer and C-reactive proteins [0.03%]
COVID-19的肾功能动态变化及与D-二聚体和C反应蛋白相互作用的生物标志物研究
Ishita Saha,Anirban Sinha,Anup Kumar Sadhu et al.
Ishita Saha et al.
COVID-19, caused by the SARS-CoV-2 virus, is mainly recognized for its respiratory manifestations. However, growing evidence regarding the widespread expression of ACE2 and TMPRSS2 receptors on diverse extrapulmonary sites, particularly in ...
Retraction: HDAC regulates the diabetic vascular endothelial dysfunction by targeting MnSOD [0.03%]
撤稿：HDAC通过靶向MnSOD调节糖尿病血管内皮功能障碍
Zehao Liu,Qian Hou,Ke Hu et al.
Zehao Liu et al.