Effects of orlistat combined with enzalutamide and castration through inhibition of fatty acid synthase in a PC3 tumor-bearing mouse model [0.03%]
奥利司他联合恩杂鲁胺和去势通过抑制脂肪合成酶在PC3肿瘤小鼠模型中的效果
Yeu-Sheng Tyan,Yen-Po Lee,Hui-Yen Chuang et al.
Yeu-Sheng Tyan et al.
Androgen deprivation therapy (ADT) is one of the typical treatments used for patients with prostate cancer (PCa). ADT, however, may fail when PCa develops castration-resistance. Fatty acid synthase (FASN), a critical enzyme involved in fatt...
Potential role for pyruvate kinase M2 in the regulation of murine cardiac glycolytic flux during in vivo chronic hypoxia [0.03%]
丙酮酸激酶M2在慢性缺氧条件下调节小鼠心肌糖酵解通量中的潜在作用
Michal K Handzlik,David J Tooth,Dumitru Constantin-Teodosiu et al.
Michal K Handzlik et al.
Carbohydrate metabolism in heart failure shares similarities to that following hypoxic exposure, and is thought to maintain energy homoeostasis in the face of reduced O2 availability. As part of these in vivo adaptations during sustained hy...
Glycogen synthase kinase 3β promotes osteosarcoma invasion and migration via regulating PTEN and phosphorylation of focal adhesion kinase [0.03%]
糖原合成酶激酶3β通过调节PTEN和焦黏附斑激酶的磷酸化促进骨肉瘤侵袭和迁移
Wei Mai,Lingyu Kong,Hongwei Yu et al.
Wei Mai et al.
Aim: Typical features of human osteosarcoma are highly invasive and migratory capacities. Our study aimed to investigate the roles of glycogen synthase kinase 3β (GSK3β) in human osteosarcoma metastasis. ...
Remifentanil preconditioning alleviates myocardial ischemia/reperfusion injury in rats via activating Jagged-1/Notch signaling pathway [0.03%]
瑞芬太尼预处理通过激活Jagged-1/Notch信号通路减轻大鼠心肌缺血再灌注损伤
Dejun Cao,Shaoxing Liu,Mengchang Yang et al.
Dejun Cao et al.
Ischemic heart diseases have emerged as great threats to human health. Nowadays, restoration of cardiac blood flow supply is widely regarded as a feasible treatment choice for ischemic heart diseases; however, this intervention would contra...
Reduction of TMAO level enhances the stability of carotid atherosclerotic plaque through promoting macrophage M2 polarization and efferocytosis [0.03%]
降低TMAO水平通过促进巨噬细胞M2极化和摄取死亡细胞来增强颈动脉斑块稳定性
Weihao Shi,Yijun Huang,Zhou Yang et al.
Weihao Shi et al.
It has been demonstrated that trimethylamine N-oxide (TMAO) serves as a driver of atherosclerosis, suggesting that reduction of TMAO level might be a potent method to prevent the progression of atherosclerosis. Herein, we explored the role ...
Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma [0.03%]
验证突触相关蛋白在低级别胶质瘤中的功能及预后价值
Han Lin,Yong Yang,Chongxian Hou et al.
Han Lin et al.
Synapse and synapse-associated proteins (SAPs) play critical roles in various neurodegeneration diseases and brain tumors. However, in lower-grade gliomas (LGG), SAPs have not been explored systematically. Herein, we are going to explore SA...
LncRNA UCA1 elevates the resistance of human leukemia cells to daunorubicin by the PI3K/AKT pathway via sponging miR-613 [0.03%]
长链非编码RNA UCA1通过海绵吸附miR-613活化PI3K / AKT途径提高人白血病细胞对柔红霉素的耐药性
Qiying Yao,Li Zhang,Yuchuan Wang et al.
Qiying Yao et al.
Acute leukemia is a hematological malignant tumor. Long non-coding RNA urothelial cancer-associated 1 (UCA1) is involved in the chemo-resistance of diverse cancers, but it is unclear whether UCA1 is associated with the sensitivity of acute ...
Integrated analysis of ceRNA network and tumor-infiltrating immune cells in esophageal cancer [0.03%]
整合分析食管癌中的ceRNA网络和肿瘤浸润性免疫细胞
Yuhua Chen,Hao Zhou,Zhendong Wang et al.
Yuhua Chen et al.
Background: Esophageal cancer (ESCA) is one of the most commonly diagnosed cancers in the world. Tumor immune microenvironment is closely related to tumor prognosis. The present study aimed at analyzing the competing endo...
Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas [0.03%]
LMNB1和DLGAP5在胶质瘤中的生物标志物作用及其机制研究
Ding Zhou,Mengmeng Wang,Yu Zhang et al.
Ding Zhou et al.
Glioma is the most common primary cancer in the central nervous system. Despite advances in surgery, radiotherapy and chemotherapy over the past decades, the prognosis of glioblastoma patients remains poor. We aim to identify robust gene si...
MicroRNA-543-3p down-regulates inflammation and inhibits periodontitis through KLF6 [0.03%]
microRNA-543-3p通过KLF6下调炎症并抑制牙周炎
Wei Li,Junwei Wang,Wenjing Hao et al.
Wei Li et al.
MicroRNA-543-3p (miR-543-3p) has been reported to be involved in many human disease's progression, but its role in inflammation is still unclear. After bacterial infection, innate immune cells are activated to trigger inflammation by recogn...