GPR15LG regulates psoriasis-like inflammation by down-regulating inflammatory factors on keratinocytes [0.03%]
GPR15LG通过下调角质形成细胞的炎性因子调控类似银屑病的炎症反应
Caifeng Chen,Renhui Cai,Jun Zhou et al.
Caifeng Chen et al.
Psoriasis is a common chronic inflammatory skin disease characterized by aberrant proliferation of keratinocytes and infiltration of immune cells. We previously found that GPR15LG protein is highly expressed in psoriasis lesional skin and i...
Enhancing the potential of rapeseed cake as protein-source food by γ-irradiation [0.03%]
通过γ辐照提高菜籽粕作为蛋白质来源食物的潜力
Chuan Xiong,Xin Zou,Chia-Wei Phan et al.
Chuan Xiong et al.
Rapeseed cake serves as a by-product in the oil extraction industry, characterized by its elevated protein content. However, the presence of antinutritional factors limits the utilization of rapeseed cake as a viable protein source. In this...
New insights into GATOR2-dependent interactions and its conformational changes in amino acid sensing [0.03%]
GATOR2依赖性相互作用以及其在氨基酸感应中的构象变化的新见解
Can Yang,Xuan Sun,Geng Wu
Can Yang
Eukaryotic cells coordinate growth under different environmental conditions via mechanistic target of rapamycin complex 1 (mTORC1). In the amino-acid-sensing signalling pathway, the GATOR2 complex, containing five evolutionarily conserved s...
Jasmine Elanie Khairat,Muhammad Nur Adam Hatta,Nurshariza Abdullah et al.
Jasmine Elanie Khairat et al.
Septin proteins are a subfamily of closely related GTP-binding proteins conserved in all species except for higher plants and perform essential biological processes. Septins self-assemble into heptameric or octameric complexes and form high...
METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN [0.03%]
METTL3通过上调circCTTN的m6A修饰来促进人脐带间充质干细胞的成骨分化
Shujiang Chen,Xiaoqiong Duan,Yanjin He et al.
Shujiang Chen et al.
Background: Human umbilical cord mesenchymal stem cells (hUCMSCs) are promising seed cells in bone tissue engineering. circRNA and N6-methyladenosine (m6A) RNA methylation play important roles in osteogenic differentiatio...
Exploring the potential of VGLL3 methylation as a prognostic indicator for intracranial aneurysm with gender-specific considerations [0.03%]
VGLL3甲基化作为颅内动脉瘤预后指标的潜力探索及性别差异分析
Yuchun Liu,Siqi Chen,Enhao Zhang et al.
Yuchun Liu et al.
DNA methylation is widely recognized to play a role in intracranial aneurysm (IA) pathogenesis. We investigated the levels of methylation of vestigial-like 3 (VGLL3) in IA and explored its potential as a prognostic indicator. A total of 48 ...
Wanda Waterworth,Atheer Balobaid,Chris West
Wanda Waterworth
Seeds are the mode of propagation for most plant species and form the basis of both agriculture and ecosystems. Desiccation tolerant seeds, representative of most crop species, can survive maturation drying to become metabolically quiescent...
TCR β chain repertoire characteristic between healthy human CD4+ and CD8+ T cells [0.03%]
健康人体CD4+和CD8+ T细胞的TCR β链库特征
Ge Li,Yaqiong Chen,Yinji Liu et al.
Ge Li et al.
T cell is vital in the adaptive immune system, which relays on T-cell receptor (TCR) to recognize and defend against infection and tumors. T cells are mainly divided into well-known CD4+ and CD8+ T cells, which can recognize short peptide a...