Structural and functional coupling in cross-linking uracil-DNA glycosylase UDGX [0.03%]
交联型尿嘧啶-DNA糖基化酶UDGX的结构与功能耦合机制研究
Chuan Liang,Ye Yang,Ping Ning et al.
Chuan Liang et al.
Enzymes in uracil-DNA glycosylase (UDG) superfamily are involved in removal of deaminated nucleobases such as uracil, methylcytosine derivatives such as formylcytosine and carboxylcytosine, and other base damage in DNA repair. UDGX is the l...
Melanogrit potentiates melanogenesis by escalating cellular tyrosinase activity and MITF levels via pERK inhibition [0.03%]
melanogrit通过抑制pERK来增强黑色素生成的作用机制研究
Acharya Balkrishna,Savita Lochab,Sudeep Verma et al.
Acharya Balkrishna et al.
Vitiligo is characterized by the development of white patches on the skin either due to the loss of functional melanocytes or perturbations in the melanogenesis pathway. In the present study, we investigated the therapeutic potential of her...
The differentiation courses of the Tfh cells: a new perspective on autoimmune disease pathogenesis and treatment [0.03%]
Tfh细胞的分化过程：自身免疫性疾病发病机制和治疗的新视角
Qingya Yang,Fang Zhang,Hongyi Chen et al.
Qingya Yang et al.
The follicular helper T cells are derived from CD4+T cells, promoting the formation of germinal centers and assisting B cells to produce antibodies. This review describes the differentiation process of Tfh cells from the perspectives of the...
Alteration in cartilage matrix stiffness as an indicator and modulator of osteoarthritis [0.03%]
软骨基质刚度的改变是骨关节炎的指示器和调节因子
Jing Song,Xuemin Zeng,Chenzhi Li et al.
Jing Song et al.
Osteoarthritis (OA) is characterized by cartilage degeneration and destruction, leading to joint ankylosis and disability. The major challenge in diagnosing OA at early stage is not only lack of clinical symptoms but also the insufficient h...
Commentary on: Increased stiffness of omental arteries from late pregnant women at advanced maternal age [0.03%]
评论：高龄产妇晚期妊娠期间腹膜后动脉僵硬度增加
Anna E Stanhewicz,Kelsey S Schwartz,Ruda Lee
Anna E Stanhewicz
Worldwide, pregnancy at age 35 or older, termed 'advanced maternal age (AMA)', is increasing exponentially. As the incidence of pregnancy at AMA has increased, a growing body of evidence has suggested that AMA is also associated with increa...
Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome [0.03%]
德沙胞辛预防通过修改外周血单核细胞炎性转录组来预防急性高山病
Rahul Kumar,Neha Chanana,Kavita Sharma et al.
Rahul Kumar et al.
Acute high-altitude (HA) exposure can induce several pathologies. Dexamethasone (DEX) can be taken prophylactically to prevent HA disease, but the mechanism by which it acts in this setting is unclear. We studied the transcriptome of periph...
Clinical Trial
Bioscience reports. 2023 Nov 30;43(11):BSR20231561. DOI:10.1042/BSR20231561 2023
Inhibition of smooth muscle cell death by Angiotensin 1-7 protects against abdominal aortic aneurysm [0.03%]
血管紧张素1-7通过抑制平滑肌细胞凋亡保护腹主动脉瘤
Anshul S Jadli,Karina P Gomes,Noura N Ballasy et al.
Anshul S Jadli et al.
Abdominal aortic aneurysm (AAA) represents a debilitating vascular disease characterized by aortic dilatation and wall rupture if it remains untreated. We aimed to determine the effects of Ang 1-7 in a murine model of AAA and to investigate...
MIR938 rs2505901 T>C polymorphism is associated with increased neuroblastoma risk in Chinese children [0.03%]
miR-938 rs2505901多态性与中国儿童神经母细胞瘤易感性的相关性研究
Susu Jiang,Xiuhong Sun,Xinxin Zhang et al.
Susu Jiang et al.
Neuroblastoma (NB) is a kind of childhood cancer that is a prevailing and deadly solid neoplasm among pediatric malignancies. The transcriptional output of MIR938 is capable of participating in the posttranscriptional modulation of gene exp...
Therapeutic activity of green synthesized selenium nanoparticles from turmeric against cisplatin-induced oxido-inflammatory stress and cell death in mice kidney [0.03%]
利用姜黄绿色合成的硒纳米颗粒对抗顺铂诱导的小鼠肾脏氧化炎症应激和细胞死亡的治疗活性
Barakat M ALRashdi,Roaya A Mohamed,Amal H Mohamed et al.
Barakat M ALRashdi et al.
Cisplatin (CDDP) is a commonly prescribed chemotherapeutic agent; however, its associated nephrotoxicity limits its clinical efficacy and sometimes requires discontinuation of its use. The existing study was designed to explore the reno-the...