TMED2 regulates macrophage polarization through MEK/ERK signaling pathway for osteosarcoma progression promotion [0.03%]
TMED2通过MEK/ERK信号通路调节巨噬细胞极化以促进骨肉瘤进展
Pingan Zou,Zhiwei Tao,Zhengxu Yang et al.
Pingan Zou et al.
Osteosarcoma (OS) is the most prevalent malignant tumor among adolescents, characterized by high recurrence rates and poor prognosis. Identifying novel prognostic biomarkers and therapeutic targets has become an urgent clinical need. We ana...
Semaglutide ameliorates neuroinflammation and cognitive impairment in APP/PS1 mice [0.03%]
塞meglutide可改善APP / PS1小鼠的神经炎症和认知障碍
Yuan Yuan,Jiawei Zhang,Ziyao Zhang et al.
Yuan Yuan et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown neuroprotective potential, but the mechanisms underlying these effects ...
Genetic regulation of insulin resistance surrogate index (TyG) and susceptibility to common diseases based on phenome-wide association study [0.03%]
基于表型组关联研究的胰岛素抵抗替代指标(TyG)的遗传调控及其对常见病易感性的影响
Jia-Xin Wu,Ling-Huan Bu,Pei He et al.
Jia-Xin Wu et al.
Insulin resistance (IR) is a crucial driver of numerous metabolic and non-metabolic diseases, yet the associations between the triglyceride-glucose (TyG) index-a marker for IR-and a broad spectrum of health conditions remain poorly understo...
TangShenKang decoction plays an anti-inflammatory and anti-fibrotic role in diabetic nephropathy by activating AT2R/ATIP1/SHP1 axis and antagonizing angiotensin II [0.03%]
唐肾康汤通过激活AT2R/ATIP1/SHP1轴并对抗血管紧张素II在糖尿病肾病中发挥抗炎和抗纤维化作用
Ran Wei,Jian Ma,Zeyu Yu et al.
Ran Wei et al.
Diabetic nephropathy (DN) is the most prevalent microvascular complication of diabetes, where a hyperglycemic environment can induce chronic damage to renal vessels and parenchyma, severely endangering patients' health. TangShenKang decocti...
Dose- and time-dependent cardioprotection of liproxstatin-1 via sequential modulation of ferroptosis pathways after myocardial ischemia-reperfusion [0.03%]
脂糖定-1通过顺序调节缺血再灌注后铁死亡通路从而以剂量和时间依赖性保护心脏作用
Ziwei Huang,Xixi Chen,Junyi Ren et al.
Ziwei Huang et al.
Myocardial ischemia-reperfusion (MI/R) injury significantly limits the clinical benefits of coronary reperfusion therapy. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has been implicated in myoca...
Innovative valsartan-loaded self-nanoemulsifying drug delivery system combat liver inflammation and oxidative stress in streptozotocin-induced diabetic rats [0.03%]
创新缬沙坦自纳米乳化药物递送系统对抗链佐星诱导的糖尿病大鼠肝炎和氧化应激
Hanan Elimam,Jihan Hussein,Mona El-Banna et al.
Hanan Elimam et al.
Diabetes-induced liver damage is a significant complication of hyperglycemia, which results in oxidative stress, inflammation, and fibrosis. Conventional treatment strategies remain limited, necessitating novel therapeutic approaches. This ...
Ubiquitin's code: UPS orchestrating DNA repair and genomic stability under genotoxic stress [0.03%]
泛素的密码：在致突变压力下通过泛素蛋白酶体系统(Ubiquitin-Proteasome System, UPS)调控DNA修复与基因组稳定性
Srija Roy,Gouranga Saha,Malini Basu et al.
Srija Roy et al.
The genetic blueprint of life faces ongoing threats from physical and chemical agents that can disrupt DNA and lead to genomic instability, which is one of the hallmarks of cancer. These agents include external factors like ionizing radiati...
Puerarin alleviates myocardial ischemia-reperfusion injury by enhancing FUNDC1-mediated mitophagy [0.03%]
葛根素通过增强FUNDC1介导的线粒体自噬缓解心肌缺血再灌注损伤
Na Feng,Anhua Zhang,Lingling Yao et al.
Na Feng et al.
Myocardial ischemia‑reperfusion injury (I/R) is a major contributor to adverse outcomes in ischemic heart disease. Mitochondrial dysfunction plays a central role in I/R, and modulating mitophagy has shown potential in attenuating such inju...
Disulfidptosis-related gene DSTN predicts prognosis and promotes malignant progression in head and neck squamous cell carcinoma [0.03%]
二硫化物异构酶DSTN在头颈部鳞状细胞癌中的预后和促恶性进展作用研究
Xingzhi Peng,Likang Chen,Jing Zhang et al.
Xingzhi Peng et al.
Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck tissues. Disulfidptosis is a novel form of programmed cell death caused by disulfide stress, which mainly manifests as cytoskeleton protei...
Inhibition of endothelial S1PR2 preserves blood-brain barrier integrity after traumatic brain injury through activating the PI3K-AKT signaling pathway [0.03%]
内皮细胞S1PR2抑制通过激活PI3K-AKT信号通路在创伤性脑损伤后保护血脑屏障完整性的研究
Hongbo Cheng,Qin Wang,Yijiao Men et al.
Hongbo Cheng et al.
Traumatic brain injury (TBI) is a major cause of blood-brain barrier (BBB) disruption and neurological dysfunction, wherein endothelial dysfunction plays a critical pathogenic role. As a member of the G protein-coupled receptor family, sphi...