Paratope mapping of tilvestamab, an anti-AXL function-blocking antibody, using high-throughput bacterial expression of secreted scFv-ompY fusion proteins [0.03%]
利用分泌型scFv-ompY融合蛋白的高通量细菌表达绘制抗AXL功能阻断抗体tilvestamab的结合位点图谱
Eleni Christakou,Petri Kursula,David Micklem
Eleni Christakou
Targeting AXL with a highly selective antibody presents a promising approach for inhibiting AXL and potentially improving cancer treatment. An essential step in antibody optimisation is the mapping of paratope residues to epitope residues. ...
High expression of Fgr in the left ventricle attenuates myocardial injury in the infarcted region via regulating the phosphorylation level of PI3K/Akt [0.03%]
Fgr在左心室的高表达通过调节PI3K/Akt磷酸化水平减轻梗死区心肌损伤
Dongpu Shao,Zhiguo Zhang,Honglei Ji et al.
Dongpu Shao et al.
FGR proto-oncogene (Fgr), a member of the Src family kinases, has garnered attention for its potential involvement in apoptotic signaling, yet its role in cardiovascular diseases, particularly acute myocardial infarction (AMI), remains unex...
Navid Bakshi,Madhuri Kanavalli,Karolina Z Nowak et al.
Navid Bakshi et al.
Ever since its discovery more than 70 years ago, the enzyme polynucleotide phosphorylase (PNPase) has been the subject of intensive research that has highlighted its key functional roles. The enzyme was first described in 1955 for its abili...
Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications [0.03%]
白藜芦醇苷治疗糖尿病及其慢性并发症的潜力作用研究进展
Farjana Yasmin,Kim San Tang
Farjana Yasmin
Diabetes mellitus is a complex metabolic disorder associated with severe complications affecting various organs, including the kidneys, nerves, heart, and blood vessels. Managing these complications remains a significant clinical challenge,...
Evaluating plasma adipokines and their cognate receptors, as biomarkers for non-invasive diagnosis of endometrial cancer [0.03%]
评估血浆脂联素及其受体作为非侵入性诊断子宫内膜癌的生物标志物
Rebecca Karkia PhD,Eshwa Zahra,Chaeyeoun Min et al.
Rebecca Karkia PhD et al.
Endometrial cancer (EC) is the most common gynaecological malignancy in developed countries. Early detection remains challenging, with no established plasma-based biomarkers for clinical use. This study aimed to evaluate plasma adipokines a...
Kinetic and Homology Model Analysis of Diaminopimelate Decarboxylase from Cyanothece sp. ATCC 51142: Unveiling A Key Enzyme in Lysine Biosynthesis [0.03%]
来伯氏热球菌的二氨基庚二酸脱羧酶的动力学及同源模建分析：揭示赖氨酸生物合成的关键酶
Zhi-Min Li,Suhang Chen,Weikang Luo et al.
Zhi-Min Li et al.
Diaminopimelate decarboxylase (DAPDC), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, catalyzes the decarboxylation of diaminopimelate (DAP) to yield L-lysine, a key step in lysine biosynthesis. This study presents a preliminary character...
Demixing of four simultaneously co-expressed phase-separating proteins in the endoplasmic reticulum lumen [0.03%]
内质网腔中四种同时共表达的相分离蛋白的解离
Haruki Hasegawa
Haruki Hasegawa
Intracellular protein crystallization represents an intriguing form of biomolecular assembly. While the list of intracellularly crystallizing proteins is growing and their physiological roles are being elucidated, the underlying requirement...
Structural insights into substrate binding, residue contributions, and catalytic mechanism of phosphopantetheine adenylyltransferase from Helicobacter pylori [0.03%]
幽门螺旋杆菌磷泛酰亚胺腺嘌呤二核苷酸转移酶的底物结合、关键氨基酸及其催化机制的结构研究
I-Ting Ko,Yi-Ting Yuan,Cheng-Ju Hsieh et al.
I-Ting Ko et al.
Phosphopantetheine adenylyltransferase (PPAT) (PPAT; EC 2.7.3.3) is a key enzyme in coenzyme A (CoA) biosynthesis. It catalyzes the reversible transfer of an adenylyl group from ATP to 4'-phosphopantetheine (Ppant), producing pyrophosphate ...
Kerim Yavuz,Nathan A Lack
Kerim Yavuz
The androgen receptor (AR) is the main driver of nearly all prostate cancer (PCa). It alters gene expression by binding to specific cis-regulatory elements on the DNA. Where the AR binds in the genome determines what genes are expressed. Ho...