Improvement of autochthonous Saccharomyces cerevisiae by rapid laboratory evolution technique of genome shuffling [0.03%]
利用基因组打乱技术快速进化改善自有的酿酒酵母菌株
Ravichandra Hospet,Devarajan Thangadurai,Jeyabalan Sangeetha et al.
Ravichandra Hospet et al.
The process of selecting indigenous Saccharomyces cerevisiae strains as a starter culture for specific fermentation has several requisites, including the assessment of distinct parameters based on desirable and traditional oenological crite...
Unlocking the potential: m6A-RNA methylation in severe epidermolysis bullosa simplex [0.03%]
解锁潜力：严重单纯性大疱性表皮松解症中的m6A RNA甲基化作用
Dario Leonardo Balacco,Benjamin J Hewitt,Ajoy Bardhan et al.
Dario Leonardo Balacco et al.
Epidermolysis bullosa simplex (EBS) is a rare genetic disorder, resulting from mutations in keratin 5 and keratin 14 (KRT14), and is characterised by skin fragility, herpetiform blistering, and the development of confluent palmoplantar kera...
Crystal structures and low-affinity complex formation of halogenase CtcP and FAD reductase CtcQ from the chlortetracycline biosynthetic pathway [0.03%]
氯四环素生物合成途径中的卤化酶CtcP和辅酶Q(FAD)还原酶CtcQ的晶体结构及低亲和力复合物形成机制研究
Caixia Hou,Sylvie Garneau-Tsodikova,Oleg Tsodikov
Caixia Hou
Enzymatic halogenation in natural products has been intensely investigated due to its potential utility as a tool to improve pharmacological and pharmaceutical properties of drug leads. Chlortetracycline (CTC), the first tetracycline (TC) a...
Development and validation of direct assay for cholesterol content of erythrocytes [0.03%]
直接测定红细胞胆固醇含量的方法及其验证
Azusa Yamazaki,Yuna Hakii,Akira Yoshimoto et al.
Azusa Yamazaki et al.
Erythrocytes contain a significant amount of membrane cholesterol, which is continuously exchanged with lipoproteins. Recent studies suggest that erythrocyte cholesterol content correlates positively with atherosclerotic cardiovascular dise...
The PAD4 inhibitor GSK484 diminishes neutrophil extracellular trap in the colon mucosa but fails to improve inflammatory biomarkers in experimental colitis [0.03%]
PAD4抑制剂GSK484可减少实验性结肠炎结肠黏膜中嗜中性粒细胞胞外陷阱的形成，但不能改善炎症标志物
Kangzhe Xie,Jordan Hunter,Aaron Lee et al.
Kangzhe Xie et al.
Inflammatory bowel disease (IBD) is a gastrointestinal disorder characterised by elevated colonic neutrophil extracellular traps (NETs), which are associated with disease severity. Formation of NETs is primarily driven by peptidyl arginine ...
Single-cell RNAseq of Angiotensin II-induced abdominal aortic tissue identifies aneurysm-associated cell clusters in C57BL/6J mice [0.03%]
血管紧张素II诱导的C57BL/6J小鼠腹主动脉组织的单细胞RNA测序鉴定出与动脉瘤相关的细胞簇
Huimin Li,Xueyu Hao,Peng Zhang et al.
Huimin Li et al.
Abdominal aortic aneurysms (AAAs) are life-threatening due to the rupture of aorta. Different vascular cell types are known to be involved in AAA development. However, whether any specific cell cluster plays a critical role during AAA forma...