Holly R Brittain,Caroline M Gorvin
Holly R Brittain
The balance between energy intake and energy expenditure determines whether we gain weight, and appetite regulatory circuits in the brain have a critical role in this energy balance. G protein-coupled receptors (GPCRs), the largest family o...
Chelsea Xinyi Yow,Sharon Yeoh,Eoin Leen et al.
Chelsea Xinyi Yow et al.
Neuroblastoma is a common solid tumour in children and accounts for a disproportionate share of childhood cancer mortality. High-risk neuroblastoma is a major clinical challenge, with survival rates below 50% despite intensive therapy. Ampl...
Retraction: Shaoyao-Gancao Decoction alleviated hyperandrogenism in a letrozole-induced rat model of polycystic ovary syndrome by inhibition of NF-κB activation [0.03%]
撤回：小剂量甘草汤通过抑制NF-κB活化缓解来曲唑诱导的多囊卵巢综合征模型大鼠高雄激素症
Jun-Jin Liu,Rui-Gang Hou,Yun-Yun Shao et al.
Jun-Jin Liu et al.
Synaptic Vesicle Architecture Modulates α-Synuclein Conformation and Pathogenic Transitions in Parkinson's Disease [0.03%]
突触小泡结构调控帕金森病中α-突触核蛋白构象及病理转换
Priyatosh Ranjan
Priyatosh Ranjan
α-Synuclein (α-Syn) is a presynaptic protein that regulates synaptic vesicle organization, SNARE complex assembly, and neurotransmitter release through reversible interactions with curved lipid membranes. Increasing evidence indicates tha...
Affinity purification contaminants identified by cryo-EM and mass spectrometry [0.03%]
基于低温电子显微镜和质谱鉴定的亲和纯化污染物
Emma R Belcher,Steven W Hardwick,Taiana Maia de Oliveira et al.
Emma R Belcher et al.
Affinity chromatography is a powerful and therefore popular method for the purification of proteins for structural studies. The success of the technique relies on the specificity of the interaction between the target protein and the affinit...
Apolipoprotein variations across APOE genotypes in young and elderly patients with coronary heart disease [0.03%]
冠心病青年及老年患者中载脂蛋白在不同APOE基因型中的变异
Yuxuan Zhang,Siwei Li,Shijie Xu et al.
Yuxuan Zhang et al.
Both the Apolipoprotein E (ApoE) genotype and apolipoprotein profiling are closely associated with the risk of coronary heart disease (CHD). However, it remains unclear whether APOE genotypes modulate the distribution of apolipoproteins and...
Maternal serum from "high-stress" pregnancies demonstrates bioactivity capable of attenuating neurite growth through a TNFα-dependent pathway in SH-SY5Y cells [0.03%]
高压力妊娠的母体血清具有通过TNFα依赖性途径抑制SH-SY5Y细胞神经突生长的能力
Clara Deady,Lars Wilmes,Fergus P McCarthy et al.
Clara Deady et al.
Prenatal stress is associated with deleterious neurodevelopmental consequences in affected offspring. Prenatal stress via exposure to high physiological levels of inflammation in utero may induce an inflammatory state in the fetal brain. Ho...
Retraction: Golgi integral membrane protein 4 manipulates cellular proliferation, apoptosis and cell cycle in human head and neck cancer [0.03%]
撤回：高尔基体膜蛋白4调控人类头颈部癌症细胞增殖、凋亡和细胞周期
Xiaobo Cui,Yunfei Bai,Dongxue Gao et al.
Xiaobo Cui et al.
Retraction: Silencing microRNA-27a inhibits proliferation and invasion of human osteosarcoma cells through the SFRP1-dependent Wnt/β-catenin signaling pathway [0.03%]
撤回：沉默microRNA-27a通过SFRP1依赖的Wnt/ β-catenin信号通路抑制人成骨肉瘤细胞的增殖和侵袭
Yuanyuan Shi,Junfeng Li,Yu Mu et al.
Yuanyuan Shi et al.
Clay P Renshaw,Keely M Rodriguez,Yftah Tal-Gan
Clay P Renshaw
Quorum sensing (QS) is a density-dependent communication process that enables bacteria to coordinate group behaviors, including competence, biofilm formation, bacteriocin production, and virulence. Early observations of genetic transformati...