Transplantation of Ru265-treated mitochondria enhances the therapeutic impact on skeletal muscle ischemia-reperfusion injury [0.03%]
Ru265处理的线粒体移植可增强对骨骼肌缺血再灌注损伤的治疗作用
Saima Barki,Fazal Wahid,Shafia Khan et al.
Saima Barki et al.
Mitochondrial transplantation (MT) is a promising therapeutic approach for the treatment of several pathologies, including ischemia-reperfusion injury (IRI). However, its efficacy remains limited by the high calcium concentration of the tra...
Polarized mitochondrial respiratory chain complexes in synaptic mitochondria induced by plasticity signals [0.03%]
由突触可塑性信号诱导的极化线粒体呼吸链复合物出现在突触线粒体中
Xi Wang,Gang Zhou,Yi Hu et al.
Xi Wang et al.
Mitochondria are well established as key supporters of synaptic plasticity, yet the nanoscale spatial distribution of specific mitochondrial membrane proteins during this process remains poorly understood. Using 3D MINFLUX nanoscopy, we inv...
Exploring the off-label use of liraglutide in the treatment of obesity: a review [0.03%]
利拉鲁肽治疗肥胖的超说明书用法探索——综述性文章
Carla Bruna Amorim Braga,João Paulo Viana Araújo Segundo,Carlos Alberto Alves Dias Filho
Carla Bruna Amorim Braga
Liraglutide, a glucagon-like peptide-1 (GLP-1) analog, has been used off-label for the treatment of obesity due to its considerable weight-reducing effects. This integrative review evaluated experimental studies in humans in order to explor...
Elevated placental inflammation as a mediator of adverse outcomes in gestational diabetes mellitus [0.03%]
妊娠糖尿病不良结局的介导因素：胎盘炎症增强的作用
Shweta Madiwale,Aditi Godhamgaonkar,Aishwarya Karkhanis et al.
Shweta Madiwale et al.
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication associated with adverse maternal and neonatal outcomes. This study aims to investigate the expression of key inflammatory markers - tumor necrosis factor-α (TNF-α),...
Squalene attenuates doxorubicin resistance in hepatocellular carcinoma by targeting SIRT6 to inhibit ERK1 deacetylation [0.03%]
角鲨烯通过靶向SIRT6抑制ERK1去乙酰化从而缓解肝癌细胞对阿霉素的耐药性
Geqiong Xiao,Furong Liu,Qiong Wang et al.
Geqiong Xiao et al.
Study on the pro-inflammatory mechanism mediated by the RANK-SPP1 axis in macrophage immunomodulation during atherosclerosis [0.03%]
关于动脉粥样硬化炎症过程中RANK-SPP1轴介导的巨噬细胞免疫调控机制的研究
Qiyu Sun,Yanbo Hu,Zeming Sun et al.
Qiyu Sun et al.
Atherosclerosis (AS) is a chronic inflammatory disease driven by macrophages. While the RANK/RANKL signaling axis and SPP1 (osteopontin) are individually known to contribute to vascular inflammation, whether they function within a coordinat...
Co-translational profiling in the cardiac endothelium in response to LPS-induced inflammation in female mice in vivo: a proof-of-concept approach [0.03%]
雌性小鼠LPS诱导的心肌内皮炎症条件下共翻译组的概念验证研究
Chad M Warren,Bhairavi Swaminathan,Paulina Langa et al.
Chad M Warren et al.
Producing functional proteins involves multiple steps during mRNA translation on the ribosomes. However, co-translational regulatory mechanisms remain poorly characterized in intact mammalian systems. As a proof-of-concept, we developed a m...
Association between obstructive sleep apnea, high-sensitivity c-reactive protein, and mitral annular calcification: a cross-sectional analysis of 200 adults undergoing routine medical evaluation [0.03%]
阻塞性睡眠呼吸暂停、超敏C反应蛋白与二尖瓣环钙化的相关性：来自200例行常规医学检查的成人患者的横断面分析
Jinyu Li,Aicheng Feng,Ye Li et al.
Jinyu Li et al.
USP7-stabilized CEBPB promotes HpSCC progression by upregulating IL6 to activate the JAK2/STAT3 signaling [0.03%]
USP7稳定CEBPD通过上调IL6激活JAK2/STAT3信号促进HpSCC进展
Honghui Li,Rong Fan,Yiping Qu et al.
Honghui Li et al.
Background: CCAAT/enhancer-binding protein B (CEBPB) has been reported as a transcription factor implicated in the occurrence and development of various human tumors. However, its role and mechanism in hypopharyngeal squa...
Cannabidiol potentiates olaparib-induced cytotoxicity through cell cycle arrest and DNA damage modulation in breast cancer cells [0.03%]
大麻二酚通过细胞周期停滞和DNA损伤调节增强奥拉帕尼诱导的乳腺癌细胞毒性
Cansın Deniz,Büşra Yüksel,Emre Cebeci et al.
Cansın Deniz et al.