HIRA promotes osteogenic differentiation of BMSCs and ameliorates osteoporosis by mediating M2 polarization of macrophages through the YAP1/β-catenin pathway [0.03%]
介导巨噬细胞M2极化促进骨髓间充质干细胞成骨分化从而改善骨质疏松症：YAP1/β-catenin信号通路机制研究
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A cardiac fibrosis specific circRNA_006640 sponges miR-7648-3p and miR-185-3p to synergistically up-regulate CTGF [0.03%]
心肌纤维化特异性环状rna_circRNA_006640通过海绵作用吸附miR-7648-3p和miR-185-3p来协同上调CTGF表达
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Lijuan Yang et al.
Cardiac fibrosis is a critical pathological feature in nearly all forms of heart disease and contributes to heart failure. However, existing diagnostic and therapeutic approaches are insufficient for detecting fibrosis or targeting conventi...
LNA GapmeR silencing of KRAS G12V impairs growth and function in SW480 cells [0.03%]
LNA GapmeR沉默KRAS G12V抑制SW480细胞的生长和功能
Joudi Feras Khudeir,Abdelaziz Tlili
Joudi Feras Khudeir
Activating mutations in the KRAS oncogene, particularly the G12V substitution, are key drivers of tumorigenesis and therapeutic resistance across multiple cancer types. However, direct pharmacological inhibition of mutant KRAS has remained ...
The inflammatory-autophagy-NETs axis in renal fibrosis: mechanistic crosstalk and pathological feed-forward amplification loops [0.03%]
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Haixu Chen et al.
SENP1 regulates the malignant activities of osteosarcoma cells and antitumor immunity via the cGAS-STING signaling [0.03%]
SENP1通过cGAS-STING信号通路调节骨肉瘤细胞的恶性行为及肿瘤免疫监视功能
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Molecular and immune profiling of colorectal polyps using FTIR microspectroscopy [0.03%]
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Gustavo Jesus Vazquez-Zapien,Adriana Martinez-Cuazitl,Francisco Garibay-Gonzalez et al.
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Fenofibrate mitigates microglial activation by reprogramming lipid metabolism and inhibiting ferroptosis [0.03%]
泛氟纤维酸通过重新编程脂质代谢和抑制铁死亡来减轻小胶质细胞活化
Ahmet Taskesen,Ceyhan Hacioglu,Sibel Tuncer et al.
Ahmet Taskesen et al.
Microglial activation is a central mediator of neuroinflammatory and neurodegenerative processes. Growing evidence indicates that dysregulated lipid metabolism and ferroptosis drive microglial dysfunction, yet pharmacological interventions ...
USP53 regulates the AMPK pathway by deubiquitinating TJP2 to control the keloid-derived fibroblasts proliferation, invasion, and telomerase activity [0.03%]
USP53通过去泛素化TJP2调节AMPK通路以控制肥大细胞衍生的成纤维细胞增殖、侵袭和端粒酶活性
Jian Li,Yang Jiang,Baihui He et al.
Jian Li et al.
Nuclear factor I-C as a novel candidate regulator in postoperative atrial fibrillation: integrated omics and proof-of-concept validation [0.03%]
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Chaoyue Gao et al.