Biological and mutational analyses of CXCR4-antagonist interactions and design of new antagonistic analogs [0.03%]
CXCR4-拮抗剂相互作用的生物和突变分析以及新拮抗类似物的设计
Qian Meng,Ruohan Zhu,Yujia Mao et al.
Qian Meng et al.
The chemokine receptor CXCR4 has become an attractive therapeutic target for HIV-1 infection, hematopoietic stem cell mobilization, and cancer metastasis. A wide variety of synthetic antagonists of CXCR4 have been developed and studied for ...
Metabolic hormones are integral regulators of female reproductive health and function [0.03%]
代谢激素是女性生殖健康和功能的整合调节因子
Faria Athar,Muskan Karmani,Nicole M Templeman
Faria Athar
The female reproductive system is strongly influenced by nutrition and energy balance. It is well known that food restriction or energy depletion can induce suppression of reproductive processes, while overnutrition is associated with repro...
Biological ammonium transporters from the Amt/Mep/Rh superfamily: mechanism, energetics, and technical limitations [0.03%]
来自Amt / Mep / Rh超家族的生物性铵转运体：机制，能量学和技术创新限制
Gordon Williamson,Adriana Bizior,Thomas Harris et al.
Gordon Williamson et al.
The exchange of ammonium across cellular membranes is a fundamental process in all domains of life and is facilitated by the ubiquitous Amt/Mep/Rh transporter superfamily. Remarkably, despite a high structural conservation in all domains of...
Wenjuan Xia,Ling Guo,Huapeng Su et al.
Wenjuan Xia et al.
N6-methyladenosine (m6A) is a highly prevalent modification found in mammal mRNA molecules that plays a crucial role in the regulation of cellular function. m6A RNA immunoprecipitation sequencing (MeRIP-seq) has been frequently used in tran...
The presence of a G-quadruplex prone sequence upstream of a minimal promoter increases transcriptional activity in the yeast Saccharomyces cerevisiae [0.03%]
一G四链体倾向序列的上游存在可增加酵母中的转录活性Saccharomyces cerevisiae минимальный промoter
Libuše Kratochvilová,Matúš Vojsovič,Natália Valková et al.
Libuše Kratochvilová et al.
Non-canonical secondary structures in DNA are increasingly being revealed as critical players in DNA metabolism, including modulating the accessibility and activity of promoters. These structures comprise the so-called G-quadruplexes (G4s) ...
Uncovering the essential roles of glutamate carboxypeptidase 2 orthologs in Caenorhabditis elegans [0.03%]
揭秘秀丽线虫谷氨酸氨基肽酶2同源物的至关重要作用
Lucie Panska,Stepanka Nedvedova,Vojtech Vacek et al.
Lucie Panska et al.
Human glutamate carboxypeptidase 2 (GCP2) from the M28B metalloprotease group is an important target for therapy in neurological disorders and an established tumor marker. However, its physiological functions remain unclear. To better under...
Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model [0.03%]
基于序列分析和AlphaFold2预测模型的人G6PC2功能关键结构基序的鉴定
Emily M Hawes,Derek P Claxton,James K Oeser et al.
Emily M Hawes et al.
G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit, primarily expressed in pancreatic islet β cells, which modulates the sensitivity of insulin secretion to glucose and thereby regulates fasting blood glucose (FBG). Mutationa...
Seyed Mostafa Noorbakhsh Varnosfaderani,Farnoosh Ebrahimzadeh,Mahsa Akbari Oryani et al.
Seyed Mostafa Noorbakhsh Varnosfaderani et al.
β-Glucans are valuable functional polysaccharides distributed in nature, especially in the cell walls of fungi, yeasts, bacteria, and cereals. The unique features of β-glucans, such as water solubility, viscosity, molecular weight, and so...
Study on the production of Sophorolipid by Starmerella bombicola yeast using fried waste oil fermentation [0.03%]
星形假丝酵母利用炸油废弃物发酵生产 sophorolipid 的研究
Haifeng Wang,Ruifang Gao,Xin Song et al.
Haifeng Wang et al.
Sophorolipids (SLs) are surface active compounds that have excellent surface-lowering properties. SLs were produced by Starmerella bombicola (CGMCC1576) yeast with sunflower seed oil, fried waste oil, cooked tung oil and raw tung oil used a...