Expression of Concern: Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p [0.03%]
表达关注：Hsa_circ_0026134通过海绵吸附miR-127-5P促进TRIM25和IGF2BP3介导的肝癌细胞增殖和侵袭的表达
Wei Zhang,Liang Zhu,Guowei Yang et al.
Wei Zhang et al.
Integrative Role of Orexigenic Peptides in Neuroprotection and Neurodegenerative Disease Modulation [0.03%]
orexigenic肽在神经保护和神经退行性疾病调节中的整合作用
Zuzana Sopko,Andrea Pačesová,Blanka Železná et al.
Zuzana Sopko et al.
The neuroprotective properties of several anorexigenic peptides, including leptin and GLP-1, are well established across models of neurodegenerative diseases. However, less is known about the role of orexigenic neuropeptides-including neuro...
Association of vitamin B1/B6/B12 supplementation with sphingosine-1-phosphate signaling and its receptors in multiple sclerosis patients: relevance to LISPR1 and APOA1-AS [0.03%]
维生素B1/B6/B12补充与多发性硬化症患者中的鞘氨醇-1-磷酸信号及其受体的相关性：LISPR1和APOA1-AS的相关意义
Noha A Mehana,Heba R Ghaiad,Mohammed M Nooh et al.
Noha A Mehana et al.
MS is a lifelong autoimmune disorder striking the central nervous system (CNS). Despite the currently used disease-modifying therapies, patients are exposed to persistent neuropathy, pinpointing the need for supportive therapy. Neurotropic ...
Structural characterization of the human CC2D1A fragment associated with non-syndromic intellectual disability (NSID) [0.03%]
人类CC2D1A片段的结构表征与非综合症性智障相关联
Yi-Hung Yeh,Min-Guan Lin,Xing-Han Sun et al.
Yi-Hung Yeh et al.
CC2D1A is a multidomain scaffold protein implicated in transcriptional regulation and autosomal recessive non-syndromic intellectual disability (NSID), yet its molecular mechanism is still poorly understood due to a lack of structural infor...
Conserved rod-to-spherical shape transitions in Escherichia coli through primordial experimental adaptations [0.03%]
通过原核生物的实验适应产生的大肠杆菌保守的杆状到球形的形态转换
Hui Lu,Yueyue Zhang,Boying Xu et al.
Hui Lu et al.
Cell shape plays a fundamental role in bacterial physiology, yet the evolutionary stability of morphological adaptations remains poorly understood. Our previous work suggested that Escherichia coli can evolve a spherical form under primordi...
Yonika A Larasati,Alexey Koval,Vladimir L Katanaev
Yonika A Larasati
GNAO1-related neurodevelopmental disorders are caused by mutations in the GNAO1 gene encoding the major neuronal G protein, Gαo. GNAO1 encephalopathies manifest in a range of symptoms, including epilepsy, movement disorder, hypotonia, and ...
Aerobic Exercise Is Associated with Divergent Regulation of Macrophage Migration Inhibitory Factor and Enhanced Remyelination in Experimental Autoimmune Neuritis [0.03%]
有氧运动通过分化调节巨噬细胞迁移抑制因子促进自身免疫性神经炎的再髓鞘化
Yantong Liu,Xiaohan Shi,Ying Wang et al.
Yantong Liu et al.
This study investigated the association between aerobic exercise preconditioning and macrophage migration inhibitory factor (MIF) expression, as well as myelination in sciatic nerve in experimental autoimmune neuritis (EAN) rats. Female Lew...
Effects of Low-Dose Lithium Supplementation on Thermal Inactivation of SERCA in Cardiac Muscle of Male Mice [0.03%]
低剂量补锂对雄性小鼠心肌SERCA热失活的影响
Sophie I Hamstra,Mia S Geromella,Panagiota Klentrou et al.
Sophie I Hamstra et al.
The sarco(endo)plasmic reticulum calcium (Ca2+)-ATPase 2 (SERCA2) is a crucial regulator of cardiac muscle function that is sensitive to changes in the cellular environment, such as increased oxidative stress. This can be observed in heat s...
Engineering extracellular vesicles for targeted therapeutic delivery in the heart [0.03%]
工程化细胞外囊泡实现心脏靶向治疗递送
Iqra Anwar,Xinghua Wang,Saverio Parlongo et al.
Iqra Anwar et al.
Heart failure is a leading cause of morbidity and mortality, highlighting the need for improved therapeutic strategies. Critical to the success of therapies is efficient and targeted delivery systems. Extracellular vesicle-based delivery sy...
A systematic review and meta-analysis of shRNA-IL-6-engineered CAR-T cells for B-cell Acute Lymphoblastic Leukemia: a stepping stone towards risk-free immunotherapy [0.03%]
用于治疗B细胞急性淋巴细胞白血病的shRNA-IL-6工程化CAR-T细胞的系统评价和荟萃分析：迈向风险免费免疫治疗的第一步
Mohamed S Attia,Brett Dyer,Nigel McMillan et al.
Mohamed S Attia et al.
Clinical application of chimeric antigen receptor (CAR)-T cells, especially those targeting CD19, stands as a breakthrough in treating relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL). Yet, preventing immune-related ad...