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Regional heterogeneity in vascular contractile dysfunction in diabetic mice [0.03%] 糖尿病小鼠血管收缩功能障碍的区域异质性研究
Nada A Sallam,Ismail Laher Nada A Sallam
Oxidative stress underlies many diabetic complications, including diabetic vasculopathy. It is unclear if oxidative stress has different effects in regionally distant arteries. We compared the contractile function of three arteries from dia...
Role of saturated fatty acid metabolism in posttranslational modifications of the Tau protein [0.03%] 饱和脂肪酸代谢在Tau蛋白翻译后修饰中的作用
Valeria Melissa García-Cruz,Roberto Coria,Clorinda Arias Valeria Melissa García-Cruz
The relationship between metabolic alterations induced by the consumption of a high-fat diet (HFD) and the risk of developing neurodegenerative diseases such as Alzheimer's disease (AD) has been extensively studied. In particular, the induc...
Q23.52024 Review Molecular and cellular biochemistry. 2025 Apr 10. DOI:10.1007/s11010-025-05275-2 2025
Human umbilical cord mesenchymal stem cell exosomes promote elastin production and acute skin wound healing via TGFβ1-Smad pathway [0.03%] 人源脐带间充质干细胞外泌体通过TGFβ1-Smad信号途径促进弹力蛋白生成及急性皮肤伤口愈合
Yi Zi,Jie Li,XinPing Qian et al. Yi Zi et al.
Skin wound healing is a complex physiological process influenced by multiple factors, including the patient's overall health status. Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-Exos) have demonstrated significa...
TOR1 AIP1 interacts with p53 to enhance cell cycle dysregulation in prostate cancer progression [0.03%] TOR1 AIP1通过与p53相互作用促进前列腺癌进展中的细胞周期失调
Zhaofeng Li,Xueyu Li,Han Yang et al. Zhaofeng Li et al.
The cell cycle mechanism is an integration point where information is sent through an upstream signaling network, making it a potential target for cancer diagnosis and treatment. The LAP1 protein, encoded by the Tor1aip1 gene, is required t...
Alkaloids as neuroprotectors: targeting signaling pathways in neurodegenerative diseases [0.03%] 神经保护类生物碱：靶向神经退行性疾病中的信号通路
Biswajit Kumar Utpal,Md Al Amin,Mehrukh Zehravi et al. Biswajit Kumar Utpal et al.
Neurodegeneration is the progressive loss of neurons that results in neurodegenerative diseases (NDs). Currently, there are few effective treatments for NDs, such as Alzheimer's disease, Parkinson's disease, Multiple sclerosis, and Huntingt...
Q23.52024 Review Molecular and cellular biochemistry. 2025 Apr 7. DOI:10.1007/s11010-025-05258-3 2025
Sodium butyrate attenuates liver fibrogenesis via promoting H4K8 crotonylation [0.03%] 丁酸钠通过促进H4K8克罗顿酸化来减轻肝纤维化
Ruiqi Tang,Hua Zha,Rongrong Liu et al. Ruiqi Tang et al.
Sodium butyrate (NaB), a histone deacetylase (HDAC) inhibitor derived from dietary sources, demonstrates its potential in improving liver fibrosis in mice. This study explored NaB's impact on liver fibrosis through histone crotonylation. In...
GDF15 attenuates Parkinson's disease progression via suppressing the activation of cGAS-STING pathway [0.03%] GDF15通过抑制cGAS-STING途径的激活来减缓帕金森病的进展
Jianli Wang,Ting Geng,Xiaomei Yao et al. Jianli Wang et al.
Growth differentiation Factor 15 (GDF15) plays an important role in the innate immune response. However, whether GDF15 could regulate Parkinson's disease (PD) remains unknown. In this study, we explored the function and underlying molecular...
Human dental follicle cell-derived conditioned media enhance periodontal regeneration by regulating the osteogenic differentiation and inflammation of periodontal ligament stem cells and macrophage polarization [0.03%] 人牙囊细胞条件培养基通过调节牙周膜干细胞成骨分化、炎症及巨噬细胞极化促进牙周组织再生
Yichen Gao,Xianyi He,Yuyao Deng et al. Yichen Gao et al.
Dental follicle cells (DFCs) derived from the neural crest are promising seed cells for periodontal tissue engineering. This study aimed to investigate whether conditioned media (CM) from human DFCs could regenerate impaired periodontal tis...
Myocardial infarction serum preconditioning bone marrow mesenchymal stem cell-derived exosomes enhance anti-fibrosis in rat myocardial infarction hearts [0.03%] 心梗血清预处理的骨髓间充质干细胞源性外泌体促进大鼠心肌梗死后抗纤维化作用
Yang Gan,Changyi Wang,Ruili Liao et al. Yang Gan et al.
Mesenchymal stem cells (MSCs) have been shown to attenuate myocardial fibrosis after myocardial infarction by secreting various bioactive molecules that positively affect the failing heart. We hypothesized that serum factors play an active ...
PUS7 promotes the progression of pancreatic cancer by interacting ANLN to activate MYC pathway [0.03%] PUS7通过与ANLN相互作用激活MYC通路促进胰腺癌进展
Yubo Jiang,Qian Cheng,Yingying Zhang et al. Yubo Jiang et al.
To investigate the role of pseudouridine synthase 7 (PUS7) in pancreatic cancer (PC) and explore its underlying molecular mechanisms. PUS7 role in the malignant biological function of PC cells was investigated by colony formation, EdU, flow...